Vitamin A and bronchopulmonary dysplasia: the next steps
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00108-5. doi: 10.1016/S2213-2600(24)00108-5. Online ahead of print.NO ABSTRACTPMID:38643781 | DOI:10.1016/S2213-2600(24)00108-5 (Source: Respiratory Care)
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Abhijeet Rakshasbhuvankar J Jane Pillow Source Type: research
Optimizing Clinical Outcomes for Bronchoscopic Lung Volume Reduction with Zephyr ® Valves
Respir Med. 2024 Apr 18:107639. doi: 10.1016/j.rmed.2024.107639. Online ahead of print.ABSTRACTBronchoscopic lung volume reduction treatment with Zephyr one-way valves is an effective guideline-based treatment option for patients with severe emphysema and hyperinflation. However, in some cases the treatment response is less than anticipated or there might be a loss of initial treatment effect. Reasons for the lack of response can include incorrect assessment of collateral ventilation, improper valve placement, or patient related factors. Loss of initial benefit can be due to granulation tissue formation and subsequent valv...
Source: Respiratory Care - April 20, 2024 Category: Respiratory Medicine Authors: T David Koster Pallav L Shah Arschang Valipour Gerard J Criner Felix J F Herth Richard Sue Douglas K Hogarth Ralitza T Martin Amit K Mahajan Raed Alalawi Lisa Kopas Avi Cohen Douglas E Wood Jonathan Kurman Narinder S Shargill Mark Dransfield Dirk-Jan Sleb Source Type: research
A historical cohort study on predictors for successful weaning from prolonged mechanical ventilation and up to 3-year survival follow-up in a rehabilitation center
CONCLUSION: Successful weaning from PMV may be associated with better survival and allows chronically ventilated patients to become independent on a ventilator. A larger study is needed to further validate our findings.PMID:38642907 | DOI:10.1016/j.rmed.2024.107636 (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2024 Category: Respiratory Medicine Authors: Mila Fradkin Maya Elyashiv Amasha Camel Nirit Agay Michael Brik Pierre Singer Rachel Dankner Source Type: research
Suboptimal peak inspiratory flow rate: a noticeable risk factor for inhaler concordance in patients with chronic airway diseases
CONCLUSION: Inhaler concordance was low, and suboptimal PIFR was a risk factor for poor concordance among Chinese patients with chronic airway diseases. In addition, current inhalation devices may not be suitable, and PIFR reassessment should be considered for patients with COPD during exacerbation.TRIAL REGISTRATION NUMBER: The study was registered in chictr.org.cn (ChiCTR2100052527) on 31 October 2021.PMID:38642917 | PMC:PMC11033634 | DOI:10.1136/bmjresp-2023-001981 (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2024 Category: Respiratory Medicine Authors: Weiwei Meng Ruoyan Xiong Zhiqi Zhao Huihui Zeng Yan Chen Source Type: research
Bacterial interactome disturbance in chronic obstructive pulmonary disease clinical stability and exacerbations
CONCLUSIONS: Bacterial interactome disturbance characterized by reduced antagonistic interactions, rather than change in pathogen abundance or diversity, is a reproducible feature of airway dysbiosis in COPD clinical stability and exacerbations, which suggests that we may target interactome rather than pathogen alone for disease treatment.PMID:38643126 | PMC:PMC11032604 | DOI:10.1186/s12931-024-02802-5 (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2024 Category: Respiratory Medicine Authors: Wei Xiao Yi-Long Chen Long-Yi Du Jiqiu Wu Zhang Wang Bing Mao Fu-Qiang Wen Peter Gerard Gibson Vanessa M McDonald Haopeng Yu Juan-Juan Fu Source Type: research
PPAR γ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap
CONCLUSION: The findings suggest that senescence in macrophages, particularly alveolar macrophages, plays a crucial role in the pathophysiology of ACO. Furthermore, PPARγ may represent a potential therapeutic target for interventions aimed at modulating senescence-associated processes in ACO.Key words ACO, Asthma, COPD, Macrophages, Senescence, PPARγ.PMID:38643159 | PMC:PMC11032609 | DOI:10.1186/s12931-024-02790-6 (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2024 Category: Respiratory Medicine Authors: Rongjun Wan Prakhyath Srikaram Shaobing Xie Qiong Chen Chengping Hu Mei Wan Yuanyuan Li Peisong Gao Source Type: research
Longitudinal changes in lung function following post-9/11 military deployment in symptomatic veterans
CONCLUSIONS: More intense inhalational exposures were linked with lower post-deployment lung function. Those with distal lung disease (DDLD) experienced significant longitudinal decline in FEV1/FVC ratio, but other DRRD diagnosis groups did not.PMID:38641121 | DOI:10.1016/j.rmed.2024.107638 (Source: Respiratory Care)
Source: Respiratory Care - April 19, 2024 Category: Respiratory Medicine Authors: Lauren M Zell-Baran Silpa Krefft Matthew Strand Cecile S Rose Source Type: research
AB(2)CO risk score for in-hospital mortality of COVID-19 patients admitted to intensive care units
CONCLUSIONS: The AB2CO score is a fast and easy tool to be used upon ICU admission.PMID:38641122 | DOI:10.1016/j.rmed.2024.107635 (Source: Respiratory Care)
Source: Respiratory Care - April 19, 2024 Category: Respiratory Medicine Authors: Virginia Mara Reis Gomes Magda Carvalho Pires Polianna Delfino Pereira Alexandre Vargas Schwarzbold Ang élica Gomides Dos Reis Gomes Bruno Porto Pessoa Christiane Correa Rodrigues Cimini Danyelle Romana Alves Rios Fernando Anschau Francine Jana ína Maga Source Type: research
Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic, Omalizumab, in Severe Asthma in Adults: Results of the SoMOSA Study
Conclusions This is the first discovery of omics biomarkers that predict improvement to a biologic for asthma. Their prospective validation and development for clinical use is justified.PMID:38635834 | DOI:10.1164/rccm.202310-1730OC (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Ratko Djukanovi ć Paul Brinkman Johan Kolmert Cristina Gomez James Schofield Joost Brandsma Andy Shapanis Paul J S Skipp Anthony Postle Craig Wheelock Sven-Erik Dahlen Peter J Sterk Thomas Brown David J Jackson Adel Mansur Ian Pavord Mitesh Patel Christo Source Type: research
Asthma Pathogenesis: Phenotypes, Therapies and Gaps. Summary of the Aspen Lung Conference 2023
This report summarizes the proceedings of the 2023 Aspen Lung Conference, which was organized to review the clinical and molecular heterogeneity of asthma and to better understand the impact of genetic, environmental, cellular, and molecular influences on disease susceptibility, heterogeneity, and severity. The goals of the conference were to review new information about asthma phenotypes, cellular processes, and cellular signatures underlying disease heterogeneity and treatment response. The report concludes with ongoing gaps in our understanding of asthma pathobiology and provides some recommendations for future research...
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Sunita Sharma Anthony N Gerber Monica Kraft Sally E Wenzel Source Type: research
Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research
Asthma patients' and physicians' perspectives on the burden and management of asthma: post-hoc analysis of APPaRENT 1 and 2 to assess predictors of treatment adherence
CONCLUSIONS: Results revealed an important disconnect between patient and physician treatment goals and treatment adherence, suggesting that strategies for improving patient adherence to maintenance medication are needed, focusing on younger patients with milder disease. High reliever use despite good adherence may indicate poor disease control. Personalised care considering patient characteristics alongside physician training in motivational communication and shared decision-making could improve patient management and outcomes.PMID:38636683 | DOI:10.1016/j.rmed.2024.107637 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Giorgio Walter Canonica Christian Domingo Kim L Lavoie Amrit Kaliasethi Shireen Quli Khan Anurita Majumdar Sourabh Fulmali Source Type: research
Sputum colour as a simplified effective biomarker for clinical assessment of bronchiectasis
Eur Respir J. 2024 Apr 18;63(4):2400152. doi: 10.1183/13993003.00152-2024. Print 2024 Apr.NO ABSTRACTPMID:38636972 | DOI:10.1183/13993003.00152-2024 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Rui-di Tang Jun-Qing Yue Wei-Jie Guan Source Type: research
The association of blood eosinophil counts and FEV < sub > 1 < /sub > decline: a cohort study
CONCLUSIONS: Blood eosinophil counts were associated with a faster lung function decline among healthy individuals without lung disease, independent of smoking status. The findings suggest that blood eosinophil counts contribute to the risk of faster lung function decline, particularly among younger adults without a history of lung disease.PMID:38636990 | DOI:10.1183/13993003.01037-2023 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Yun Soo Hong Hye Yun Park Seungho Ryu Sun Hye Shin Di Zhao Dave Singh Eliseo Guallar Juhee Cho Yoosoo Chang Seong Yong Lim Source Type: research
Rate of severe exacerbations, healthcare resource utilisation and clinical outcomes in patients with COPD in low-income and middle-income countries: results from the EXACOS International Study
DISCUSSION: The findings presented here indicate that effective treatment strategies to prevent severe exacerbations in patients with COPD remain a significant unmet need in low-income and middle-income countries.PMID:38637115 | PMC:PMC11029392 | DOI:10.1136/bmjresp-2023-002101 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Rodrigo Abensur Athanazio Laura Bernal Villada Sergey N Avdeev Hao-Chien Wang Alejandra Ram írez-Venegas Mart ín Sivori Jorge Dreyse Manuel Pacheco Sin Kit Man Lorena Noriega-Aguirre Hisham Farouk Source Type: research
