Investigation of predictors for in-hospital death or long-term hospitalization in community-acquired pneumonia with risk factors for aspiration
CONCLUSIONS: Blood sampling findings and bedridden status are useful for predicting in-hospital mortality and long-term hospitalization in patients with pneumonia and any risk factor for aspiration.PMID:38586609 | PMC:PMC10997353 | DOI:10.1080/20018525.2024.2335721 (Source: Respiratory Care)
Source: Respiratory Care - April 8, 2024 Category: Respiratory Medicine Authors: Issei Oi Isao Ito Naoya Tanabe Satoshi Konishi Yumiko Ibi Yu Hidaka Nobuyoshi Hamao Masahiro Shirata Kensuke Nishioka Seiichiro Imai Yoshiro Yasutomo Seizo Kadowaki Toyohiro Hirai Source Type: research
DACH1 Attenuates Airway Inflammation in COPD by Activating NRF2 Signaling
This study aims to elucidate the role and underlying mechanism of DACH1 in airway inflammation of COPD. DACH1 expression was measured in lung tissues of patients with COPD. Airway epithelium-specific DACH1 knockdown mice and AAV-transfected DACH1 overexpressed mice were used to investigate its role and potential for therapeutic targeting in experimental COPD caused by CS. Furthermore, we discovered a potential mechanism of DACH1 in inflammation induced by cigarette smoke extract simulation (CSE) in vitro. Compared to non-smokers and smokers without COPD, COPD patients had reduced DACH1 expression, especially in the airway ...
Source: Respiratory Care - April 8, 2024 Category: Respiratory Medicine Authors: Qian Huang Yiya Gu Jixing Wu Yuan Zhan Zhesong Deng Shanshan Chen Maocuo Peng Ruonan Yang Jinkun Chen Jungang Xie Source Type: research
Unique presentation of an endemic opportunistic fungal infection: Disseminated coccidioidomycosis mimicking metastatic lung cancer with endotracheal and endobronchial involvement
This report describes an unusual presentation of disseminated Coccidioidomycosis in an immunocompetent individual. The patient was admitted with a subacute cough, progressively worsening shortness of breath, significant weight loss, nodular skin lesions in upper extremities, and acute hypoxemic respiratory failure. Chest imaging revealed extensive nodularity and mass-like lesions. What sets this case apart is the significant endotracheal and endobronchial involvement, which mimicked metastatic lung cancer. The diagnosis was confirmed through serology and bronchoscopy biopsy. This case underscores the critical importance of...
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Amir R Reihani Naveen Jayakumar Ricardo Searcy Anderson N Vu Anil Perumbeti Justin Thomas Source Type: research
Reexamining COPD in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria
Am J Respir Crit Care Med. 2024 Apr 5. doi: 10.1164/rccm.202402-0289LE. Online ahead of print.NO ABSTRACTPMID:38579279 | DOI:10.1164/rccm.202402-0289LE (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Yen-Fu Chen Jung-Yien Chien Hao-Chien Wang Chong-Jen Yu Source Type: research
Reply to Chen et al.: Reexamining COPD in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria
Am J Respir Crit Care Med. 2024 Apr 5. doi: 10.1164/rccm.202403-0476LE. Online ahead of print.NO ABSTRACTPMID:38579281 | DOI:10.1164/rccm.202403-0476LE (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: James D Chalmers Anthony De Soyza Stefano Aliberti Eva Polverino Source Type: research
Whole-course management of chronic obstructive pulmonary disease in primary healthcare: an internet of things-enabled prospective cohort study in China
CONCLUSION: Strategy based on IoT model help improve the detection rate of COPD in PHC. This cohort study has established a large clinical database that encompasses a wide range of demographic and relevant data of COPD and will provide invaluable resources for future research.PMID:38580439 | DOI:10.1136/bmjresp-2023-001954 (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Xingru Zhao Haonan Kang Yunxia An Zhiwei Xu Meihui Wei Quncheng Zhang Linqi Diao Zhiping Guo Xiaoju Zhang Source Type: research
Unveiling the truth: is COVID-19 reimbursement in Colombia a flawed design? A cost-of-illness analysis for moderate, severe and critical infections
CONCLUSION: Our study underscores the inadequacies of the previous reimbursement system in addressing the varying resource utilisation and costs associated with COVID-19 inpatient care. Our analysis reveals substantial discrepancies between estimated costs and actual resource utilisation, particularly for severe and critical cases. We advocate for government flexibility in revising reimbursement baskets, supported by pilot studies to assess effectiveness. The use of real-world evidence forms a crucial basis for informed adjustments to reimbursement levels in preparation for future pandemics. This proactive approach ensures...
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Liliana Fernandez-Trujillo Saveria Sangiovanni Ana Isabel Castrillon Lina Hincapie-Zapata Lina Maria G óez-Mogollón Marcela Brun Vergara Sergio I Prada Source Type: research
Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy
CONCLUSIONS: This study shows that MCTS are interesting models to study the impact of first line therapies using conditions close to clinical practice and also to identify more adapted second line or concomitant therapies for lung cancer treatment.PMID:38581044 | PMC:PMC10998296 | DOI:10.1186/s12931-024-02791-5 (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Pauline Hulo Sophie Deshayes Judith Fresquet Anne-Laure Ch éné St éphanie Blandin Nicolas Boisgerault Jean-Fran çois Fonteneau Lucas Treps Marc G Denis Jaafar Bennouna Delphine Fradin Elvire Pons-Tostivint Christophe Blanquart Source Type: research
Unique presentation of an endemic opportunistic fungal infection: Disseminated coccidioidomycosis mimicking metastatic lung cancer with endotracheal and endobronchial involvement
This report describes an unusual presentation of disseminated Coccidioidomycosis in an immunocompetent individual. The patient was admitted with a subacute cough, progressively worsening shortness of breath, significant weight loss, nodular skin lesions in upper extremities, and acute hypoxemic respiratory failure. Chest imaging revealed extensive nodularity and mass-like lesions. What sets this case apart is the significant endotracheal and endobronchial involvement, which mimicked metastatic lung cancer. The diagnosis was confirmed through serology and bronchoscopy biopsy. This case underscores the critical importance of...
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Amir R Reihani Naveen Jayakumar Ricardo Searcy Anderson N Vu Anil Perumbeti Justin Thomas Source Type: research
Reexamining COPD in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria
Am J Respir Crit Care Med. 2024 Apr 5. doi: 10.1164/rccm.202402-0289LE. Online ahead of print.NO ABSTRACTPMID:38579279 | DOI:10.1164/rccm.202402-0289LE (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Yen-Fu Chen Jung-Yien Chien Hao-Chien Wang Chong-Jen Yu Source Type: research
Reply to Chen et al.: Reexamining COPD in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria
Am J Respir Crit Care Med. 2024 Apr 5. doi: 10.1164/rccm.202403-0476LE. Online ahead of print.NO ABSTRACTPMID:38579281 | DOI:10.1164/rccm.202403-0476LE (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: James D Chalmers Anthony De Soyza Stefano Aliberti Eva Polverino Source Type: research
Whole-course management of chronic obstructive pulmonary disease in primary healthcare: an internet of things-enabled prospective cohort study in China
CONCLUSION: Strategy based on IoT model help improve the detection rate of COPD in PHC. This cohort study has established a large clinical database that encompasses a wide range of demographic and relevant data of COPD and will provide invaluable resources for future research.PMID:38580439 | DOI:10.1136/bmjresp-2023-001954 (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Xingru Zhao Haonan Kang Yunxia An Zhiwei Xu Meihui Wei Quncheng Zhang Linqi Diao Zhiping Guo Xiaoju Zhang Source Type: research
Unveiling the truth: is COVID-19 reimbursement in Colombia a flawed design? A cost-of-illness analysis for moderate, severe and critical infections
CONCLUSION: Our study underscores the inadequacies of the previous reimbursement system in addressing the varying resource utilisation and costs associated with COVID-19 inpatient care. Our analysis reveals substantial discrepancies between estimated costs and actual resource utilisation, particularly for severe and critical cases. We advocate for government flexibility in revising reimbursement baskets, supported by pilot studies to assess effectiveness. The use of real-world evidence forms a crucial basis for informed adjustments to reimbursement levels in preparation for future pandemics. This proactive approach ensures...
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Liliana Fernandez-Trujillo Saveria Sangiovanni Ana Isabel Castrillon Lina Hincapie-Zapata Lina Maria G óez-Mogollón Marcela Brun Vergara Sergio I Prada Source Type: research
Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy
CONCLUSIONS: This study shows that MCTS are interesting models to study the impact of first line therapies using conditions close to clinical practice and also to identify more adapted second line or concomitant therapies for lung cancer treatment.PMID:38581044 | DOI:10.1186/s12931-024-02791-5 (Source: Respiratory Care)
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Pauline Hulo Sophie Deshayes Judith Fresquet Anne-Laure Ch éné St éphanie Blandin Nicolas Boisgerault Jean-Fran çois Fonteneau Lucas Treps Marc G Denis Jaafar Bennouna Delphine Fradin Elvire Pons-Tostivint Christophe Blanquart Source Type: research
Unique presentation of an endemic opportunistic fungal infection: Disseminated coccidioidomycosis mimicking metastatic lung cancer with endotracheal and endobronchial involvement
This report describes an unusual presentation of disseminated Coccidioidomycosis in an immunocompetent individual. The patient was admitted with a subacute cough, progressively worsening shortness of breath, significant weight loss, nodular skin lesions in upper extremities, and acute hypoxemic respiratory failure. Chest imaging revealed extensive nodularity and mass-like lesions. What sets this case apart is the significant endotracheal and endobronchial involvement, which mimicked metastatic lung cancer. The diagnosis was confirmed through serology and bronchoscopy biopsy. This case underscores the critical importance of...
Source: Respiratory Care - April 5, 2024 Category: Respiratory Medicine Authors: Amir R Reihani Naveen Jayakumar Ricardo Searcy Anderson N Vu Anil Perumbeti Justin Thomas Source Type: research
