Risk of metachronous colorectal cancer after colectomy for first colon cancer in Lynch syndrome: multicenter retrospective study in Japan
CONCLUSIONS: To reduce the incidence of mCRC, patients with genetically diagnosed LS and fCC, preferentially located in the left-sided colon, may need to undergo more extended colectomy than that usually performed in Japan. However, such extended colectomy should be counterbalanced with favorable overall survival and actual risk of mCRC development.PMID:37752370 | DOI:10.1007/s10147-023-02412-z (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - September 26, 2023 Category: Cancer & Oncology Authors: Kenichi Chikatani Hideyuki Ishida Yoshiko Mori Takeshi Nakajima Arisa Ueki Kiwamu Akagi Akinari Takao Masayoshi Yamada Fumitaka Taniguchi Koji Komori Kazuhito Sasaki Tomoya Sudo Yasuyuki Miyakura Akiko Chino Tatsuro Yamaguchi Kohji Tanakaya Naohiro Tomita Source Type: research
Risk of metachronous colorectal cancer after colectomy for first colon cancer in Lynch syndrome: multicenter retrospective study in Japan
ConclusionsTo reduce the incidence of mCRC, patients with genetically diagnosed LS and fCC, preferentially located in the left-sided colon, may need to undergo more extended colectomy than that usually performed in Japan. However, such extended colectomy should be counterbalanced with favorable overall survival and actual risk of mCRC development. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 26, 2023 Category: Cancer & Oncology Source Type: research
Features of colorectal adenomas among young patients with Lynch syndrome according to path_MMR: Results from the PRED-IdF registry
Lynch syndrome (LS) is the most frequent inherited colorectal cancer syndrome. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 25, 2023 Category: Gastroenterology Authors: Hadrien Alric, Elise Coffin, Celine Lekhal, Patrick R. Benusiglio, Marion Dhooge, Chrystelle Colas, Olivier Caron, Veronica Cusin, Aymeric Becq, Enrique Perez Cuadrado Robles, Romain Leenhardt, Geraldine Perkins, Bruno Buecher, J érôme Bellanger, Gabrie Tags: Oncology Source Type: research
Comparison of immediate germline sequencing and multi-step screening for Lynch syndrome detection in high-risk endometrial and colorectal cancer patients
CONCLUSION: Our study suggests that IGS may potentially offer a more effective approach compared to MSP in identifying LS among high-risk patients. This advantage is evident when patients have been pre-selected utilizing specific clinical criteria.PMID:37743058 | DOI:10.3802/jgo.2024.35.e5 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - September 24, 2023 Category: OBGYN Authors: An-Shine Chao Angel Chao Chyong-Huey Lai Chiao-Yun Lin Lan-Yan Yang Shih-Cheng Chang Ren-Chin Wu Source Type: research
