The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Syphilitic Folliculitis: A Case Report With Demonstration of Spirochetes Showing Follicular Epitheliotropism
We report a case of a 59-year-old man presenting with a widespread follicular-based papular rash with a several-month history of myalgias, lymphadenopathy, fatigue, and weight loss who was diagnosed with acute syphilitic folliculitis by tissue biopsy analysis with immunohistochemical demonstration of spirochetes in hair follicle epithelium. Serologic analysis also showed evidence of Treponema sp. infection. Owing to the rising number of syphilis cases in the last decade, it is important to recognize classic cutaneous findings of syphilis in addition to unusual presentations such as syphilitic folliculitis. (Source: The Ame...
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Pigmented Multinucleate Cell Angiohistiocytoma: First Case
We present a pigmented MCAH with cytoplasmic brownish pigment, which was positive with a Masson–Fontana stain and negative with an iron stain, consistent with melanin, in a 33-year-old woman with multiple papules and plaques on the right elbow, right jawline, and left flank. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Rare Concurrence of Alopecia Areata in the Setting of the Lipedematous Scalp
We report a case of alopecia areata with LS, which may be misdiagnosed as LA. However, the histopathologic features showed a thickened subcutaneous fat layer and hair bulb inflammation. Hair regrowth was appreciable after treatment with topical steroids, minoxidil, oral compound glycyrrhizin, and vitamin D. This case report aims to show that LS and alopecia areata may coexist, and histopathologic examination is necessary for precise diagnosis. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Brief Report Source Type: research

Epidermotropic Cutaneous Metastasis of Colonic Adenocarcinoma Presenting as a Sister Mary Joseph Nodule
We present a case of epidermotropic cutaneous metastasis of colorectal adenocarcinoma presenting as a Sister Mary Joseph nodule, an extremely rare occurrence that has not been well-documented in the literature. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Brief Report Source Type: research

Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature
Conclusion: Facial dermatofibromas are rare and are difficult to fully excise. Cellular type and subcutaneous or muscular involvement are common in these cases and tend to have higher local recurrence rate than other nonfacial dermatofibromas. Wider excisions might be necessary for complete excision. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Review Article Source Type: research

Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi
In this study, we used 7829 cases that had been histopathologically diagnosed as MMCNs of the face, neck, and scalp at the Department of Dermatopathology, Nippon Medical School Musashi Kosugi Hospital and observed whether features of FSCH accompanied them. Of the resected MMCNs, 274 of 7829 (3%) were accompanied by features of FSCH. The nose was the most common resection site, followed by the eyebrow area, ear, and cheek. The coexistence rate for the nevi on the nose and features of FSCH was as high as 10%–20%, and its rate increased with age. We found that FSCH appears mostly in seborrheic areas, such as the nose and ch...
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Original Study Source Type: research

Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis
We report 5 cases of cutaneous GN in adult patients; all of which were discovered incidentally in the immediate vicinity of epidermal hyperplasia. A review of the literature demonstrates the current—although likely imperfect—understanding of the etiopathogenesis of both SK and GN in the skin. We explore the putative pathophysiologies of other common, well-characterized skin lesions and, taking them into account, provide rationale for the coexistence of cutaneous GN with overlying SK and SK-like epidermal changes. However, we ultimately acknowledge a dilemma of causality and, given the rarity of their co-occurrence, obj...
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Original Study Source Type: research

MAML2 Gene Rearrangement Occurs in Nearly All Hidradenomas: A Reappraisal in a Series of 20 Cases
Abstract: Hidradenoma is a benign cutaneous adnexal neoplasm that occurs across a wide age range and at a variety of anatomic sites. Its most characteristic morphologic feature is the presence of diverse cell types including squamoid, clear, plasmacytoid, and mucinous cells. Hidradenoma is morphologically and molecularly similar to mucoepidermoid carcinoma, and both tumors are characterized by recurrent CRTC1-MAML2 cytogenetic translocations. Previous studies have suggested that approximately half of hidradenomas possess this translocation. This finding raised the question of whether translocation-negative hidradenomas...
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Original Study Source Type: research

Major Histotypes in Skin Melanoma: Nodular and Acral Lentiginous Melanomas Are Poor Prognostic Factors for Relapse and Survival
In conclusion, we observed that the histologic subtype was an independent predictor for relapse and outcome for cutaneous melanoma patients. Both NM and ALM had unfavorable prognoses, and they were associated with known poor pathological and clinical indicators. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: Original Study Source Type: research

A Case Series With Acquired Dermal Melanocytosis: A Retrospective Study From 2001 to 2018
This study aimed to evaluate ADM in different body locations using different immunohistochemical and chemical staining techniques. This retrospective case series includes consecutive patients confirmed as ADM by biopsy between 2001 and 2018. Patient data and archival images were used to determine the pattern and duration of skin lesions, as confirmed by data analysis of immunohistopathological staining of skin biopsy specimens. A total of 22 ADM patients were included with mean age at diagnosis of 47 years, and 63.6% were female. The most common site was limbs (36.4%), followed by face (27.3%), trunk (22.7%), and scalp (13...
Source: The American Journal of Dermatopathology - October 21, 2022 Category: Pathology Tags: CME Article Source Type: research

Dermal Cystine Crystals: An Incidental Finding During Mohs Surgery
We present a case of a 48-year-old woman with a history of cystinosis and squamous cell carcinoma treated with Mohs micrographic surgery where widespread deposition of cystine crystals were noted on frozen sections of the Mohs layers. These were rectangular to polygonal refractile crystals within the cytoplasm of dermal fibroblasts and macrophages which were highlighted by polarized light microscopy. This case illustrates the use of frozen section processing to demonstrate the presence of intracellular cystine crystals. Moreover, because patients with cystinosis may be predisposed to developing carcinomas postrenal transpl...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics
Abstract: Chondromyxoid metaplasia can rarely lead to the formation of a distinctive tumor-like proliferation in the plantar foot. This is thought to represent a reactive or reparative process, possibly due to chronic trauma. For the unwary dermatopathologist, this could represent a diagnostic challenge. Herein, we review the clinical, histopathological, and molecular presentation of an athletic 17-year-old boy with a soft tissue mass arising in the right plantar foot. Microscopic examination showed a relatively circumscribed proliferation of spindle cells with abundant chondromyxoid stroma, hyalinization, and diffuse ...
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Scaly Plaques on the Foot: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Unruly Hair With Irregular Cross Sections: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

A Pigmented Nodule on Congenital Melanocytic Nevus: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - September 25, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research