Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
Australian Society for Parasitology 2023: One Health, one globe
Trends Parasitol. 2023 Oct 12:S1471-4922(23)00237-4. doi: 10.1016/j.pt.2023.09.016. Online ahead of print.NO ABSTRACTPMID:37838512 | DOI:10.1016/j.pt.2023.09.016 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 14, 2023 Category: Parasitology Authors: Deborah C Holt Steven Kho Christian Doerig Suji Yoo O'Connor Madeleine Ray Maree Widdicombe Luke M Hall Angelica Fiona Tan Timothy K C Ho Alessia Hysa Kaitlin Pekin Keira Brown Source Type: research
Vaccines against tick-borne diseases: a big step forward?
Trends Parasitol. 2023 Oct 12:S1471-4922(23)00254-4. doi: 10.1016/j.pt.2023.10.001. Online ahead of print.ABSTRACTTicks and tick-borne diseases are on the rise due to socioecosystemic changes and climate modification and are affecting human and animal health. Few vaccines are available. Two recent articles from Matias et al. and Pine et al. used mRNA technology to explore tick and pathogen proteins as vaccine candidates.PMID:37838513 | DOI:10.1016/j.pt.2023.10.001 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 14, 2023 Category: Parasitology Authors: Nathalie Boulanger Stephen Wikel Source Type: research
Tick salivary glycans - a sugar-coated tick bite
Trends Parasitol. 2023 Oct 12:S1471-4922(23)00233-7. doi: 10.1016/j.pt.2023.09.012. Online ahead of print.ABSTRACTTicks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure successful feeding and pathogen transmission. These salivary proteins are often glycosylated, and glycosylation is potentially critical for the function of these proteins. Some salivary glycans are linked to the phenomenon of red meat allergy - an allergic response to red meat consumption in humans exposed to certain ...
Source: Trends in Parasitology - October 14, 2023 Category: Parasitology Authors: Shahid Karim Juan Manuel Leyva-Castillo Sukanya Narasimhan Source Type: research
Australian Society for Parasitology 2023: One Health, one globe
Trends Parasitol. 2023 Oct 12:S1471-4922(23)00237-4. doi: 10.1016/j.pt.2023.09.016. Online ahead of print.NO ABSTRACTPMID:37838512 | DOI:10.1016/j.pt.2023.09.016 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 14, 2023 Category: Parasitology Authors: Deborah C Holt Steven Kho Christian Doerig Suji Yoo O'Connor Madeleine Ray Maree Widdicombe Luke M Hall Angelica Fiona Tan Timothy K C Ho Alessia Hysa Kaitlin Pekin Keira Brown Source Type: research
Vaccines against tick-borne diseases: a big step forward?
Trends Parasitol. 2023 Oct 12:S1471-4922(23)00254-4. doi: 10.1016/j.pt.2023.10.001. Online ahead of print.ABSTRACTTicks and tick-borne diseases are on the rise due to socioecosystemic changes and climate modification and are affecting human and animal health. Few vaccines are available. Two recent articles from Matias et al. and Pine et al. used mRNA technology to explore tick and pathogen proteins as vaccine candidates.PMID:37838513 | DOI:10.1016/j.pt.2023.10.001 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 14, 2023 Category: Parasitology Authors: Nathalie Boulanger Stephen Wikel Source Type: research
Tick salivary glycans - a sugar-coated tick bite
Trends Parasitol. 2023 Oct 12:S1471-4922(23)00233-7. doi: 10.1016/j.pt.2023.09.012. Online ahead of print.ABSTRACTTicks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure successful feeding and pathogen transmission. These salivary proteins are often glycosylated, and glycosylation is potentially critical for the function of these proteins. Some salivary glycans are linked to the phenomenon of red meat allergy - an allergic response to red meat consumption in humans exposed to certain ...
Source: Trends in Parasitology - October 14, 2023 Category: Parasitology Authors: Shahid Karim Juan Manuel Leyva-Castillo Sukanya Narasimhan Source Type: research
