The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Pilomatrical Acanthoma: An Extremely Rare Intraepidermal Variant of Pilomatricoma
Abstract: Pilomatrical differentiation can be observed in a variety of benign and malignant tumors, with the most common prototype being pilomatricoma. Pilomatricoma often presents in the deep dermis or subcutis, and the sole involvement of epidermis is extremely rare. In our current case series, specimens from 5 patients were included with an average age of 68 years. All lesions presented as solitary verrucous or keratotic papules on the extremities, with 1 lesion having a prominent horn. All lesions have a variable mixture of basaloid matrical cells and shadow cells, and all lesions express β-catenin (strong nuclear...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Brief Report Source Type: research

Sinonasal Mucosal Melanoma: An Update and Review of the Literature
Abstract: Primary sinonasal mucosal melanoma (SNMM) is an aggressive tumor with high metastatic potential and poor outcomes. Presenting symptoms are nonspecific, and the nasal cavity is the most common site of origin followed by the maxillary and ethmoid sinuses. Histopathologically, SNMMs are pleomorphic and predominantly composed of epithelioid cell type. Identifying these tumors requires a high index of suspicion for melanoma and the use of a panel of immunohistochemical markers when typical histopathological features are missing. Not infrequently, these tumors are undifferentiated and/or amelanotic. Currently, SNMM...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Review Article Source Type: research

Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma
This study aimed to evaluate the presence of TRM cells in human skin melanocytic lesions, representing the spectrum from healthy skin to metastatic melanoma. FFPE sections from healthy skin, sun-exposed skin, benign nevi, lentigo maligna (LM), primary LM melanoma, and primary cutaneous and metastatic melanoma were analyzed by immunohistochemistry. The number of infiltrating cells expressing TRM-associated markers, CD3, CD4, CD8, CD69, CD103, and CD49a, was quantified by digital analyses. Multiplex immunofluorescence was performed to analyze coexpression of TRM cell markers. More T cells and CD69+ cells were found in melano...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Original Study Source Type: research

Dermatologists' Impressions of Spontaneously Regressing Verruca Plana Histopathology
Abstract: Verruca plana in its regressing phase exhibits clinical and histological features distinct from classic verruca plana, but the ways in which these features should inform treatment plans are still under investigation. We conducted a retrospective single-center analysis of 25 patients with features of classic verruca plana, or plane warts, who exhibited self-remission within 4 weeks of skin biopsy. Measures included lesion sites, clinical findings preceding regression, and histological analysis. Histological analysis involved review by 2 dermatologists followed by impressions given by 4 board-certified dermatol...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Original Study Source Type: research

PRAME Expression in Challenging Dermal Melanocytic Neoplasms and Soft Tissue Tumors With Melanocytic Differentiation
Abstract: Preferentially expressed antigen in melanoma (PRAME) is an immunohistochemical biomarker that is diffusely expressed in most cutaneous melanomas and is negative in most benign nevi. Histologically challenging dermal melanocytic neoplasms, such as cellular blue nevi (CBN) and deep penetrating nevi (DPN), and soft tissue tumors with melanocytic differentiation, such as clear cell sarcoma and perivascular epithelioid cell tumor, may resemble primary or metastatic melanoma. PRAME immunohistochemistry (IHC) was applied to archived formalin-fixed, paraffin-embedded specimens of various dermal melanocytic neoplasms ...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Original Study Source Type: research

Eosinophilic Pustular Folliculitis of Infancy: A Histologic Assessment of 43 Cases
Abstract: Eosinophilic pustular folliculitis of infancy is a sterile, inflammatory dermatosis that mainly affects children younger than 36 months. The underlying physiopathologic mechanism is unclear. Clinical diagnosis is challenging, and a skin biopsy may be necessary. The literature data are sometimes contradictory, and a histologic series of eosinophilic pustular folliculitis of infancy cases has not been previously published. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: CME Article Source Type: research

Cutaneous Neurocristic Hamartoma Mimicking Basal Cell Carcinoma in a Patient With Xeroderma Pigmentosum
Abstract: Neurocristic hamartomas (NCH) of cutaneous origin are especially rare congenital or acquired neoplasms that often arise through aberrant embryologic development of pluripotent neural crest cells. Clinically, they often present as pigmented macules or papules on the scalp with associated alopecia. NCHs are characterized histopathologically by dermal melanocytic, fibroblastic, and neurosustentacular components. Correct identification of this etiology is critical because of potential for malignant transformation, particularly in acquired NCHs. Our patient was a 6-year-old girl with xeroderma pigmentosum and conf...
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Combined Poroma and Verruca Plantaris
Abstract: A 76-year-old female patient presented with a peculiar new exophytic-appearing, flesh-colored skin lesion on her left hallux. Owing to its atypical appearance, the neoplasm was biopsied. Histologic sections demonstrated numerous thickened, anastomosing cord-like structures composed of bland appearing adnexal keratinocytes attached to the epidermis and extending into the superficial dermis. Nearby areas exhibited papillomatosis, epidermal acanthosis, dense hyperparakeratosis, hypergranulosis, and superficial koilocytes, findings consistent with a verruca plantaris. A p16 stain was positive in many of the super...
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Ulcerative Lesions and Diarrhea: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Rash and Corneal Ulceration: A Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Multiple Scrotal Skin Papules: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Atypical Vascular Lesions After Radiotherapy: A Case Series
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Fibrillary “Fern-Like” Immunoglobulin A Deposition in Dermatitis Herpetiformis
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Ulcerative Lesions and Diarrhea: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Rash and Corneal Ulceration: A Challenge: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 22, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research