Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research
Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research
Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies < em > PTPN9 < /em > and < em > SNRPB2 < /em >
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202310-1741LE. Online ahead of print.NO ABSTRACTPMID:38626378 | DOI:10.1164/rccm.202310-1741LE (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Xiaowei Hu John S Kim Aabida Saferali Yong Huang Shwu-Fan Ma Grace C Bingham Catherine A Bonham Carlos Flores Peter Castaldi Craig P Hersh Michael H Cho Imre Noth Ani Manichaikul IPF Survival GWAS Consortium Source Type: research
The Oral-Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease
Semin Respir Crit Care Med. 2024 Apr 16. doi: 10.1055/s-0044-1785673. Online ahead of print.ABSTRACTConnective tissue disease-related interstitial lung disease (CTD-ILD) is a frequent and serious complication of CTD, leading to high morbidity and mortality. Unfortunately, its pathogenesis remains poorly understood; however, one intriguing contributing factor may be the microbiome of the mouth and lungs. The oral microbiome, which is a major source of the lung microbiome through recurrent microaspiration, is altered in ILD patients. Moreover, in recent years, several lines of evidence suggest that changes in the oral and lu...
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Kale S Bongers Angeline Massett David N O'Dwyer Source Type: research
A Tracheostomy Support Device to Reduce Tracheostomy-Related Pressure Injury
CONCLUSIONS: Despite best clinical practice, pressure at the tracheostomy-skin interface can remain quite high. Here we provide measures of this pressure directly and show that a tracheostomy support system can be highly effective at minimizing that pressure. There is room for improvement in tracheostomy care, and such improvement does not have to come at a great expense.PMID:38626951 | DOI:10.4187/respcare.11160 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Andrew M Vahabzadeh-Hagh Luke Lindenmuth Zeyu Feng Jaycee G Custodio Shiv H Patel Source Type: research
Intercostal Muscle Function During Noninvasive Ventilation and Acute Hypercapnic Respiratory Failure
CONCLUSIONS: There is a positive relation between intercostal muscle TF measured by ultrasound and NIV failure, even after adjusting for APACHE II and SOFA scores.PMID:38626952 | DOI:10.4187/respcare.11676 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Mira ç Öz Serhat Erol Fatma Arslan Ayd ın Çiledağ Ak ın Kaya Source Type: research
Pediatric Tracheostomy Year in Review
Respir Care. 2024 Apr 16:respcare.11932. doi: 10.4187/respcare.11932. Online ahead of print.ABSTRACTTracheostomized children have higher mortality compared to adults due to smaller airway anatomy and greater medical complexity and are at high risk for life-threatening complications. Following new tracheostomy placement, caregivers are required to successfully complete extensive training before discharge home. Training for tracheostomy emergencies such as tube obstruction and accidental decannulation is challenging without real-life, hands-on experience, but simulation training has shown promising effects on improving careg...
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: L Denise Willis Source Type: research
Comparative study of imaging and pathology of primary mucinous adenocarcinoma with different imaging manifestations
CONCLUSION: The different imaging manifestations of mucinous adenocarcinoma are possibly due to the different amounts or viscosity of mucus produced, and the mechanisms of its formation may include (1) tumour cells in different shapes have different abilities to produce mucus; (2) tumours in different stages produce different amounts or viscosity of mucus; and (3) the TTF-1 and ALK genes affect the production of mucus.PMID:38616354 | DOI:10.1111/crj.13750 (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Jun Han Jie Gao Demei Chen Mou Du Yuxin Wu Xidong Ma Mei Xie Hua Han Chongchong Wu Xinying Xue Source Type: research
Novel application of nanomedicine for the treatment of acute lung injury: a literature review
Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241244974. doi: 10.1177/17534666241244974.ABSTRACTNanoparticles have attracted extensive attention due to their high degree of cell targeting, biocompatibility, controllable biological activity, and outstanding pharmacokinetics. Changing the size, morphology, and surface chemical groups of nanoparticles can increase the biological distribution of agents to achieve precise tissue targeting and optimize therapeutic effects. Examples of their use include nanoparticles designed for increasing antigen-specific immune responses, developing vaccines, and treating inflammatory diseases....
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Xianfeng Chen Zhanhong Tang Source Type: research
Household Air Pollution Interventions to Improve Health in Low- and Middle-Income Countries: An Official American Thoracic Society Research Statement
Conclusions: HAP is associated with adverse health effects in observational studies. However, it remains unclear which household energy interventions reduce exposure, improve health, can be scaled, and are sustainable. Researchers should engage with policy makers and practitioners working to scale cleaner energy solutions to understand and address their information needs.PMID:38619436 | DOI:10.1164/rccm.202402-0398ST (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Peggy S Lai Nicholas L Lam Bill Gallery Alison G Lee Heather Adair-Rohani Donee Alexander Kalpana Balakrishnan Iwona Bisaga Zoe A Chafe Thomas Clasen Anait é Díaz-Artiga Andrew Grieshop Kat Harrison Stella M Hartinger Darby Jack Seyram Kaali Melissa Lyd Source Type: research
April 15 Highlight
Am J Respir Crit Care Med. 2024 Apr 15;209(8):xxvii-xxx. doi: 10.1164/rccm.209i8xxvii.NO ABSTRACTPMID:38619437 | DOI:10.1164/rccm.209i8xxvii (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Source Type: research
Erratum: A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities
Am J Respir Crit Care Med. 2024 Apr 15;209(8):1045. doi: 10.1164/rccm.v209erratum5.NO ABSTRACTPMID:38619438 | DOI:10.1164/rccm.v209erratum5 (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Source Type: research
Second running title: Prediction of COPD-related exacerbations
CONCLUSIONS: The CEX-HScore was featured by fair accuracy for prediction of COPD-related exacerbations over a 6-month follow-up. Such a tool might therefore support GPs to enhance COPD patients' care, and improve their outcomes by facilitating personalized approaches through a score-based decision support system.PMID:38621547 | DOI:10.1016/j.rmed.2024.107634 (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Francesco Lapi Ettore Marconi Francesco Paolo Lombardo Iacopo Cricelli Elena Ansaldo Marco Gorini Claudio Micheletto Fabiano Di Marco Claudio Cricelli Source Type: research
