The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Recurrent Papular Eruption: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis
We present a case of a 62 year old woman with a generalized eruption of erythematous papules on the face, trunk and extremities. Skin biopsies demonstrated a dermal mononuclear cell infiltrate with monocytic (CD4, CD33), histiocytic (CD68, CD163), and dendritic cell (CD1a) immunophenotype but negative for Langerhans' cell marker (CD207). The differential diagnosis included leukemia cutis and ICH, and further workup revealed a normal bone marrow biopsy. To confirm the diagnosis of ICH, next generation sequencing with ETV3-NCOA2 gene fusion was performed and was positive. The patient's condition improved with methotrexate an...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Rare Mimic of a Myxofibrosarcoma: Cutaneous Myxoid Spindle Cell Squamous Cell Carcinoma as a Complication of Chronic Osteomyelitis
Abstract: Myxoid spindle cell squamous cell carcinoma is a rare variant of squamous cell carcinoma that can pose diagnostic challenges because of its unusual morphology. In this article, we report the case of a 68-year-old man who presented with a slow-growing, fungating mass on the right tibia at the site of his long-standing draining sinus tract. Biopsy revealed a malignant spindle cell tumor with prominent myxoid stroma and areas containing thin-walled blood vessels with a curvilinear appearance. The immunohistochemical profile indicated that the neoplastic cells were positive for a variety of keratins (MNF116, Cam ...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement
We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. A review of the literature reveals a plausible mechanism for the induction of persistent JAK signaling in the prese...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Lupus Erythematosus Tumidus Associated With Hemophagocytosis
Abstract: A case of lupus erythematosus tumidus (LET), a subtype of chronic cutaneous lupus erythematosus, in an 85-year-old woman who presented with discrete indurated erythematous plaques over the face and upper chest is described. A skin biopsy showed features in keeping with a diagnosis of LET. Unusually however, the lymphocytic infiltrate contained frequent macrophages that demonstrated hemophagocytosis. Most of the phagocytosed cells were lymphocytes, but there was also evidence of erythrophagocytosis. The presence of conspicuous hemophagocytosis has only rarely been reported in skin biopsies of patients with aut...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Generalized Eruptive Histiocytoma With S100 Protein–Positive Histiocytes and Prominent Eosinophilic Infiltration: A Rare Case Report
We presented this rare case of GEH with such distinctive features to strengthen the awareness of this uncommon form of non-LCH. Classical histopathological and immunological features cannot reliably distinguish GEH from other non-LCH. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Four Case Reports of Cutaneous Sparganosis From Peruvian Amazon
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Brief Report Source Type: research

Basophilic, Thickened Collagen Bundles Seen in Late-Stage Exogenous Ochronosis
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Brief Report Source Type: research

Bulboma: A Benign Keratosis With Differentiation Toward the Lower Segment of the Hair Follicle
Abstract: Bulboma is an appellation proposed to designate a distinctive solitary keratosis exhibiting differentiation toward the bulb of the lower segment of the hair follicle. Bulboma is composed of a papillated proliferation of epithelial cells beneath which is a broad front of interconnected follicular papillae. Overlying these coalescing follicular papillae are follicular germinative cells ascending into matrical cells and supramatrical cells. Cells demonstrating differentiation toward Huxley's and Henle's layer of the inner root sheath at the level of the bulb are present including strikingly bright eosinophilic t...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Original Study Source Type: research

Preferentially Expressed Nuclear Antigen in Melanoma Expression in Melanocytic Activation (Melanotic Macule) of the Nail Unit. A Potential Diagnostic Pitfall? A Study of 3 Cases
In this study, the melanocyte count inferior to 9 melanocytes/mm and the lack of nuclear atypia or confluence of melanocytes permitted a confident diagnosis of MAN. Limitations of our study lie largely in the small number of cases. Despite this, the expression of PRAME in some MAN seems to hamper its diagnostic value in differentiating benign from malignant lesion. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Original Study Source Type: research

Juvenile Xanthogranuloma: A Comparative Immunohistochemical Study of Factor XIIIa, CD11c, and CD4
This study aimed to expand immunophenotypic profile and hence our understanding of the origin of these lesions. The surgical pathology archive was searched for the cases with the pathologic diagnosis of “xanthogranuloma” from 1995 to 2019. Immunohistochemical (IHC) stains were performed for factor XIIIa, CD11c, and CD4. Morphologically, each lesion was classified into early classic, classic, or transitional subtypes. Seventy-seven cases were included with the median age of 7.8 years (male:female 1.3:1). Uniform positivity was noticed for CD4 (n = 77), CD68 (n = 37), CD163 (n = 5), and vimentin (n = 4) stains. Other sta...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Original Study Source Type: research

Immunohistochemistry for Preferentially Expressed Antigen in Melanoma in the Differential Diagnosis of Melanocytic Lesions of the Nail Apparatus
In this study, we evaluated PRAME protein expression in a series of nail unit melanocytic lesions. Twenty-five nail unit melanomas (including small biopsy and amputation specimens) and 32 control benign melanocytic lesions were retrospectively retrieved. Nuclear PRAME staining was scored as percentage and intensity labeling. All melanoma cases showed the nuclear expression of PRAME, which was usually diffuse and strong. In specimens where the neoplastic cells are limited in number, the staining was restricted to the tumor cells, corresponding to the initial H&E impression. All control cases were negative for PRAME expressi...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Original Study Source Type: research

BRAF Immunoexpression Can Be Intralesionally Heterogeneous but BRAF V600E Mutation Status Is Intralesionally Homogeneous and Interlesionally Concordant in Melanoma: A Study of 140 Lesions From 98 Patients
This study sought to confirm the homogeneity of BRAF V600E mutation status in melanoma. BRAF immunohistochemistry was performed on 102 lesions from 60 patients of melanoma with BRAF V600E mutation and 38 negative-control melanoma lesions from 38 patients, both of which were confirmed by real-time PCR or the MassARRAY System. In the positive-control lesions, 9 lesions from 7 patients with preceding BRAF-inhibitor therapy were included. Of the 102 BRAF-mutant lesions, 101 (99.0%) showed diffuse BRAF immunoexpression, but 39 (38.2%) of them showed various heterogeneous intensities. The heterogeneous intensity of immunostainin...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Original Study Source Type: research

Lupus Erythematosus Tumidus: Clinical and Pathological Features in a Series of 20 Patients
Conclusion: LET is a rare, peculiar form of cutaneous lupus erythematosus that only exceptionally evolves to systemic lupus erythematosus . Its clinical–pathologic/immunophenotypical features are very characteristic. The amount of CD123 + PDC is a very helpful feature among the criteria for its diagnosis and seems to be relevant in its pathogenesis. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: CME Article Source Type: research

NEMO-NDAS: A Panniculitis in the Young Representing an Autoinflammatory Disorder in Disguise
Abstract: A 15-month-old full-term boy of African descent with an asymptomatic sickle cell trait presented with episodes of transient erythematous subcutaneous nodules involving the entire body except the face, since 2 weeks of age. The skin lesions evolved to areas of lipoatrophy and hyperpigmentation. An initial skin biopsy, studied at a different department at 2 months, was initially misinterpreted as subcutaneous fat necrosis of the newborn, despite the lack of the typical radiated crystals and needle-shaped clefts characterizing that entity. At 4 months of age, he developed systemic inflammatory manifestations, in...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research