Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
It's not all about flagella - sticky invasion by pathogenic spirochetes
Trends Parasitol. 2024 Mar 23:S1471-4922(24)00071-0. doi: 10.1016/j.pt.2024.03.004. Online ahead of print.ABSTRACTPathogenic spirochetes cause a range of serious human diseases such as Lyme disease (LD), syphilis, leptospirosis, relapsing fever (RF), and periodontal disease. Motility is a critical virulence factor for spirochetes. From the mechanical perspective of the infection, it has been widely believed that flagella are the sole key players governing the migration and dissemination of these pathogens in the host. Here, we highlight the important contribution of spirochetal surface-exposed adhesive molecules and their ...
Source: Trends in Parasitology - March 24, 2024 Category: Parasitology Authors: Martin Strnad Nobuo Koizumi Shuichi Nakamura Marie Vancov á Ryan O M Rego Source Type: research
It's not all about flagella - sticky invasion by pathogenic spirochetes
Trends Parasitol. 2024 Mar 23:S1471-4922(24)00071-0. doi: 10.1016/j.pt.2024.03.004. Online ahead of print.ABSTRACTPathogenic spirochetes cause a range of serious human diseases such as Lyme disease (LD), syphilis, leptospirosis, relapsing fever (RF), and periodontal disease. Motility is a critical virulence factor for spirochetes. From the mechanical perspective of the infection, it has been widely believed that flagella are the sole key players governing the migration and dissemination of these pathogens in the host. Here, we highlight the important contribution of spirochetal surface-exposed adhesive molecules and their ...
Source: Trends in Parasitology - March 24, 2024 Category: Parasitology Authors: Martin Strnad Nobuo Koizumi Shuichi Nakamura Marie Vancov á Ryan O M Rego Source Type: research
Exploiting integrative metabolomics to study host-parasite interactions in Plasmodium infections
Trends Parasitol. 2024 Mar 19:S1471-4922(24)00032-1. doi: 10.1016/j.pt.2024.02.007. Online ahead of print.ABSTRACTDespite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine me...
Source: Trends in Parasitology - March 20, 2024 Category: Parasitology Authors: Maria Nikulkova Wael Abdrabou Jane M Carlton Youssef Idaghdour Source Type: research
Exploiting integrative metabolomics to study host-parasite interactions in Plasmodium infections
Trends Parasitol. 2024 Mar 19:S1471-4922(24)00032-1. doi: 10.1016/j.pt.2024.02.007. Online ahead of print.ABSTRACTDespite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine me...
Source: Trends in Parasitology - March 20, 2024 Category: Parasitology Authors: Maria Nikulkova Wael Abdrabou Jane M Carlton Youssef Idaghdour Source Type: research
Exploiting integrative metabolomics to study host-parasite interactions in Plasmodium infections
Trends Parasitol. 2024 Mar 19:S1471-4922(24)00032-1. doi: 10.1016/j.pt.2024.02.007. Online ahead of print.ABSTRACTDespite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine me...
Source: Trends in Parasitology - March 20, 2024 Category: Parasitology Authors: Maria Nikulkova Wael Abdrabou Jane M Carlton Youssef Idaghdour Source Type: research
Exploiting integrative metabolomics to study host-parasite interactions in Plasmodium infections
Trends Parasitol. 2024 Mar 19:S1471-4922(24)00032-1. doi: 10.1016/j.pt.2024.02.007. Online ahead of print.ABSTRACTDespite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine me...
Source: Trends in Parasitology - March 20, 2024 Category: Parasitology Authors: Maria Nikulkova Wael Abdrabou Jane M Carlton Youssef Idaghdour Source Type: research
From a bimodal to a multi-stage view on trypanosomes' differential RNA editing
Trends Parasitol. 2024 Mar 16:S1471-4922(24)00048-5. doi: 10.1016/j.pt.2024.02.009. Online ahead of print.ABSTRACTSignificant variations in the abundance of mitochondrial RNA processing proteins and their target RNAs across trypanosome life stages present an opportunity to explore the regulatory mechanisms that drive these changes. Utilizing omics approaches can uncover unconventional targets, aiding our understanding of the parasites' adaptation and enabling targeted interventions for differentiation.PMID:38494388 | DOI:10.1016/j.pt.2024.02.009 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 17, 2024 Category: Parasitology Authors: Homa Zamani Naghmeh Poorinmohammad Amin Azimi Reza Salavati Source Type: research
From a bimodal to a multi-stage view on trypanosomes' differential RNA editing
Trends Parasitol. 2024 Mar 16:S1471-4922(24)00048-5. doi: 10.1016/j.pt.2024.02.009. Online ahead of print.ABSTRACTSignificant variations in the abundance of mitochondrial RNA processing proteins and their target RNAs across trypanosome life stages present an opportunity to explore the regulatory mechanisms that drive these changes. Utilizing omics approaches can uncover unconventional targets, aiding our understanding of the parasites' adaptation and enabling targeted interventions for differentiation.PMID:38494388 | DOI:10.1016/j.pt.2024.02.009 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 17, 2024 Category: Parasitology Authors: Homa Zamani Naghmeh Poorinmohammad Amin Azimi Reza Salavati Source Type: research
From a bimodal to a multi-stage view on trypanosomes' differential RNA editing
Trends Parasitol. 2024 Mar 16:S1471-4922(24)00048-5. doi: 10.1016/j.pt.2024.02.009. Online ahead of print.ABSTRACTSignificant variations in the abundance of mitochondrial RNA processing proteins and their target RNAs across trypanosome life stages present an opportunity to explore the regulatory mechanisms that drive these changes. Utilizing omics approaches can uncover unconventional targets, aiding our understanding of the parasites' adaptation and enabling targeted interventions for differentiation.PMID:38494388 | DOI:10.1016/j.pt.2024.02.009 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 17, 2024 Category: Parasitology Authors: Homa Zamani Naghmeh Poorinmohammad Amin Azimi Reza Salavati Source Type: research
Unlocking the mystery of the feeder organelle and versatile energy metabolism in Cryptosporidium parvum
Trends Parasitol. 2024 Mar 13:S1471-4922(24)00056-4. doi: 10.1016/j.pt.2024.03.002. Online ahead of print.ABSTRACTXu and colleagues recently revealed the critical role of Cryptosporidium's feeder organelle in nutrient uptake, showcasing the parasite's ability to harness glucose and glucose-6-phosphate from host cells. This illuminates the sophisticated energy metabolism and survival strategies of the parasite, highlighting potential therapeutic targets.PMID:38485578 | DOI:10.1016/j.pt.2024.03.002 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 14, 2024 Category: Parasitology Authors: Dongqiang Wang Guan Zhu Source Type: research
Itaconate as a potential target for antimalarial therapy
Trends Parasitol. 2024 Mar 13:S1471-4922(24)00057-6. doi: 10.1016/j.pt.2024.03.003. Online ahead of print.ABSTRACTIn a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC) mobilization in response to Plasmodium infection. The authors showed that elevated levels of itaconate in MODCs results in reduced CD8 T cell activation and that the absence of itaconate is associated with enhanced parasite control.PMID:38485579 | DOI:10.1016/j.pt.2024.03.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 14, 2024 Category: Parasitology Authors: Jonathon P Bernardi Taylen J Nappi Noah S Butler Source Type: research
Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis
Trends Parasitol. 2024 Mar 13:S1471-4922(24)00055-2. doi: 10.1016/j.pt.2024.03.001. Online ahead of print.ABSTRACTDu, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.PMID:38485580 | DOI:10.1016/j.pt.2024.03.001 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 14, 2024 Category: Parasitology Authors: Maria Saeed Elizabeth H Aitken Stephen J Rogerson Source Type: research
Unlocking the mystery of the feeder organelle and versatile energy metabolism in Cryptosporidium parvum
Trends Parasitol. 2024 Mar 13:S1471-4922(24)00056-4. doi: 10.1016/j.pt.2024.03.002. Online ahead of print.ABSTRACTXu and colleagues recently revealed the critical role of Cryptosporidium's feeder organelle in nutrient uptake, showcasing the parasite's ability to harness glucose and glucose-6-phosphate from host cells. This illuminates the sophisticated energy metabolism and survival strategies of the parasite, highlighting potential therapeutic targets.PMID:38485578 | DOI:10.1016/j.pt.2024.03.002 (Source: Trends in Parasitology)
Source: Trends in Parasitology - March 14, 2024 Category: Parasitology Authors: Dongqiang Wang Guan Zhu Source Type: research
