The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Acantholytic Dyskeratosis Post-COVID Vaccination
Abstract: Acantholytic dyskeratosis mimicking Grover disease as a cutaneous manifestation of a side effect to the Moderna (mRNA-1273) COVID vaccine is rare with only one documented case in the literature to date. Herein, we present a case of an eruptive, erythematous, vesiculopapular rash developing in a patient after the Moderna vaccine. Histopathology of a representative biopsy [x2, done 8 weeks apart] of the rash revealed similar histopathologic findings of patchy suprabasal acantholysis with dyskeratotic keratinocytes and an underlying inflammatory infiltrate of lymphocytes and neutrophils. Direct immunofluorescenc...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

A 72-Year-Old Woman With Hemorrhagic Bullae Over the Dorsal Hand: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Multiple Recurrent Plaques on Truck and Face: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Pure and Mixed Desmoplastic Melanoma Subtypes Exhibit Distinct Genetic Drivers
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Mycobacterium leprae Immunostaining Pitfall
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

A 72-Year-Old Woman With Hemorrhagic Bullae Over the Dorsal Hand: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Multiple Recurrent Plaques on the Truck and Face: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Granulomatous Dermatitis Heralding Myelodisplastic/Myeloproliferative Neoplasms. Neoplastic or Reactive Cells? A Study of 2 Cases
We present here 2 cases with granulomatous skin infiltrates preceding the diagnosis of myelodysplastic/myeloproliferative neoplasms. In one of them, the same IDH2 mutation was detected in granulomatous lesions on the skin and in the bone marrow. This was performed by pyrosequencing instead of next-generation sequencing, with improved cost-effectiveness. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Silicone Granulomas at the Peripheral Intravenous Cannula Puncture Site
Abstract: Different adverse reactions to silicone present in cosmetic fillers, implants, or medical devices have been reported. The granulomatous reaction on the injection site due to catheters' silicone coating is an infrequent complication, which may be clinically difficult to suspect. Although the definitive diagnosis requires identification of the silicone with techniques such as X-ray spectroscopy, the possibility of involvement of silicone, as well as the histopathologic demonstration of granulomas with refractile, nonpolarizable, and nonstainable material strongly suggests this diagnosis. Moreover, the use of a ...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Case of Indeterminate Cutaneous Dendritic Cell Tumors in the Setting of Chronic Myelomonocytic Leukemia
Abstract: Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic stem cell neoplasm. Indeterminate dendritic cell neoplasm (IDCN) is an extraordinarily rare histiocytosis that may manifest secondarily to CMML. A 75-year-old man with a 2-year history of CMML presented for multiple cutaneous lesions on his head and neck. Biopsy results yielded a dense diffuse infiltrate of large pleomorphic cells, which were positive for CD1a, S100, and CD56 with weak positivity for CD43 and CD68. Given his history of CMML, the patient was diagnosed with IDCN. This may indicate a progression of his CMML or transformation to acute...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Histological Transformation and Clonal Relationship of Subcutaneous Marginal Zone B-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
This article reports a unique case of marginal zone lymphoma (MZL) limited to skin/subcutis (confirmed with PET-CT) that subsequently developed DLBCL, followed by nodal MZL. We explored phenotypic, molecular genetic, and cytogenetic findings in subcutaneous MZL with HT to DLBCL and subsequent progression to systemic MZL. Shared clonal peaks between the tumors were demonstrated through immunoglobulin heavy chain PCR, and genomic microarray analysis revealed both unique genomic abnormalities and shared regions of copy-neutral loss of heterozygosity in all specimens. BCL-2 expression was present in the original subcutaneous M...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Rare Palisading Variant of Dermatofibroma
We report a case of a 33-year-old Hispanic woman who presented with a history of an asymptomatic, slow-growing lesion on her left arm present since her teenage years. Physical examination revealed a solitary, firm brown-to-white 5-mm papule on the left upper arm. A biopsy was performed and revealed a proliferation of spindle cells palisading around areas of hyalinized collagen. The many histologic variants of DF can sometimes create diagnostic confusion. Previously described cases of palisading DFs in the literature showed palisading resembling Verocay bodies and thus raising concern for a schwannoma or other neoplasm that...
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Acquired Elastotic Hemangioma With Multiple Lesions: A Case Report
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - May 21, 2022 Category: Pathology Tags: Brief Report Source Type: research