Tick salivary glycans - a sugar-coated tick bite

Trends Parasitol. 2023 Oct 12:S1471-4922(23)00233-7. doi: 10.1016/j.pt.2023.09.012. Online ahead of print.ABSTRACTTicks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure successful feeding and pathogen transmission. These salivary proteins are often glycosylated, and glycosylation is potentially critical for the function of these proteins. Some salivary glycans are linked to the phenomenon of red meat allergy - an allergic response to red meat consumption in humans exposed to certain tick species. Tick salivary glycans are also invoked in the phenomenon of acquired tick resistance wherein non-natural host species exposed to tick bites develop an immune response that thwarts subsequent tick feeding. This review dwells on our current knowledge of these two phenomena, thematically linked by salivary glycans.PMID:37838514 | DOI:10.1016/j.pt.2023.09.012
Source: Trends in Parasitology - Category: Parasitology Authors: Source Type: research