Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
Nanopore sequencing for malaria molecular surveillance: opportunities and challenges
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00235-0. doi: 10.1016/j.pt.2023.09.014. Online ahead of print.ABSTRACTNanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and ultimately counteract emerging threats, such as drug resistance and diagnostic escape. Here, we discuss opportunities and challenges to implementing MMS using nanopore sequencing, highlighting priority areas for technical development and innovation.PMID:37865609 | DOI:10.1016/j.pt.2023.09.014 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: William L Hamilton Deus S Ishengoma Jonathan B Parr Daniel J Bridges Alyssa E Barry Source Type: research
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Trends Parasitol. 2023 Oct 19:S1471-4922(23)00236-2. doi: 10.1016/j.pt.2023.09.015. Online ahead of print.ABSTRACTPlasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.PMID:37865610 | DOI:10.1016/j.pt.2023.09.015 (Source: Trends in Parasitology)
Source: Trends in Parasitology - October 21, 2023 Category: Parasitology Authors: Mirko Singer Friedrich Frischknecht Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections
Trends Parasitol. 2023 Oct 13:S1471-4922(23)00238-6. doi: 10.1016/j.pt.2023.09.017. Online ahead of print.ABSTRACTProtozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed...
Source: Trends in Parasitology - October 15, 2023 Category: Parasitology Authors: Dana A May Fatima Taha Matthew A Child Sarah E Ewald Source Type: research
