Syphilis Should Be Included in the Differential of Cutaneous Lesions that Have Many CD30 Positive Cells
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

The First Case of Gamma-Delta Primary Cutaneous Anaplastic Large Cell Lymphoma?
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Pigmented Actinic Keratosis Versus In Situ Melanoma: PRAME May Be Helpful
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Scaly Plaques on the Foot: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Unruly Hair with Irregular Cross Sections: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

A Pigmented Nodule on Congenital Melanocytic Nevus: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Necrotizing Infundibular Crystalline Folliculitis—A Case Report of a Rare Entity and Review of the Literature
Abstract: Necrotizing infundibular crystalline folliculitis (NICF) is a rare distinct entity that was introduced in 1999. It typically presents with numerous eruptive waxy papules on the forehead and/or the upper back in adults in their fifth to seventh decade of life. The pathogenesis is unknown to date, but yeast and bacterial infection of the follicular ostia seems to contribute to the development. More recently, NICF has occasionally been observed as a side effect of targeted antitumoral therapy. Histopathologically, NICF is characterized by dilated follicular ostia filled with pale filamentous and birefringent mat...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Primary Cutaneous Malignant Perivascular Epithelioid Cell Tumor Mimicking Undifferentiated Pleomorphic Sarcoma: A Report of a Rare Entity
Abstract: Primary cutaneous malignant perivascular epithelioid cell tumor (PEComa) is a rare and potentially aggressive neoplasm. In this article, we report the case of a 34-year-old man who initially presented with a 3-cm mass involving the skin and soft tissue of the right shoulder that, over 3 months, enlarged to 12 cm. Histologic examination of the mass revealed an infiltrative neoplasm with features resembling an undifferentiated pleomorphic sarcoma, including sheets of pleomorphic cells with abundant atypical mitoses and necrosis. Immunohistochemical evaluation showed features suggestive of PEComa. Next-generatio...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Spindle Cell/Pleomorphic Lipoma With Trichodiscoma-like Epithelial Hyperplasia Mimicking Atypical Fibroxanthoma/Pleomorphic Dermal Sarcoma
Abstract: A 58-year-old man presented with a lesion on the nose suspicious for basal cell carcinoma. An initial biopsy specimen reviewed at an outside institution showed a cytologically atypical spindle cell proliferation that lacked expression of cytokeratins or melanocytic markers. The resulting differential diagnosis included atypical fibroxanthoma and pleomorphic dermal sarcoma. Histopathologic examination of the excision specimen at our institution revealed an intradermal pleomorphic and spindle cell tumor which extended into underlying skeletal muscle. The tumor was associated with a fibromyxoid stroma, scattered...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Cutaneous Ossifying Amyloidoma
We report the case of a 75-year-old woman with voluminous and strikingly ossifying AL-type amyloidoma in the left pretibial skin. Her medical history included excision of hepatic hydatidic cysts 25 years prior and diffuse large B-cell lymphoma of the left parotid gland 8 years prior treated with chemotherapy and radiotherapy with complete response. After the diagnosis of amyloidoma, an extension study with cervical, chest, abdominal, and pelvic TC was performed, with no additional lesions found. Serum and protein electrophoresis revealed elevations in kappa light chain and IgA immunoglobulin levels but did not reveal monoc...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Cutaneous Malakoplakia of the Right Cheek in an Immunocompromised Man
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Brief Report Source Type: research

Foamy Cell Histiocytosis Is a Diagnostic Pitfall: A Case Report of Xanthomatosis Secondary to Sitosterolemia Mimicking Progressive Nodular Histiocytosis
We report a noteworthy case of a 10-year-old girl who presented with papular and nodular lesions on the skin that were clinically and histologically mistaken for progressive nodular histiocytosis. During the clinical management of the patient, the high lipid levels raised the suspicion of lipid metabolism disease and helped us to make the correct diagnosis of sitosterolemia. In sitosterolemia, proper management such as restriction of plant sterol intake and administration of cholesterol absorption inhibitor can improve prognosis. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Brief Report Source Type: research

Follicular Porokeratoma: Report of a New Variant of Porokeratoma (Porokeratotic Acanthoma) and Literature Review
We report a new case of porokeratoma involving hair follicles, a finding that has been reported in only one of the previously published cases. Analogous to follicular porokeratosis, a form of porokeratosis involving hair follicles, we have termed this lesion “follicular porokeratoma.” A review of all 23 published cases (including the present case) is also provided. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Brief Report Source Type: research

Actionable Mutation Profile of Sun-Protected Melanomas in South America
This study reveals new actionable mutations that are potential targets in the treatment of photo-protected melanomas. Additional studies on more of these melanoma subtypes could confirm our findings and identify new mutations. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Original Study Source Type: research

PRAME Expression in Junctional Melanocytic Proliferations of the Conjunctiva: A Potential Biomarker for Primary Acquired Melanosis/Conjunctival Melanocytic Intraepithelial Lesions
Abstract: Conjunctival melanocytic proliferations are diagnostically challenging, often complicated by small specimen size, and are separated into 3 broad categories. The first group includes benign nevi and primary acquired melanosis (PAM) without atypia. The second group includes junctional melanocytic proliferations with a risk of progression to invasive melanoma (PAM with atypia). The last category is conjunctival melanoma, of which 65% of tumors arise in the setting of PAM with atypia. Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry has been widely adopted to differentiate cutaneous nevi ...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Original Study Source Type: research