Therapeutic improvement of CFTR function and reversibility of bronchiectasis in cystic fibrosis
Eur Respir J. 2024 Mar 28;63(3):2400234. doi: 10.1183/13993003.00234-2024. Print 2024 Mar.NO ABSTRACTPMID:38548272 | DOI:10.1183/13993003.00234-2024 (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Mark O Wielp ütz Marcus A Mall Source Type: research
Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study
This study is registered with ClinicalTrials.gov, number NCT02021292.FINDINGS: Between April 3, 2014, and March 17, 2016, we screened 186 patients for eligibility at 48 hospitals across 20 countries. Of these, 80 patients in 36 hospitals were randomly assigned to treatment (40 patients to macitentan, 40 patients to placebo). At week 16, geometric mean PVR decreased to 71·5% of baseline in the macitentan group and to 87·6% in the placebo group (geometric means ratio 0·81, 95% CI 0·70-0·95, p=0·0098). The most common adverse events in the macitentan group were peripheral oedema (9 [23%] of 40 patients) and decreased ha...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Hossein-Ardeschir Ghofrani G érald Simonneau Andrea M D'Armini Peter Fedullo Luke S Howard Xavier Ja ïs David P Jenkins Zhi-Cheng Jing Michael M Madani Nicolas Martin Eckhard Mayer Kelly Papadakis Dominik Richard Nick H Kim MERIT study investigators Source Type: research
Combined allergic bronchopulmonary mycosis and eosinophilic granulomatosis with polyangiitis: A case report and literature review
Respir Med Case Rep. 2024 Mar 19;48:102012. doi: 10.1016/j.rmcr.2024.102012. eCollection 2024.ABSTRACTA 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases co...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Ning Cui Jingluan Wang Yanmei Shao Jingming Zhao Zhaozhong Cheng Source Type: research
Telehealth Pulmonary Rehabilitation: A Call for Minimum Standards
Am J Respir Crit Care Med. 2024 Mar 27. doi: 10.1164/rccm.202402-0392VP. Online ahead of print.NO ABSTRACTPMID:38536108 | DOI:10.1164/rccm.202402-0392VP (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Surya P Bhatt Richard Casaburi Christopher L Mosher Carolyn L Rochester Chris Garvey Source Type: research
Epidemiology and Prognostic Significance of Cough in Fibrotic Interstitial Lung Disease
Conclusion: Cough is common in patients with IPF and non-IPF fibrotic ILD, with increasing cough severity over time irrespective of ILD-targeted therapy. Patient-reported cough severity has prognostic implications on health-related quality of life, disease progression, and survival in fibrotic ILD.PMID:38536110 | DOI:10.1164/rccm.202311-2101OC (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Yet H Khor Kerri A Johannson Veronica Marcoux Jolene H Fisher Deborah Assayag Helene Manganas Nasreen Khalil Martin Kolb Christopher J Ryerson CARE-PF Investigators Source Type: research
Definitions of Dysbiosis in CLAD and High Bacterial Biomass
Am J Respir Crit Care Med. 2024 Mar 27. doi: 10.1164/rccm.202402-0451ED. Online ahead of print.NO ABSTRACTPMID:38536158 | DOI:10.1164/rccm.202402-0451ED (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: John McGinniss Source Type: research
High-Dimensional Mass Cytometry Reveals Emphysema-associated Changes in the Pulmonary Immune System
CONCLUSION: Using single-cell CyTOF, we characterized the alterations of the immune cell signature in alveolar tissue from patients with COPD stage III/IV emphysema versus control lung tissue. These data contribute to a better understanding of the pathogenesis of emphysema and highlight the feasibility of interrogating the immune cell signature using single-cell and IMC in human lung tissue.PMID:38536165 | DOI:10.1164/rccm.202303-0442OC (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Li Jia Na Li Tamim R M Abdelaal Nannan Guo Marieke E IJsselstein Vincent van Unen Ciska Lindelauf Qinyue Jiang Yanling Xiao M Fernanda Pascutti Pieter S Hiemstra Frits Koning Jan Stolk P Padmini S J Khedoe Source Type: research
Genetically Identifying the "Thrombo-embolic" in CTEPH
Am J Respir Crit Care Med. 2024 Mar 27. doi: 10.1164/rccm.202402-0471ED. Online ahead of print.NO ABSTRACTPMID:38537124 | DOI:10.1164/rccm.202402-0471ED (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Christina A Eichstaedt Source Type: research
Comparison of organ involvement clusters in Black and White American sarcoidosis patients from a prospectively collected patient registry
CONCLUSIONS: The organ clusters of liver-spleen, isolated pulmonary, and musculoskeletal-skin were reproducible in a US cohort, and in both Black and White patients.PMID:38537782 | DOI:10.1016/j.rmed.2024.107605 (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Logan J Harper Anoosha Tauquir Shuaiqi Huang Xiaofeng Wang Jonas C Schupp Robert Baughman Daniel A Culver Source Type: research
The effects of flow settings during high-flow nasal cannula oxygen therapy for neonates and young children
CONCLUSION: Individualising flow settings in neonates and young children requires consideration of the patient's peak inspiratory flow, respiratory rate, heart rate, tolerance, work of breathing and lung aeration for optimal care.PMID:38537946 | DOI:10.1183/16000617.0223-2023 (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Jie Li Ni Deng Wan Jia Aaron He Cui Yang Pan Liu Fai A Albuainain Brian J Ring Andrew G Miller Alexandre T Rotta Robert D Guglielmo Christophe Mil ési Source Type: research
The persistent inflammation in COPD: is autoimmunity the core mechanism?
Eur Respir Rev. 2024 Mar 27;33(171):230137. doi: 10.1183/16000617.0137-2023. Print 2024 Jan 31.ABSTRACTCOPD poses a significant global public health challenge, primarily characterised by irreversible airflow restriction and persistent respiratory symptoms. The hallmark pathology of COPD includes sustained airway inflammation and the eventual destruction of lung tissue structure. While multiple risk factors are implicated in the disease's progression, the underlying mechanisms remain largely elusive. The perpetuation of inflammation is pivotal to the advancement of COPD, emphasising the importance of investigating these sel...
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Ling-Ling Dong Zheng-Yuan Liu Kai-Jun Chen Zhou-Yang Li Jie-Sen Zhou Hua-Hao Shen Zhi-Hua Chen Source Type: research
Central sleep apnoea: not just one phenotype
Eur Respir Rev. 2024 Mar 27;33(171):230141. doi: 10.1183/16000617.0141-2023. Print 2024 Jan 31.ABSTRACTRecent scientific findings in the field of sleep disordered breathing have characterised a variety of phenotypes in obstructive sleep apnoea. These findings have prompted investigations aiming to achieve a more precise differentiation and description of the entities of central sleep apnoea (CSA). There is increasing evidence for the heterogeneity of CSA in terms of underlying aetiology, pathophysiological concepts, treatment response and outcome. Assigning patients to these phenotypes allows for the selection of individua...
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Winfried Randerath S ébastien Baillieul Renaud Tamisier Source Type: research
Albuterol delivery via in-line intrapulmonary percussive ventilation superimposed on conventional mechanical ventilation in an adult lung model
Conclusions: Albuterol delivery via IPV/CMV was modulated by percussion frequency but not increased with increasing VT The delivery efficiency was not sufficiently high for clinical use, in part due to nebulizer retention and extrapulmonary deposition.PMID:38538009 | DOI:10.4187/respcare.11249 (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Takashi Karashima Yuka Mimura-Kimura Yusuke Mimura Source Type: research
The Paradox of Occlusion Pressure at 0.1 s (P < sub > 0.1 < /sub > ) Measurement Without Airway Occlusion
Respir Care. 2024 Mar 27;69(4):524-525. doi: 10.4187/respcare.11813.NO ABSTRACTPMID:38538013 | DOI:10.4187/respcare.11813 (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Giorgio A Iotti Michele Negri Christoph Schranz Source Type: research
Effect of Ventilator Settings on Mechanical Power During Simulated Mechanical Ventilation of Patients With ARDS
CONCLUSIONS: VCV-CF resulted in the lowest MP. VT was the most efficient for maintaining safe and protective MP in a mathematical simulation of subjects with ARDS. In the context of maintaining low and safe MPs, ventilatory strategies with lower-than-normal VT and higher-than-normal breathing frequency will need to be implemented in patients with ARDS.PMID:38538014 | DOI:10.4187/respcare.11470 (Source: Respiratory Care)
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Mohamad F El-Khatib Salah M Zeinelddine Thuraya H HajAli Marwan Rizk Matthias van der Staay Robert L Chatburn Source Type: research
