The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Baby Wet Wipes: An Unusual Culprit of Lymphomatoid Contact Dermatitis Mimicking Mycosis Fungoides
Abstract: Lymphomatoid contact dermatitis (LCD) is a rare, benign pseudolymphoma with clinicopathologic features of both allergic contact dermatitis and cutaneous T-cell lymphoma (CTCL). In this article, we report a fascinating case of LCD secondary to chronic baby wet wipe use with clinical features of allergic contact dermatitis and histopathologic changes of mycosis fungoides, a subtype of CTCL. We argue that LCD should be added to the list of mimickers of mycosis fungoides, a subtype of CTCL. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Indeterminant Cell Histiocytosis in a Patient With Hemophagocytic Lymphohistiocytosis
Abstract: Indeterminant cell histiocytosis is a rare disorder, which often presents as a benign, papular eruption without age or sex predilection. It is diagnosed based on histologic findings that are similar to those seen in Langerhans cell histiocytosis without the characteristic Birbeck granules. Hemophagocytic lymphohistiocytosis is a potentially life-threatening disease of immune overactivation that may present with severe symptoms and multiorgan involvement. It can develop because of a primary genetic mutation or secondary to a trigger. Despite their widely different clinical manifestations, both diseases origina...
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Unique Case of Urticarial Skin Eruptions After COVID-19 Vaccination
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Brief Report Source Type: research

Primary Cutaneous Anaplastic Large Cell Lymphoma With 6p25.3 Rearrangement and Epidermotropism
We report the case of a patient with said lymphoma harboring that rearrangement. It presented as a forehead nodule, histologically composed of an intermediate-to-large cell dermal component alongside a small-to-intermediate cell epidermotropic component. After multiple cutaneous and regional lymph node relapses, disease progression has been documented to a distant lymph node, despite local radiotherapy of the cutaneous lesions, chemotherapy, and anti-CD30 therapy, albeit with an indolent course over 6 years. Cases of pcALCL with nonregional lymph node involvement are unusual. Nevertheless, in this case, progression to a di...
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Brief Report Source Type: research

In Vivo Reflectance Confocal Microscopy of Adnexal Tumors: Evaluation of Trichoepithelioma, Sebaceoma, and Fibrofolliculoma
We describe the use of reflectance confocal microscopy in cases of trichoepithelioma, sebaceoma, and fibrofolliculoma and correlate the resulting clinical, histopathological, and confocal microscopy images. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Brief Report Source Type: research

Histopathological and Clinical Analysis of Skin Rashes in Children With Multisystem Inflammatory Syndrome Associated With COVID-19
Discussion: Localized skin lesions appear to be associated with a more severe inflammatory. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Original Study Source Type: research

A Case of CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type Secondary to Chronic Lymphedema
We reported a case of cutaneous diffuse large B-cell lymphoma (DLBCL) (leg type) secondary to chronic lymphedema of the lower limbs. Histopathology showed hyperkeratosis of epidermis, acanthosis, and significant edema in the superficial dermis, with diffuse mononuclear infiltration in the dermis. Immunohistochemical studies revealed the expression of CD5, CD20, Pax-5, Bcl-2, Bcl-6, MUM-1, c-myc, and Ki-67. Therefore, the diagnosis of cutaneous DLBCL (leg type) was made. The study further confirmed the association between lymphoma and lymphedema. Especially, it showed CD5 expression. CD5-positive DLBCLs is a specific subgro...
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Original Study Source Type: research

Diagnostic Value of Plasmacytoid Dendritic Cells in Differentiating Pityriasis Lichenoides et Varioliformis Acuta From Lymphomatoid Papulosis
Abstract: Pityriasis lichenoides et varioliformis acuta (PLEVA) and lymphomatoid papulosis (LyP) can often demonstrate clinical and histopathologic overlap. A recent study demonstrated significant plasmacytoid dendritic cell (pDC) recruitment in lesions of PLEVA, whereas another study reported minimal pDC recruitment in lesions of LyP. To confirm the possible diagnostic value of pDCs in differentiating PLEVA and LyP, we compared the presence and distribution of pDCs and myxovirus protein A (MxA) expression (an indirect assessment of pDC activity). In total, 19 cases of PLEVA (16 patients) and 14 cases of LyP (11 patien...
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Original Study Source Type: research

Morphologic Spectrum of Rhabdomyomatous Mesenchymal Hamartomas (Striated Muscle Hamartomas) in Pediatric Dermatopathology
Conclusions: RMH is a benign hamartomatous lesion with a variable phenotypic spectrum. RMHs predominate in the head and neck. Familiarity with these lesions, including their presentation in less frequent anatomical sites, is important to avoid diagnostic misinterpretations and potential overtreatment. This study represents one of the largest series of RMHs in the literature, including an unusual case in a perianal location. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Original Study Source Type: research

Identification of Hard Ticks in the United States: A Practical Guide for Clinicians and Pathologists
In this study, we provide a simple, practical guide to aid medical practitioners in identifying the most commonly encountered human biting ticks of North America. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: Review Article Source Type: research

The Utility of Myoepithelial Cell Layer Identification in Adnexal Carcinomas
Abstract: The distinction of metastatic carcinomas to the skin (MCS) from cutaneous adnexal carcinomas can pose a significant diagnostic challenge. The differentiation between (MCS) from a primary cutaneous adnexal tumor is one of the most difficult tasks in the field of dermatopathology, and immunohistochemistry has only been partially helpful in solving this problem. In routine diagnostic surgical pathology, it is essential to identify the myoepithelial cell layer by immunohistochemistry to distinguish between an in situ and invasive breast carcinomas and when establishing the presence of microinvasion. The purpose o...
Source: The American Journal of Dermatopathology - February 17, 2022 Category: Pathology Tags: CME Article Source Type: research

Early Erythema Migrans: Do Not Count on Plasma Cells
We present a 67-year-old man whose skin biopsy, taken on day 2 of his eruption, demonstrated a subtle perivascular and interstitial infiltrate of histiocytes without plasma cells. Dermatopathologists need to be aware of this pattern and consider the diagnosis of erythema migrans, despite negative initial serologic testing. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 1, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Rare Case of Epstein-Barr Virus–Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient
We describe a rare case of an EBV-positive T-cell lymphoma presenting in the skin of a 32-year-old woman using adalimumab for neurosarcoidosis. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 1, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Nonhealing Oral Ulcer in a Child: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 1, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Unexpected Abdominal Fat Pad Biopsy: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - February 1, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research