A Rare Case of Primary Cutaneous Signet-Ring Cell Melanoma With Discrepant Findings on Gene Expression Profiling and Chromosomal Microarray Analysis
In this report, we aim to add to the literature by describing the histomorphological, immunophenotypic, gene expression, and cytogenetic findings in 1 recently encountered case. (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Varicella Zoster With Pemphigus-like Reaction
We present a case of a 55-year-old man with a rash on his right foot that was biopsied and diagnosed as a Varicella Zoster virus infection with an accompanying positive immunohistochemical study with antiviral antibodies. He concomitantly suffered from a Varicella Zoster virus meningitis. The skin biopsies not only showed clear histologic signs of viral cytopathic effects but also showed intercellular IgG and C3 intraepidermal staining by direct immunofluorescence study, findings which are typically consistent with pemphigus vulgaris. However, the patient did not have any history of pemphigus; there was no mucosal involvem...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Fast-Growing Tumor on the Head of an Elderly Woman: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Multiple Nodules on the Bilateral Lower Extremities: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Recurrent Papular Eruption: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Tumoral Melanosis and Separate Granulomatous Inflammation due to Talimogene Laherparepvec
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

The Probable Mechanism of Hair Loss in Patients With COVID-19
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Injection-Site Reaction to Brodalumab in a Psoriasis Patient: Report of Clinicopathological Findings
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Letters to the Editor Source Type: research

Dermatology Essentials: Second Edition
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Book Review Source Type: research

A Fast-Growing Tumor on the Head of an Elderly Woman: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Multiple Nodules on the Bilateral Lower Extremities: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Recurrent Papular Eruption: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis
We present a case of a 62 year old woman with a generalized eruption of erythematous papules on the face, trunk and extremities. Skin biopsies demonstrated a dermal mononuclear cell infiltrate with monocytic (CD4, CD33), histiocytic (CD68, CD163), and dendritic cell (CD1a) immunophenotype but negative for Langerhans' cell marker (CD207). The differential diagnosis included leukemia cutis and ICH, and further workup revealed a normal bone marrow biopsy. To confirm the diagnosis of ICH, next generation sequencing with ETV3-NCOA2 gene fusion was performed and was positive. The patient's condition improved with methotrexate an...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Rare Mimic of a Myxofibrosarcoma: Cutaneous Myxoid Spindle Cell Squamous Cell Carcinoma as a Complication of Chronic Osteomyelitis
Abstract: Myxoid spindle cell squamous cell carcinoma is a rare variant of squamous cell carcinoma that can pose diagnostic challenges because of its unusual morphology. In this article, we report the case of a 68-year-old man who presented with a slow-growing, fungating mass on the right tibia at the site of his long-standing draining sinus tract. Biopsy revealed a malignant spindle cell tumor with prominent myxoid stroma and areas containing thin-walled blood vessels with a curvilinear appearance. The immunohistochemical profile indicated that the neoplastic cells were positive for a variety of keratins (MNF116, Cam ...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement
We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. A review of the literature reveals a plausible mechanism for the induction of persistent JAK signaling in the prese...
Source: The American Journal of Dermatopathology - June 19, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research