Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00285-4. doi: 10.1016/j.pt.2023.11.005. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum parasites; it is characterized by the sequestration of infected red blood cells within the cerebral microvasculature. New findings, combined with a better understanding of the central nervous system (CNS) barriers, have provided greater insight into the players and events involved in CM, including site-specific T cell responses in the human brain. Here, we review the updated roles of innate and adaptive immune responses i...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Samuel C Wassmer Tania F de Koning-Ward Georges E R Grau Saparna Pai Source Type: research
Translating mosquito viromes into vector management strategies
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00282-9. doi: 10.1016/j.pt.2023.11.002. Online ahead of print.ABSTRACTMosquitoes are best known for transmitting human and animal viruses. However, they also harbour mosquito-specific viruses (MSVs) as part of their microbiota. These are a group of viruses whose diversity and prevalence overshadow their medically relevant counterparts. Although metagenomics sequencing has remarkably accelerated the discovery of these viruses, what we know about them is often limited to sequence information, leaving much of their fundamental biology to be explored. Understanding the biology and eco...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Cassandra Koh Maria-Carla Saleh Source Type: research
Phylogenetic framework to explore trait evolution in Trypanosomatidae
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00289-1. doi: 10.1016/j.pt.2023.11.009. Online ahead of print.ABSTRACTThe number of sequenced trypanosomatid genomes has reached a critical point so that they are now available for almost all genera and subgenera. Based on this, we inferred a phylogenomic tree and propose it as a framework to study trait evolution together with some examples of how to do it.PMID:38065790 | DOI:10.1016/j.pt.2023.11.009 (Source: Trends in Parasitology)
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Alexei Yu Kostygov Amanda T S Albanaz Anzhelika Butenko Evgeny S Gerasimov Julius Luke š Vyacheslav Yurchenko Source Type: research
Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00285-4. doi: 10.1016/j.pt.2023.11.005. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum parasites; it is characterized by the sequestration of infected red blood cells within the cerebral microvasculature. New findings, combined with a better understanding of the central nervous system (CNS) barriers, have provided greater insight into the players and events involved in CM, including site-specific T cell responses in the human brain. Here, we review the updated roles of innate and adaptive immune responses i...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Samuel C Wassmer Tania F de Koning-Ward Georges E R Grau Saparna Pai Source Type: research
Translating mosquito viromes into vector management strategies
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00282-9. doi: 10.1016/j.pt.2023.11.002. Online ahead of print.ABSTRACTMosquitoes are best known for transmitting human and animal viruses. However, they also harbour mosquito-specific viruses (MSVs) as part of their microbiota. These are a group of viruses whose diversity and prevalence overshadow their medically relevant counterparts. Although metagenomics sequencing has remarkably accelerated the discovery of these viruses, what we know about them is often limited to sequence information, leaving much of their fundamental biology to be explored. Understanding the biology and eco...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Cassandra Koh Maria-Carla Saleh Source Type: research
Phylogenetic framework to explore trait evolution in Trypanosomatidae
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00289-1. doi: 10.1016/j.pt.2023.11.009. Online ahead of print.ABSTRACTThe number of sequenced trypanosomatid genomes has reached a critical point so that they are now available for almost all genera and subgenera. Based on this, we inferred a phylogenomic tree and propose it as a framework to study trait evolution together with some examples of how to do it.PMID:38065790 | DOI:10.1016/j.pt.2023.11.009 (Source: Trends in Parasitology)
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Alexei Yu Kostygov Amanda T S Albanaz Anzhelika Butenko Evgeny S Gerasimov Julius Luke š Vyacheslav Yurchenko Source Type: research
Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00285-4. doi: 10.1016/j.pt.2023.11.005. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum parasites; it is characterized by the sequestration of infected red blood cells within the cerebral microvasculature. New findings, combined with a better understanding of the central nervous system (CNS) barriers, have provided greater insight into the players and events involved in CM, including site-specific T cell responses in the human brain. Here, we review the updated roles of innate and adaptive immune responses i...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Samuel C Wassmer Tania F de Koning-Ward Georges E R Grau Saparna Pai Source Type: research
Translating mosquito viromes into vector management strategies
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00282-9. doi: 10.1016/j.pt.2023.11.002. Online ahead of print.ABSTRACTMosquitoes are best known for transmitting human and animal viruses. However, they also harbour mosquito-specific viruses (MSVs) as part of their microbiota. These are a group of viruses whose diversity and prevalence overshadow their medically relevant counterparts. Although metagenomics sequencing has remarkably accelerated the discovery of these viruses, what we know about them is often limited to sequence information, leaving much of their fundamental biology to be explored. Understanding the biology and eco...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Cassandra Koh Maria-Carla Saleh Source Type: research
Phylogenetic framework to explore trait evolution in Trypanosomatidae
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00289-1. doi: 10.1016/j.pt.2023.11.009. Online ahead of print.ABSTRACTThe number of sequenced trypanosomatid genomes has reached a critical point so that they are now available for almost all genera and subgenera. Based on this, we inferred a phylogenomic tree and propose it as a framework to study trait evolution together with some examples of how to do it.PMID:38065790 | DOI:10.1016/j.pt.2023.11.009 (Source: Trends in Parasitology)
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Alexei Yu Kostygov Amanda T S Albanaz Anzhelika Butenko Evgeny S Gerasimov Julius Luke š Vyacheslav Yurchenko Source Type: research
Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis
Trends Parasitol. 2023 Dec 7:S1471-4922(23)00285-4. doi: 10.1016/j.pt.2023.11.005. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum parasites; it is characterized by the sequestration of infected red blood cells within the cerebral microvasculature. New findings, combined with a better understanding of the central nervous system (CNS) barriers, have provided greater insight into the players and events involved in CM, including site-specific T cell responses in the human brain. Here, we review the updated roles of innate and adaptive immune responses i...
Source: Trends in Parasitology - December 8, 2023 Category: Parasitology Authors: Samuel C Wassmer Tania F de Koning-Ward Georges E R Grau Saparna Pai Source Type: research
The two parasite species formerly known as Plasmodium ovale
Trends Parasitol. 2023 Nov 30:S1471-4922(23)00284-2. doi: 10.1016/j.pt.2023.11.004. Online ahead of print.ABSTRACTPlasmodium ovale was the last of the exclusively human malaria parasites to be described, in 1922, and has remained the least well studied. Beginning in 1995, two divergent forms of the parasite, later termed 'classic' and 'variant', were described. By 2010, it was realised that these forms are two closely related, but genetically distinct and non-recombining species; they were given the names Plasmodium ovale curtisi and Plasmodium ovale wallikeri. Since then, substantial additional data have confirmed that th...
Source: Trends in Parasitology - December 1, 2023 Category: Parasitology Authors: Georges Snounou Paul M Sharp Richard Culleton Source Type: research
The two parasite species formerly known as Plasmodium ovale
Trends Parasitol. 2023 Nov 30:S1471-4922(23)00284-2. doi: 10.1016/j.pt.2023.11.004. Online ahead of print.ABSTRACTPlasmodium ovale was the last of the exclusively human malaria parasites to be described, in 1922, and has remained the least well studied. Beginning in 1995, two divergent forms of the parasite, later termed 'classic' and 'variant', were described. By 2010, it was realised that these forms are two closely related, but genetically distinct and non-recombining species; they were given the names Plasmodium ovale curtisi and Plasmodium ovale wallikeri. Since then, substantial additional data have confirmed that th...
Source: Trends in Parasitology - December 1, 2023 Category: Parasitology Authors: Georges Snounou Paul M Sharp Richard Culleton Source Type: research
The two parasite species formerly known as Plasmodium ovale
Trends Parasitol. 2023 Nov 30:S1471-4922(23)00284-2. doi: 10.1016/j.pt.2023.11.004. Online ahead of print.ABSTRACTPlasmodium ovale was the last of the exclusively human malaria parasites to be described, in 1922, and has remained the least well studied. Beginning in 1995, two divergent forms of the parasite, later termed 'classic' and 'variant', were described. By 2010, it was realised that these forms are two closely related, but genetically distinct and non-recombining species; they were given the names Plasmodium ovale curtisi and Plasmodium ovale wallikeri. Since then, substantial additional data have confirmed that th...
Source: Trends in Parasitology - December 1, 2023 Category: Parasitology Authors: Georges Snounou Paul M Sharp Richard Culleton Source Type: research
The two parasite species formerly known as Plasmodium ovale
Trends Parasitol. 2023 Nov 30:S1471-4922(23)00284-2. doi: 10.1016/j.pt.2023.11.004. Online ahead of print.ABSTRACTPlasmodium ovale was the last of the exclusively human malaria parasites to be described, in 1922, and has remained the least well studied. Beginning in 1995, two divergent forms of the parasite, later termed 'classic' and 'variant', were described. By 2010, it was realised that these forms are two closely related, but genetically distinct and non-recombining species; they were given the names Plasmodium ovale curtisi and Plasmodium ovale wallikeri. Since then, substantial additional data have confirmed that th...
Source: Trends in Parasitology - December 1, 2023 Category: Parasitology Authors: Georges Snounou Paul M Sharp Richard Culleton Source Type: research
The two parasite species formerly known as Plasmodium ovale
Trends Parasitol. 2023 Nov 30:S1471-4922(23)00284-2. doi: 10.1016/j.pt.2023.11.004. Online ahead of print.ABSTRACTPlasmodium ovale was the last of the exclusively human malaria parasites to be described, in 1922, and has remained the least well studied. Beginning in 1995, two divergent forms of the parasite, later termed 'classic' and 'variant', were described. By 2010, it was realised that these forms are two closely related, but genetically distinct and non-recombining species; they were given the names Plasmodium ovale curtisi and Plasmodium ovale wallikeri. Since then, substantial additional data have confirmed that th...
Source: Trends in Parasitology - December 1, 2023 Category: Parasitology Authors: Georges Snounou Paul M Sharp Richard Culleton Source Type: research
