The American Journal of Dermatopathology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Slow-Growing Nodule in a Patient With Li-Fraumeni Syndrome: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research
Intranodal Neurofibroma: A Case Report and Literature Review
Conclusions and Importance:
Neurofibroma involving the lymph nodes is rare and this is the first reported case that is shown to diffusely involve the intracapsular space. Furthermore, intranodal neurofibroma can represent a diagnostic pitfall in the evaluation of sentinel lymph nodes for metastatic melanoma. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Primary Cutaneous Epithelioid Inflammatory Myofibroblastic Sarcoma Harboring RANBP2-ALK Fusion: Report of an Exceptional Case
Abstract:
Inflammatory myofibroblastic tumors are rare soft tissue neoplasms with an uncertain biological behavior, derived from fibroblastic and myofibroblastic cells. In rare cases, a peculiar epithelioid phenotypic variant of this tumor is encountered, named epithelioid inflammatory myofibroblastic sarcoma (EIMS). EIMS has overlapping features with inflammatory myofibroblastic tumor but has been correlated with a more aggressive clinical course, a characteristic nuclear membrane or perinuclear anaplastic lymphoma kinase (ALK) immunostaining pattern and a very specific RANBP2-ALK fusion. To date, EIMS has been report...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Merkel Cell Carcinoma In Situ: No More Serendipity?
Abstract:
A 50-year-old man, with a history of extensive sun exposure and multiple previous non-melanoma skin cancers, presented with an asymptomatic 8-× 10-millimeter scaly, skin-colored papule on his right shoulder. Subsequent biopsy and excision revealed epidermal hyperplasia containing large atypical basaloid cells with pagetoid spread. Immunoperoxidase staining for cytokeratin-20 demonstrated a focal perinuclear dot-like pattern, and after excluding other in situ entities, a diagnosis of Merkel cell carcinoma In Situ (MCCIS) was rendered. MCCIS is a very rare entity. Although approximately 18% of Merkel cell carc...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Cutaneous Plasmacytosis and Idiopathic Multicentric Castleman Disease: A Spectrum of Disease?
We present the case of a patient with a several-year history of cutaneous plasmacytosis and evidence of systemic involvement with concurrent idiopathic multicentric Castleman disease (iMCD) involving a lymph node. There have been only a few reports of systemic iMCD preceded by a long, asymptomatic phase of cutaneous manifestations. We discuss the relationship between C/SP and iMCD and elaborate on the pathophysiological overlap of these 2 conditions and potential similarities in their pathogenesis. We suggest that the 2 diseases may represent the same entity presenting on a spectrum, with individuals diagnosed with C/SP at...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Pulse Granuloma–Like Reaction on the Forearm Following an Accidental Wound
We present the first case of a granulomatous reaction with hyaline rings in the skin reaction after an accidental wound and suggest the term pulse granuloma-like to describe lesions that resemble pulse granulomas but with no connection to the gastrointestinal or respiratory tracts. Moreover, we provide a graphic comparison of the hyaline rings observed in our case and the histologic sections of some plants that could have been involved. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
A Rare Case of Pediatric Xanthoma Disseminatum With Diabetes Insipidus and BRAF p.V600E Mutation
Abstract:
Xanthoma disseminatum (XD) is a rare non-Langerhans cell histiocytosis characterized by xanthomatous lesions in the absence of hyperlipidemia. XD usually develops in young adults, and there are rare cases among children. BRAF mutations are frequent in Langerhans cell histiocytosis and Erdheim–Chester disease but absent or only rarely detected in other histiocytosis. Herein, we described a 6-year-old Chinese girl presented with generalized skin lesions and diabetes insipidus for 5 months. There were multiple periorbital xanthelasma with histopathological features of foamy histiocytes infiltration with Touton...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Sarcomatoid Dedifferentiated Melanoma: The Diagnostic Role of Next-Generation Sequencing
Abstract:
Sarcomatoid dedifferentiated melanoma (SDDM) represents a diagnostic challenge as this cutaneous spindle cell melanoma lacks expression of classic melanocytic markers including S100, SOX10, Melan-A, HMB45, and MITF. The expression of the emerging melanoma marker preferentially expressed antigen in melanoma (PRAME) in SDDM is largely unknown. In this article, a case of SDDM arising in association with a nodular melanoma is highlighted. A 65-year-old man presented with a several week history of an ulcerated lesion on the right medial knee. A shave biopsy of the lesion revealed a biphasic neoplasm, which consist...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Moraxella nonliquefaciens–Associated Ecthyma Gangrenosum in a Pediatric Patient With Cancer
Abstract:
In this brief report, we describe a 16-year-old patient with pre–B-cell acute lymphoblastic leukemia on chemotherapy who presented to the emergency department with a fever and “bruise-like” area on his left forearm. Empiric antibiotic therapy was initiated, and initial tissue biopsy demonstrated findings consistent with ecthyma gangrenosum. On day 4 of admission, initial blood cultures grew Moraxella nonliquefaciens, and targeted antibiotic therapy was initiated and continued for a total of 21 days. The patient was discharged after 6 days of in-patient therapy and made a full recovery. M. nonliquefacien...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Brief Report Source Type: research
Melanocytic Panfolliculoma: A Case Report of a Rare Benign Follicular Tumor
We present a case of a rare pigmented PF presenting on actinically damaged skin in an 83-year-old man, which was clinically concerning for malignancy. This tumor arose near an area of atypical squamous proliferation and has evidence of infundibular, outer root sheath, and matrical differentiation and foci of heavy melanin pigmentation and increased melanocytes. We propose the novel designation of “melanocytic PF,” akin to melanocytic matricoma but with panfollicular differentiation. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Brief Report Source Type: research
Cutaneous Actinomycosis of the Perineum in an Immunocompetent Man
We present a case of primary cutaneous actinomycosis of unclear pathogenesis. A 30-year-old-man with no significant medical or surgical history presented to the emergency department with a 2-week history of a tender perineal mass. The patient denied trauma or perforating injury to the area. Examination of the area revealed an indurated, nonfluctuant, erythematous papulonodule located 2 cm from the anus. The lesion was unresponsive to oral and topical antibiotics and was therefore excised. The excision specimen revealed a dense mixed infiltrate partially filling the reticular dermis and extending into the subcutaneous fat. ...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Brief Report Source Type: research
Epidermal Hyperproliferation With Less Prominent Dermal Inflammation Is the Unique Histopathological Feature of the Refractory Lesions in Psoriasis Treated With Ustekinumab
This study suggests that the reduction of dermal inflammation by UST was not sufficient to ameliorate the epidermal changes and implies the role of the interleukin-23–independent downstream cytokine pathway in causing the refractory lesions among patients who responded well to UST. The continuation of UST treatment might not further improve epidermal alterations. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Original Study Source Type: research
Poorly Differentiated Scrotal Carcinoma With Apocrine Immunophenotype
Abstract:
Cutaneous carcinoma of the scrotum is rare with the most common type being squamous cell carcinoma. Here, we report 6 cases of poorly differentiated carcinoma with apocrine immunophenotype. Mean age at presentation was 68 years (range: 31–91 years). Clinical presentation included eczematous rash over mass, scrotal cyst, ulcerated mass, and mass. Tumor size ranged from 1.2 to 5.5 cm (average 2.5 cm). The tumors were solid with involvement of the dermis/hypodermis and composed of cords and nests of eosinophilic cells displaying nuclei with prominent nucleoli and surrounded by desmoplastic stroma. Focal squamo...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Original Study Source Type: research
Painful Purulent Nodules Caused by Mycobacterium at Site of Lipodissolve Injections
We present a 53-year-old woman who received LD injections bilaterally to her proximal arms. One week later, she developed painful nodules at each injection site. She was treated with a 10-day course of trimethoprim/sulfamethoxazole without improvement. An incisional biopsy was performed and showed deep dermal suppurative inflammation with numerous neutrophils and granulomas. Stains for bacteria, fungus, and acid-fast organisms were negative. Cultures for acid-fast bacilli grew Mycobacterium abscessus, sensitive to amikacin and clarithromycin. The patient was subsequently treated with intravenous amikacin, azithromycin, and...
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Original Study Source Type: research
Follicular Melanocytes in Frontal Fibrosing Alopecia: An Immunohistochemical Study With Trichoscopic Correlation
Conclusion:
This study shows follicular melanocyte involvement in FFA, and this finding may be associated with the peripilar white halos observed in trichoscopy. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 24, 2022 Category: Pathology Tags: Original Study Source Type: research
