The American Journal of Dermatopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Utility of Insulinoma-Associated Protein 1 (INSM1) and Mucin 2 (MUC2) Immunohistochemistry in the Distinction of Endocrine Mucin-Producing Sweat Gland Carcinoma From Morphologic Mimics
Abstract: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade adnexal malignancy with a predilection for the eyelids of elderly White women, which is associated with invasive mucinous carcinoma with endocrine features in one-third of cases. EMPSGC is characterized by the presence of neuroendocrine differentiation and mucin production. However, EMPSGC displays a variety of architectural patterns including solid, cribriform, papillary, and cystic growth. In addition, EMPSGC may also display nonendocrine cytologic features, such as apocrine change. Because of their variable appearance, EMPSGC can ...
Source: The American Journal of Dermatopathology - February 1, 2022 Category: Pathology Tags: Original Study Source Type: research

Pathological and Immunohistochemical Characteristics of Granuloma and Lymphatics in Cheilitis Granulomatosa
Abstract: Cheilitis granulomatosa (CG) is an idiopathic, rare, and chronic granulomatous disorder involving the lips. We characterized the pathological and immunohistopathological findings of these granulomas and their relationship with the lymphatic vessels. Pathologically confirmed cases of primary CG from 2001 to 2016 were collected. Cases of inflammatory cheilitis without the presence of granuloma were included in the control group. Demographic data, clinical presentation, response to therapy, and pathological differences were compared. Periodic acid–Schiff and acid-fast stains excluded patients having infections...
Source: The American Journal of Dermatopathology - February 1, 2022 Category: Pathology Tags: CME Article Source Type: research

Epithelioid Fibrous Histiocytoma With Chondroblastoma-Like Features: A Report of a Rare Entity and Discussion of Related Diagnostic Challenges
Abstract: Epithelioid fibrous histiocytoma (EFH) is an uncommon benign skin lesion. It is distinct from FH by virtue of its recurrent anaplastic lymphoma kinase (ALK) gene rearrangements and immunohistochemical expression of ALK protein. It often poses a challenge in interpretation. Clinically, it is characterized by a flesh-colored papule/nodule on an extremity of a young to middle-aged individual. Microscopically, it is represented by a circumscribed dermal papule/nodule composed of sheets of plump epithelioid cells, forming whorled aggregates around numerous intralesional vessels. Immunohistochemistry, notably ALK p...
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Doubly Misdiagnosed: Exophiala Masquerading as Squamous Cell Carcinoma and Chromoblastomycosis
Abstract: Deep cutaneous fungal infections (DCFI) can arise in the setting of skin trauma and immunosuppression. DCFI may be secondary to chromoblastomycosis, which is typically characterized by pseudoepitheliomatous hyperplasia histologically and can be mistaken for squamous cell carcinoma. In addition, “copper penny” spore–like pigmented yeast forms on Grocott's methenamine silver stain can suggest chromoblastomycosis, but this finding is not specific. By contrast, phaeohyphomycosis characteristically exhibits circumscribed pseudocyst or abscess on histopathology, and both yeast and hyphae can be seen. Our case...
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Chronic Atrophic Scar-like Plaque: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Pediatric Pigmented Fibrosarcomatous Dermatofibrosarcoma Protuberans: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Curious Condylomatous Lesion on the Perianal Skin: The Great Imitator Struck Again: Challenge
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Source Type: research

Cutaneous Lymphocytic Vasculitis After Administration of the Second Dose of AZD1222 (Oxford–AstraZeneca) Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination: Casuality or Causality?
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Letters to the Editor Source Type: research

Primary and Secondary Livedoid Vasculopathy: A Report of 2 Cases
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Letters to the Editor Source Type: research

Chronic Atrophic Scar-Like Plaque: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Pediatric Pigmented Fibrosarcomatous Dermatofibrosarcoma Protuberans: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Curious Condylomatous Lesion on the Perianal Skin—The Great Imitator Struck Again: Answer
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Podophyllotoxin Cytological Effects on the Epidermis in Condyloma Acuminatum
Abstract: Podophyllotoxin (PPT) is used to treat condylomata acuminata and works by destabilizing microtubules within epithelial cells, leading to mitotic arrest in metaphase. PPT-induced changes to the epidermis can cause histological findings mimicking dysplasia. Here, we present a case of vulvar condyloma acuminatum treated with PPT, showing ballooning degeneration, necrotic keratinocytes, and mitotic figures. PPT-treated skin may resemble dysplasia or squamous cell carcinoma in situ due to dyskeratosis and frequent mitoses; however, the synchronicity of mitotic figures in early phases of mitosis, as well as the abs...
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Basaloid Follicular Hamartoma: An Additional Criterion of Nevoid Basal Cell Carcinoma Syndrome
Abstract: Basaloid follicular hamartoma (BFH) is a rare, benign follicular neoplasm which typically presents as brown to skin-colored papules on the face, scalp, and trunk. Histologically, BFH consists of cords and strands of basaloid cells forming cystic structures with scant stroma and should be distinguished from infundibulocystic basal cell carcinoma to avoid overly aggressive treatment. Although BFH has been found to be associated with distinct syndromes, including alopecia, myasthenia gravis, and cystic fibrosis, there is often clinical, histopathologic, and genetic overlap with nevoid basal cell carcinoma syndro...
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Primary Cutaneous Gamma-Delta T-Cell Lymphoma Mimicking anaplastic lymphoma kinase-1-Negative Anaplastic Large Cell Lymphoma: A Case Report
Abstract: Primary cutaneous gamma-delta T-cell lymphoma is a rare and aggressive neoplasm, representing less than 1% of all cutaneous T-cell lymphomas. In this article, we report the case of a 49-year-old woman who presented with a history of generalized skin rash and a recent mass on the left upper extremity, as well as right inguinal soft tissue swelling and splenomegaly. Histologic examination of the mass revealed a diffuse subcutaneous infiltrate of large anaplastic and CD30-positive lymphoid cells with rimming of the adipocytes. This case demonstrates unusual cytologic features in primary cutaneous gamma-delta T-c...
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research