Non-invasive ventilation in acute respiratory failure of oncology-hematology patients: What are its current benefits and limitations?
Rev Mal Respir. 2024 Apr 11:S0761-8425(24)00171-2. doi: 10.1016/j.rmr.2024.03.005. Online ahead of print.ABSTRACTAcute respiratory failure (ARF) is a leading cause, along with sepsis, of admission to the intensive care unit (ICU) of patients with active cancer. Presenting variable clinical severity, ARF in onco-hematological patients has differing etiologies, primarily represented by possibly opportunistic acute infectious pneumonia (de novo hypoxemic ARF), and decompensation in chronic cardiac or respiratory diseases (e.g., acute pulmonary edema or exacerbated chronic obstructive pulmonary disease). In these patients, oro...
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: J Mayaux M Decavele M Dres M Lecronier A Demoule Source Type: research

Take-home messages from the 2nd COPD 2023 Biennial of the French Society of Respiratory Diseases. Placing the patient at the center of the care pathway
CONCLUSIONS: As regards COPD, a personalized approach is crucial, placing the patient at the center of the care pathway and facilitating coordination between healthcare providers.PMID:38609767 | DOI:10.1016/j.rmr.2024.03.008 (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: J Ancel E Chen A Pavot L Regard O Le Rouzic M Guecamburu M Zysman A Rapin C Martin T Soumagne M Patout N Roche G Deslee Source Type: research

Prevalence and risk factors of depression in patients with chronic obstructive airway disease: a tertiary care hospital, outpatient setting
CONCLUSION: The prevalence of depression in patients with COPD in a tertiary care outpatient setting was low, at 4%. According to the study's comprehensive assessment, severity of COPD was the only factor associated with depression in patients with COPD.PMID:38606670 | DOI:10.5826/mrm.2024.951 (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: Seksan Chaisuksant Panupong Suwannatat Kittisak Sawanyawisuth Source Type: research

Independent effect of the triglyceride-glucose index on all-cause mortality in critically ill patients with chronic obstructive pulmonary disease and asthma: A retrospective cohort study
CONCLUSIONS: In summary, our results extend the utility of the TyG index to critically ill patients with COPD and asthma. Our study shows that the TyG index is a potential predictor of all-cause mortality in critically ill patients with COPD and asthma. In addition, in patients with a TyG index exceeding 4.8, there was a heightened risk of mortality. Measuring the TyG index may help with risk stratification and prognosis prediction in critically ill patients with COPD and asthma. Further prospective studies are needed to confirm our findings.PMID:38607315 | DOI:10.1177/14799731241245424 (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: Wen-Qiang Zhou Xin Song Wei-Hua Dong Zhi Chen Source Type: research

Application of the ERS/ATS Spirometry Standards and Race-Neutral Equations in the COPDGene Study
CONCLUSIONS: The zGLI Global severity classification outperformed GOLD in the discrimination of survival, exacerbations, and imaging characteristics.PMID:38607551 | DOI:10.1164/rccm.202311-2145OC (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: Enrico Schiavi Min Hyung Ryu Leonardo Martini Aparna Balasubramanian Meredith C McCormack Spyridon Fortis Elizabeth A Regan Matteo Bonini Craig P Hersh Source Type: research

Reply to Tiruvoipati < em > et al. < /em > : VENT-AVOID Trial - Avoiding Acute Hypercapnic Respiratory Failure!
Am J Respir Crit Care Med. 2024 Apr 12. doi: 10.1164/rccm.202403-0618LE. Online ahead of print.NO ABSTRACTPMID:38608271 | DOI:10.1164/rccm.202403-0618LE (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: Abhijit Duggal Steven A Conrad Laurent Brochard Daniel Brodie Nicholas S Hill Source Type: research

VENT-AVOID Trial - Avoiding Acute Hypercapnic Respiratory Failure!
Am J Respir Crit Care Med. 2024 Apr 12. doi: 10.1164/rccm.202403-0514LE. Online ahead of print.NO ABSTRACTPMID:38608272 | DOI:10.1164/rccm.202403-0514LE (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: Ravindranath Tiruvoipati Sameer Kaul Sachin Gupta Kavi Haji Source Type: research

Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research

Fine-Scale Neighborhood Air Pollution Mapping: A First Step Towards Decoding Racial Asthma Disparities
Am J Respir Crit Care Med. 2024 Apr 11. doi: 10.1164/rccm.202403-0591ED. Online ahead of print.NO ABSTRACTPMID:38602863 | DOI:10.1164/rccm.202403-0591ED (Source: Respiratory Care)
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Neeta Thakur John R Balmes Source Type: research

Severe Community-Acquired Pneumonia
Semin Respir Crit Care Med. 2024 Apr;45(2):141-142. doi: 10.1055/s-0044-1780515. Epub 2024 Apr 11.NO ABSTRACTPMID:38604187 | DOI:10.1055/s-0044-1780515 (Source: Respiratory Care)
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Ignacio Martin-Loeches Antoni Torres Source Type: research

Severe Community-Acquired Pneumonia: Noninvasive Mechanical Ventilation, Intubation, and HFNT
The objective of all the supporting measures for ARF is to gain time for the antimicrobial treatment to cure the pneumonia. There is uncertainty regarding which patients with severe CAP are most likely to benefit from each noninvasive support strategy. HFNT may be the first-line approach in the majority of patients. While NIV may be relatively contraindicated in patients with excessive secretions, facial hair/structure resulting in air leaks or poor compliance, NIV may be preferable in those with increased work of breathing, respiratory muscle fatigue, and congestive heart failure, in which the positive pressure of NIV may...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Miquel Ferrer Gennaro De Pascale Eloisa S Tanzarella Massimo Antonelli Source Type: research

Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research

A 24-year-Old woman with recurrent pneumothoraces
Respir Med Case Rep. 2024 Mar 27;49:102015. doi: 10.1016/j.rmcr.2024.102015. eCollection 2024.ABSTRACTLymphangioleiomyomatosis (LAM) is an abnormal proliferation of smooth muscle-like cells and may occur sporadically or in association with tuberous sclerosis complex. Patients are typically female, nonsmoking and may have cystic lung disease with pneumothorax. Diagnosis can be made by compatible imaging findings with a history of tuberous sclerosis complex, or in conjunction with vascular endothelial growth factor-D 800 pg/ml or greater, a highly specific finding. Sirolimus is first line treatment for LAM.PMID:38596619 | PM...
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Daniel J Greenberg Anuraag Sah Amit Chopra Nagendra Madisi Source Type: research

Severity of Airflow Obstruction Based on FEV < sub > 1 < /sub > /FVC vs FEV < sub > 1 < /sub > % of Predicted in the General US Population
CONCLUSIONS: FEV1/FVC and FEV1%pred as measures of severity of airflow limitation show similar prediction of breathlessness and mortality in the adult US population across ethnicity groups. However, stage 1 differed more clearly from non-obstructive based on FEV1/FVC than FEV1%pred. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38597717 | DOI:10.1164/rccm.202310-1773OC (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Helena Backman Lowie E G W Vanfleteren David M Mannino Magnus Ekstr öm Source Type: research

Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research