Live attenuated anticoccidial vaccines for chickens
Trends Parasitol. 2023 Sep 26:S1471-4922(23)00221-0. doi: 10.1016/j.pt.2023.09.002. Online ahead of print.ABSTRACTChicken coccidiosis, caused by infection with single or multiple Eimeria species, results in significant economic losses to the global poultry industry. Over the past decades, considerable efforts have been made to generate attenuated Eimeria strains, and the use of live attenuated anticoccidial vaccines for disease prevention has achieved tremendous success. In this review, we evaluate the advantages and limitations of the methods of attenuation as well as attenuated Eimeria strains in a historical perspective...
Source: Trends in Parasitology - September 28, 2023 Category: Parasitology Authors: Qing Liu Xianyong Liu Xiaomin Zhao Xing-Quan Zhu Xun Suo Source Type: research
Meloidogyne graminicola
Trends Parasitol. 2023 Sep 26:S1471-4922(23)00214-3. doi: 10.1016/j.pt.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37770353 | DOI:10.1016/j.pt.2023.08.010 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 28, 2023 Category: Parasitology Authors: Satish Namdeo Chavan Tina Kyndt Source Type: research
Autophagy and jasmonate fight nematode blight
Trends Parasitol. 2023 Sep 26:S1471-4922(23)00229-5. doi: 10.1016/j.pt.2023.09.008. Online ahead of print.ABSTRACTPlant-parasitic nematodes (PPNs) pose a serious threat to world crop production and global food security. However, our understanding of the molecular mechanisms underlying plant defense against PPNs remains very limited. Recently, Zou et al. reported that the interplay between autophagy and jasmonate pathways mediates plant immunity against root-knot nematodes.PMID:37770351 | DOI:10.1016/j.pt.2023.09.008 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 28, 2023 Category: Parasitology Authors: Mikayla Carty Chen Wang Daowen Wang Zheng Qing Fu Source Type: research
Live attenuated anticoccidial vaccines for chickens
Trends Parasitol. 2023 Sep 26:S1471-4922(23)00221-0. doi: 10.1016/j.pt.2023.09.002. Online ahead of print.ABSTRACTChicken coccidiosis, caused by infection with single or multiple Eimeria species, results in significant economic losses to the global poultry industry. Over the past decades, considerable efforts have been made to generate attenuated Eimeria strains, and the use of live attenuated anticoccidial vaccines for disease prevention has achieved tremendous success. In this review, we evaluate the advantages and limitations of the methods of attenuation as well as attenuated Eimeria strains in a historical perspective...
Source: Trends in Parasitology - September 28, 2023 Category: Parasitology Authors: Qing Liu Xianyong Liu Xiaomin Zhao Xing-Quan Zhu Xun Suo Source Type: research
Meloidogyne graminicola
Trends Parasitol. 2023 Sep 26:S1471-4922(23)00214-3. doi: 10.1016/j.pt.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37770353 | DOI:10.1016/j.pt.2023.08.010 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 28, 2023 Category: Parasitology Authors: Satish Namdeo Chavan Tina Kyndt Source Type: research
Re-evaluating the mosquito RNAi pathway's influence on arbovirus transmission
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00226-X. doi: 10.1016/j.pt.2023.09.005. Online ahead of print.ABSTRACTWith new RNA interference (RNAi) pathway-deficient mosquitoes, Merkling et al. invite a shift in our view of this pathway's role in regulating arthropod-borne virus (arbovirus) transmission. While loss of RNAi function enhanced early viral replication, little impact on transmission was observed, inviting renewed exploration of molecular barriers to arbovirus transmission.PMID:37758630 | DOI:10.1016/j.pt.2023.09.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Kevin Maringer Source Type: research
Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00213-1. doi: 10.1016/j.pt.2023.08.009. Online ahead of print.ABSTRACTParasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic ...
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Daniel Alfandari Sharon Cadury Mattia I Morandi Neta Regev-Rudzki Source Type: research
Anopheles arabiensis
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00215-5. doi: 10.1016/j.pt.2023.08.011. Online ahead of print.NO ABSTRACTPMID:37758632 | DOI:10.1016/j.pt.2023.08.011 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Temesgen Ashine Dejene Getachew Mulugeta Demisse Neil F Lobo Fitsum G Tadesse Source Type: research
Trypanosomes and complement: more than one way to die?
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00218-0. doi: 10.1016/j.pt.2023.09.001. Online ahead of print.ABSTRACTAfrican trypanosomes show a remarkable ability to survive as extracellular parasites in the blood and tissue spaces of an infected mammal. Throughout the infection they are exposed to the molecules and cells of the immune system, including complement. In this opinion piece, we review decades-worth of evidence about how complement affects African trypanosomes. We highlight the discovery of a trypanosome receptor for complement C3 and we critically assess three recent studies which attempt to provide a structural...
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Alexander D Cook Mark Carrington Matthew K Higgins Source Type: research
Re-evaluating the mosquito RNAi pathway's influence on arbovirus transmission
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00226-X. doi: 10.1016/j.pt.2023.09.005. Online ahead of print.ABSTRACTWith new RNA interference (RNAi) pathway-deficient mosquitoes, Merkling et al. invite a shift in our view of this pathway's role in regulating arthropod-borne virus (arbovirus) transmission. While loss of RNAi function enhanced early viral replication, little impact on transmission was observed, inviting renewed exploration of molecular barriers to arbovirus transmission.PMID:37758630 | DOI:10.1016/j.pt.2023.09.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Kevin Maringer Source Type: research
Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00213-1. doi: 10.1016/j.pt.2023.08.009. Online ahead of print.ABSTRACTParasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic ...
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Daniel Alfandari Sharon Cadury Mattia I Morandi Neta Regev-Rudzki Source Type: research
Anopheles arabiensis
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00215-5. doi: 10.1016/j.pt.2023.08.011. Online ahead of print.NO ABSTRACTPMID:37758632 | DOI:10.1016/j.pt.2023.08.011 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Temesgen Ashine Dejene Getachew Mulugeta Demisse Neil F Lobo Fitsum G Tadesse Source Type: research
Trypanosomes and complement: more than one way to die?
Trends Parasitol. 2023 Sep 25:S1471-4922(23)00218-0. doi: 10.1016/j.pt.2023.09.001. Online ahead of print.ABSTRACTAfrican trypanosomes show a remarkable ability to survive as extracellular parasites in the blood and tissue spaces of an infected mammal. Throughout the infection they are exposed to the molecules and cells of the immune system, including complement. In this opinion piece, we review decades-worth of evidence about how complement affects African trypanosomes. We highlight the discovery of a trypanosome receptor for complement C3 and we critically assess three recent studies which attempt to provide a structural...
Source: Trends in Parasitology - September 27, 2023 Category: Parasitology Authors: Alexander D Cook Mark Carrington Matthew K Higgins Source Type: research
No place to hide! A method for revealing hidden loci of infection
Trends Parasitol. 2023 Sep 22:S1471-4922(23)00225-8. doi: 10.1016/j.pt.2023.09.004. Online ahead of print.ABSTRACTThe capacity to infect and survive in a wide variety of host cells is amongst the strategies that contribute to pathogen persistence. The recent study by Karagiannis et al. presents an unbiased approach to identify infected cells in a visceral leishmaniasis (VL) infection, which revealed parasites in unexpected host cells.PMID:37743113 | DOI:10.1016/j.pt.2023.09.004 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 24, 2023 Category: Parasitology Authors: Peter E Kima Source Type: research
No place to hide! A method for revealing hidden loci of infection
Trends Parasitol. 2023 Sep 22:S1471-4922(23)00225-8. doi: 10.1016/j.pt.2023.09.004. Online ahead of print.ABSTRACTThe capacity to infect and survive in a wide variety of host cells is amongst the strategies that contribute to pathogen persistence. The recent study by Karagiannis et al. presents an unbiased approach to identify infected cells in a visceral leishmaniasis (VL) infection, which revealed parasites in unexpected host cells.PMID:37743113 | DOI:10.1016/j.pt.2023.09.004 (Source: Trends in Parasitology)
Source: Trends in Parasitology - September 24, 2023 Category: Parasitology Authors: Peter E Kima Source Type: research
