Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Trypanosomes as a magnifying glass for cell and molecular biology
Trends Parasitol. 2023 Sep 5:S1471-4922(23)00195-2. doi: 10.1016/j.pt.2023.08.004. Online ahead of print.ABSTRACTThe African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause worldwide suffering. Diminishing case numbers, due to efficient public health efforts, and recent development of new drug treatments have reduced the need for continued study of T. brucei in a disease context. However, we argue that this pathogen has been instrumental in revolutionary discoveries that ...
Source: Trends in Parasitology - September 7, 2023 Category: Parasitology Authors: Julius Luke š Dave Speijer Alena Z íková Juan D Alfonzo Hassan Hashimi Mark C Field Source Type: research
Trypanosomes as a magnifying glass for cell and molecular biology
Trends Parasitol. 2023 Sep 5:S1471-4922(23)00195-2. doi: 10.1016/j.pt.2023.08.004. Online ahead of print.ABSTRACTThe African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause worldwide suffering. Diminishing case numbers, due to efficient public health efforts, and recent development of new drug treatments have reduced the need for continued study of T. brucei in a disease context. However, we argue that this pathogen has been instrumental in revolutionary discoveries that ...
Source: Trends in Parasitology - September 7, 2023 Category: Parasitology Authors: Julius Luke š Dave Speijer Alena Z íková Juan D Alfonzo Hassan Hashimi Mark C Field Source Type: research
Amblyomma maculatum (Gulf Coast tick)
Trends Parasitol. 2023 Sep 1:S1471-4922(23)00196-4. doi: 10.1016/j.pt.2023.08.005. Online ahead of print.NO ABSTRACTPMID:37661563 | DOI:10.1016/j.pt.2023.08.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 4, 2023 Category: Parasitology Authors: Afsoon Sabet Samuel F Ward Risa Pesapane Source Type: research
Amblyomma maculatum (Gulf Coast tick)
Trends Parasitol. 2023 Sep 1:S1471-4922(23)00196-4. doi: 10.1016/j.pt.2023.08.005. Online ahead of print.NO ABSTRACTPMID:37661563 | DOI:10.1016/j.pt.2023.08.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 4, 2023 Category: Parasitology Authors: Afsoon Sabet Samuel F Ward Risa Pesapane Source Type: research
