Severe Community-Acquired Pneumonia
Semin Respir Crit Care Med. 2024 Apr;45(2):141-142. doi: 10.1055/s-0044-1780515. Epub 2024 Apr 11.NO ABSTRACTPMID:38604187 | DOI:10.1055/s-0044-1780515 (Source: Respiratory Care)
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Ignacio Martin-Loeches Antoni Torres Source Type: research
Severe Community-Acquired Pneumonia: Noninvasive Mechanical Ventilation, Intubation, and HFNT
The objective of all the supporting measures for ARF is to gain time for the antimicrobial treatment to cure the pneumonia. There is uncertainty regarding which patients with severe CAP are most likely to benefit from each noninvasive support strategy. HFNT may be the first-line approach in the majority of patients. While NIV may be relatively contraindicated in patients with excessive secretions, facial hair/structure resulting in air leaks or poor compliance, NIV may be preferable in those with increased work of breathing, respiratory muscle fatigue, and congestive heart failure, in which the positive pressure of NIV may...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Miquel Ferrer Gennaro De Pascale Eloisa S Tanzarella Massimo Antonelli Source Type: research
Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research
A 24-year-Old woman with recurrent pneumothoraces
Respir Med Case Rep. 2024 Mar 27;49:102015. doi: 10.1016/j.rmcr.2024.102015. eCollection 2024.ABSTRACTLymphangioleiomyomatosis (LAM) is an abnormal proliferation of smooth muscle-like cells and may occur sporadically or in association with tuberous sclerosis complex. Patients are typically female, nonsmoking and may have cystic lung disease with pneumothorax. Diagnosis can be made by compatible imaging findings with a history of tuberous sclerosis complex, or in conjunction with vascular endothelial growth factor-D 800 pg/ml or greater, a highly specific finding. Sirolimus is first line treatment for LAM.PMID:38596619 | PM...
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Daniel J Greenberg Anuraag Sah Amit Chopra Nagendra Madisi Source Type: research
Severity of Airflow Obstruction Based on FEV < sub > 1 < /sub > /FVC vs FEV < sub > 1 < /sub > % of Predicted in the General US Population
CONCLUSIONS: FEV1/FVC and FEV1%pred as measures of severity of airflow limitation show similar prediction of breathlessness and mortality in the adult US population across ethnicity groups. However, stage 1 differed more clearly from non-obstructive based on FEV1/FVC than FEV1%pred. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38597717 | DOI:10.1164/rccm.202310-1773OC (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Helena Backman Lowie E G W Vanfleteren David M Mannino Magnus Ekstr öm Source Type: research
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research
NO Casting of NETs in Allergic Asthma
Am J Respir Crit Care Med. 2024 Apr 10. doi: 10.1164/rccm.202403-0599ED. Online ahead of print.NO ABSTRACTPMID:38598776 | DOI:10.1164/rccm.202403-0599ED (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Kyle T Mincham Krish Sanghavi Robert J Snelgrove Source Type: research
Changes in physical activity, sedentary behaviour and sleep following pulmonary rehabilitation: a systematic review and network meta-analysis
CONCLUSION: The addition of physical activity promotion to pulmonary rehabilitation improves volume of physical activity, but not intensity, compared to CBPR. High risk of bias and low certainty of evidence suggests that these results should be viewed with caution.PMID:38599676 | PMC:PMC11004771 | DOI:10.1183/16000617.0225-2023 (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: James Manifield Yousuf Chaudhry Sally J Singh Thomas J C Ward Maxine E Whelan Mark W Orme Source Type: research
Effectiveness of nirmatrelvir-ritonavir versus azvudine for adult inpatients with severe or critical COVID-19
CONCLUSION: Paxlovid and azvudine had similar effectiveness on in-hospital all-cause mortality and hospital length of stay. Compared with the azvudine group, after 7 days of therapy, the degree of decline in SOFA score was significantly higher in the Paxlovid group. These findings need to be verified in larger prospective studies or randomised controlled trials.PMID:38599779 | DOI:10.1136/bmjresp-2023-001944 (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Huan Zhang Tan Xiaojiao Junjun Chen Zheng Zhang Chenxi Wang Haiqing Shi Yao Li Jianbo Li Yan Kang Xiaodong Jin Xuelian Liao Source Type: research
Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis
CONCLUSION: These findings uncover a critical role of ZNF451 in PF progression and introduce a novel regulatory mechanism of ZNF451 in fibroblast activation. Our study suggests that ZNF451 serves as a potential therapeutic target for PF and that strategies aimed at increasing ZNF451 expression may be promising therapeutic approaches for PF.PMID:38600524 | DOI:10.1186/s12931-024-02781-7 (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Hong Peng Yu Zhang Jiali Min Yuexin Tan Shanshan Liu Source Type: research
Public-Private Partnership for TB care and prevention in Korea
Tuberc Respir Dis (Seoul). 2024 Apr 9. doi: 10.4046/trd.2024.0022. Online ahead of print.NO ABSTRACTPMID:38590074 | DOI:10.4046/trd.2024.0022 (Source: Respiratory Care)
Source: Respiratory Care - April 9, 2024 Category: Respiratory Medicine Authors: Jinsoo Min Yoolwon Jeong Source Type: research
Epidemiological Characteristics of Nontuberculous Mycobacterial Pulmonary Disease in South Korea: A Meta-Analysis of Individual Participant Data
CONCLUSION: We performed a meta-analysis of the clinical characteristics of patients with NTM-PD in South Korea. We found age- and sex-related differences in disease-specific severity. Further investigation would enhance our comprehension of the disease's nature and inherited and acquired host factors.PMID:38590075 | DOI:10.4046/trd.2023.0193 (Source: Respiratory Care)
Source: Respiratory Care - April 9, 2024 Category: Respiratory Medicine Authors: Geunin Lee Sol Kim Shihwan Chang Hojoon Sohn Young Ae Kang Youngmok Park Source Type: research
The Analysis of Proteomics by Machine Learning in Separating Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Interstitial Lung Disease
Am J Respir Crit Care Med. 2024 Apr 9. doi: 10.1164/rccm.202403-0603ED. Online ahead of print.NO ABSTRACTPMID:38593003 | DOI:10.1164/rccm.202403-0603ED (Source: Respiratory Care)
Source: Respiratory Care - April 9, 2024 Category: Respiratory Medicine Authors: Yuben Moodley Source Type: research
Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin
Am J Respir Cell Mol Biol. 2024 Apr 9. doi: 10.1165/rcmb.2023-0294MA. Online ahead of print.ABSTRACTInvestigations into the mechanisms of injury and repair in fibroproliferative disease require consideration of the spatial heterogeneity inherent in the disease. Most scoring of fibrotic remodeling in preclinical animal models rely on the modified Ashcroft score, which is a semi-quantitative scoring rubric of macroscopic resolution. The obvious limitations inherent in manual pathohistological grading have generated an unmet need for unbiased, repeatable scoring of fibroproliferative burden in tissue. Using computer vision ap...
Source: Respiratory Care - April 9, 2024 Category: Respiratory Medicine Authors: Brendan P Cox Riley T Hannan Noora Batrash Pearl Raichura Anne I Sperling Yun Michael Shim Jeffrey M Sturek Source Type: research
Why Is BMI Related to COPD? Is It All in the Genes?
Am J Respir Crit Care Med. 2024 Apr 9. doi: 10.1164/rccm.202403-0601ED. Online ahead of print.NO ABSTRACTPMID:38593419 | DOI:10.1164/rccm.202403-0601ED (Source: Respiratory Care)
Source: Respiratory Care - April 9, 2024 Category: Respiratory Medicine Authors: Ana I Hern ández Cordero Don D Sin Source Type: research
