Current and upcoming point-of-care diagnostics for schistosomiasis
Trends Parasitol. 2023 Nov 23:S1471-4922(23)00280-5. doi: 10.1016/j.pt.2023.10.005. Online ahead of print.ABSTRACTPoint-of-care (POC) diagnostics are simple and effective portable tools that can be used for fast mapping of helminthic diseases and monitoring control programs. Most POC tests (POCTs) available for schistosomiasis diagnosis are lateral flow immunoassays (LFIAs). The emergence of simple and rapid DNA isolation methods, along with isothermal nucleic acid amplification strategies - for example, loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA) - and recent clustered regu...
Source: Trends in Parasitology - November 24, 2023 Category: Parasitology Authors: Jonas Rivera Yi Mu Catherine A Gordon Malcolm K Jones Guofeng Cheng Pengfei Cai Source Type: research
Advances and challenges in synthetic biology for mosquito control
Trends Parasitol. 2023 Nov 23:S1471-4922(23)00281-7. doi: 10.1016/j.pt.2023.11.001. Online ahead of print.ABSTRACTMosquito-borne illnesses represent a significant global health peril, resulting in approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are continuously expanding their global reach, driven by factors that escalate mosquito populations and pathogen transmission. Innovative control measures are imperative to combat these catastrophic ailments. Conventional approaches, such as eliminating breeding sites and using insecticides, have been helpful, but they face challenges such as inse...
Source: Trends in Parasitology - November 24, 2023 Category: Parasitology Authors: Shih-Che Weng Reem A Masri Omar S Akbari Source Type: research
Current and upcoming point-of-care diagnostics for schistosomiasis
Trends Parasitol. 2023 Nov 23:S1471-4922(23)00280-5. doi: 10.1016/j.pt.2023.10.005. Online ahead of print.ABSTRACTPoint-of-care (POC) diagnostics are simple and effective portable tools that can be used for fast mapping of helminthic diseases and monitoring control programs. Most POC tests (POCTs) available for schistosomiasis diagnosis are lateral flow immunoassays (LFIAs). The emergence of simple and rapid DNA isolation methods, along with isothermal nucleic acid amplification strategies - for example, loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA) - and recent clustered regu...
Source: Trends in Parasitology - November 24, 2023 Category: Parasitology Authors: Jonas Rivera Yi Mu Catherine A Gordon Malcolm K Jones Guofeng Cheng Pengfei Cai Source Type: research
Advances and challenges in synthetic biology for mosquito control
Trends Parasitol. 2023 Nov 23:S1471-4922(23)00281-7. doi: 10.1016/j.pt.2023.11.001. Online ahead of print.ABSTRACTMosquito-borne illnesses represent a significant global health peril, resulting in approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are continuously expanding their global reach, driven by factors that escalate mosquito populations and pathogen transmission. Innovative control measures are imperative to combat these catastrophic ailments. Conventional approaches, such as eliminating breeding sites and using insecticides, have been helpful, but they face challenges such as inse...
Source: Trends in Parasitology - November 24, 2023 Category: Parasitology Authors: Shih-Che Weng Reem A Masri Omar S Akbari Source Type: research
Advances and challenges in synthetic biology for mosquito control
Trends Parasitol. 2023 Nov 23:S1471-4922(23)00281-7. doi: 10.1016/j.pt.2023.11.001. Online ahead of print.ABSTRACTMosquito-borne illnesses represent a significant global health peril, resulting in approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are continuously expanding their global reach, driven by factors that escalate mosquito populations and pathogen transmission. Innovative control measures are imperative to combat these catastrophic ailments. Conventional approaches, such as eliminating breeding sites and using insecticides, have been helpful, but they face challenges such as inse...
Source: Trends in Parasitology - November 24, 2023 Category: Parasitology Authors: Shih-Che Weng Reem A Masri Omar S Akbari Source Type: research
Current and upcoming point-of-care diagnostics for schistosomiasis
Trends Parasitol. 2023 Nov 23:S1471-4922(23)00280-5. doi: 10.1016/j.pt.2023.10.005. Online ahead of print.ABSTRACTPoint-of-care (POC) diagnostics are simple and effective portable tools that can be used for fast mapping of helminthic diseases and monitoring control programs. Most POC tests (POCTs) available for schistosomiasis diagnosis are lateral flow immunoassays (LFIAs). The emergence of simple and rapid DNA isolation methods, along with isothermal nucleic acid amplification strategies - for example, loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA) - and recent clustered regu...
Source: Trends in Parasitology - November 24, 2023 Category: Parasitology Authors: Jonas Rivera Yi Mu Catherine A Gordon Malcolm K Jones Guofeng Cheng Pengfei Cai Source Type: research
Copper in parasitic protists - a hitherto neglected virulence factor
Trends Parasitol. 2023 Nov 21:S1471-4922(23)00278-7. doi: 10.1016/j.pt.2023.10.003. Online ahead of print.ABSTRACTCopper plays a fundamental role in aerobic metabolism, but its role is double-edged, given its toxicity. Our understanding of copper metabolism in parasites remains rudimentary, despite its significance in virulence. Here we discuss how parasitic protists control copper homeostasis and show the potential key players identified by our bioinformatic analysis.PMID:37993308 | DOI:10.1016/j.pt.2023.10.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 22, 2023 Category: Parasitology Authors: Maria Grechnikova Zolt án Füssy Robert Sutak Source Type: research
Copper in parasitic protists - a hitherto neglected virulence factor
Trends Parasitol. 2023 Nov 21:S1471-4922(23)00278-7. doi: 10.1016/j.pt.2023.10.003. Online ahead of print.ABSTRACTCopper plays a fundamental role in aerobic metabolism, but its role is double-edged, given its toxicity. Our understanding of copper metabolism in parasites remains rudimentary, despite its significance in virulence. Here we discuss how parasitic protists control copper homeostasis and show the potential key players identified by our bioinformatic analysis.PMID:37993308 | DOI:10.1016/j.pt.2023.10.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 22, 2023 Category: Parasitology Authors: Maria Grechnikova Zolt án Füssy Robert Sutak Source Type: research
Metarhizium robertsii
Trends Parasitol. 2023 Nov 20:S1471-4922(23)00279-9. doi: 10.1016/j.pt.2023.10.004. Online ahead of print.NO ABSTRACTPMID:37989602 | DOI:10.1016/j.pt.2023.10.004 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 21, 2023 Category: Parasitology Authors: Junmei Shang Shuangxiu Song Chengshu Wang Source Type: research
Metarhizium robertsii
Trends Parasitol. 2023 Nov 20:S1471-4922(23)00279-9. doi: 10.1016/j.pt.2023.10.004. Online ahead of print.NO ABSTRACTPMID:37989602 | DOI:10.1016/j.pt.2023.10.004 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 21, 2023 Category: Parasitology Authors: Junmei Shang Shuangxiu Song Chengshu Wang Source Type: research
Blastocystis: view from atop the gut-brain iceberg
Trends Parasitol. 2023 Nov 16:S1471-4922(23)00255-6. doi: 10.1016/j.pt.2023.10.002. Online ahead of print.ABSTRACTBlastocystis is a common intestinal parasite that has been linked to gut pathology in humans. In this article, we highlight recent publications that offer insight into how these organisms can influence human cognition and the gut microbiome. We also suggest a potential mechanism of action by which this might occur.PMID:37980258 | DOI:10.1016/j.pt.2023.10.002 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 18, 2023 Category: Parasitology Authors: Steven Santino Leonardi Kevin Shyong-Wei Tan Source Type: research
Blastocystis: view from atop the gut-brain iceberg
Trends Parasitol. 2023 Nov 16:S1471-4922(23)00255-6. doi: 10.1016/j.pt.2023.10.002. Online ahead of print.ABSTRACTBlastocystis is a common intestinal parasite that has been linked to gut pathology in humans. In this article, we highlight recent publications that offer insight into how these organisms can influence human cognition and the gut microbiome. We also suggest a potential mechanism of action by which this might occur.PMID:37980258 | DOI:10.1016/j.pt.2023.10.002 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 18, 2023 Category: Parasitology Authors: Steven Santino Leonardi Kevin Shyong-Wei Tan Source Type: research
Blastocystis: view from atop the gut-brain iceberg
Trends Parasitol. 2023 Nov 16:S1471-4922(23)00255-6. doi: 10.1016/j.pt.2023.10.002. Online ahead of print.ABSTRACTBlastocystis is a common intestinal parasite that has been linked to gut pathology in humans. In this article, we highlight recent publications that offer insight into how these organisms can influence human cognition and the gut microbiome. We also suggest a potential mechanism of action by which this might occur.PMID:37980258 | DOI:10.1016/j.pt.2023.10.002 (Source: Trends in Parasitology)
Source: Trends in Parasitology - November 18, 2023 Category: Parasitology Authors: Steven Santino Leonardi Kevin Shyong-Wei Tan Source Type: research
Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Dec;39(12):996-1000. doi: 10.1016/j.pt.2023.09.014. Epub 2023 Oct 19.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Dec;39(12):991-995. doi: 10.1016/j.pt.2023.09.015. Epub 2023 Oct 19.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
