The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Next-Generation Sequencing Reveals a New Class of Melanocytic Neoplasms With Hybrid Genomic Features of PEM Including Protein Kinase R 1 Alpha Gene Inactivation and Spitz Tumor–Defining Protein Kinase Fusions
Conclusions: PRKAR1a-inactivated/Spitz fusion–associated PEMs and PRKCB fusion–associated PEMs represent 2 new molecular classes of PEM. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - July 25, 2022 Category: Pathology Tags: Original Study Source Type: research

Subtlety of Granulomatous Mycosis Fungoides: A Retrospective Case Series Study and Proposal of Helpful Multimodal Diagnostic Approach With Literature Review
In conclusion, GMF has subtle or absent epidermotropism and variable granulomatous reaction; thus, the diagnosis requires a multimodal approach, and our proposed algorithm provides a framework to approach this diagnostic challenge. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - July 25, 2022 Category: Pathology Tags: Original Study Source Type: research

Pigmented Purpuric Dermatosis of the Hand: Clinicopathologic Analysis of Six Cases With Review of the Literature
We present 6 new cases of PPD involving the hand and review 17 previously reported cases in the literature. All cases in our series were unilateral and localized to the dorsum of the hand. PPD was considered clinically in only 2 of these cases. Histopathologic examination revealed hallmark features of PPD, namely a superficial perivascular lymphocytic infiltrate and extravasated erythrocytes. Previous reports of PPD involving the hand described concurrent involvement of other anatomic sites in most cases; only 4 cases (24%) were confined to the hands. Histopathologic descriptions of these reported cases were compatible wit...
Source: The American Journal of Dermatopathology - July 25, 2022 Category: Pathology Tags: Original Study Source Type: research

Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis
Abstract: Trichilemmoma is a benign cutaneous neoplasm that recapitulates the outer root sheath of the hair follicle. Trichilemmomas may occur sporadically or in association with Cowden syndrome, which is characterized by germline mutations in the lipid phosphatase PTEN (phosphatase and tensin homolog on chromosome 10). Interestingly, most sporadic trichilemmomas do not show PTEN aberrations, but rather activating mutations in HRAS. Despite these important advances, a comprehensive genetic analysis of trichilemmoma has not been reported. Here, we used a next-generation DNA sequencing platform to study 9 sporadic trichi...
Source: The American Journal of Dermatopathology - July 25, 2022 Category: Pathology Tags: CME Article Source Type: research

A Rare Case of Primary Cutaneous Signet-Ring Cell Melanoma With Discrepant Findings on Gene Expression Profiling and Chromosomal Microarray Analysis
In this report, we aim to add to the literature by describing the histomorphological, immunophenotypic, gene expression, and cytogenetic findings in 1 recently encountered case. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Varicella Zoster With Pemphigus-like Reaction
We present a case of a 55-year-old man with a rash on his right foot that was biopsied and diagnosed as a Varicella Zoster virus infection with an accompanying positive immunohistochemical study with antiviral antibodies. He concomitantly suffered from a Varicella Zoster virus meningitis. The skin biopsies not only showed clear histologic signs of viral cytopathic effects but also showed intercellular IgG and C3 intraepidermal staining by direct immunofluorescence study, findings which are typically consistent with pemphigus vulgaris. However, the patient did not have any history of pemphigus; there was no mucosal involvem...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Fast-Growing Tumor on the Head of an Elderly Woman: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Multiple Nodules on the Bilateral Lower Extremities: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Recurrent Papular Eruption: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Tumoral Melanosis and Separate Granulomatous Inflammation due to Talimogene Laherparepvec
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

The Probable Mechanism of Hair Loss in Patients With COVID-19
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Injection-Site Reaction to Brodalumab in a Psoriasis Patient: Report of Clinicopathological Findings
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Dermatology Essentials: Second Edition
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Book Review Source Type: research

A Fast-Growing Tumor on the Head of an Elderly Woman: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Multiple Nodules on the Bilateral Lower Extremities: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research