Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study
This study is registered with ClinicalTrials.gov, number NCT02021292.FINDINGS: Between April 3, 2014, and March 17, 2016, we screened 186 patients for eligibility at 48 hospitals across 20 countries. Of these, 80 patients in 36 hospitals were randomly assigned to treatment (40 patients to macitentan, 40 patients to placebo). At week 16, geometric mean PVR decreased to 71·5% of baseline in the macitentan group and to 87·6% in the placebo group (geometric means ratio 0·81, 95% CI 0·70-0·95, p=0·0098). The most common adverse events in the macitentan group were peripheral oedema (9 [23%] of 40 patients) and decreased ha...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Hossein-Ardeschir Ghofrani G érald Simonneau Andrea M D'Armini Peter Fedullo Luke S Howard Xavier Ja ïs David P Jenkins Zhi-Cheng Jing Michael M Madani Nicolas Martin Eckhard Mayer Kelly Papadakis Dominik Richard Nick H Kim MERIT study investigators Source Type: research
Combined allergic bronchopulmonary mycosis and eosinophilic granulomatosis with polyangiitis: A case report and literature review
Respir Med Case Rep. 2024 Mar 19;48:102012. doi: 10.1016/j.rmcr.2024.102012. eCollection 2024.ABSTRACTA 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases co...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Ning Cui Jingluan Wang Yanmei Shao Jingming Zhao Zhaozhong Cheng Source Type: research
The impact on thirty day readmissions for patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease admitted to an observation unit versus an inpatient medical unit: A retrospective observational study
CONCLUSION: Patients admitted for AECOPD with a history of PE, CHF, prior AECOPD admissions, and socioeconomic deprivation are at higher risk of readmission and should be prioritized for direct inpatient admission. Further prospective studies should be conducted to determine the clinical impact of this approach on readmission rates.PMID:38545901 | DOI:10.1177/14799731241242490 (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Jacob Bell Steven Lim Takahisa Mikami Jeeyune Bahk Stephen Argiro David Steiger Source Type: research
Alveolar Collapse as a Threat to Mechanically Ventilated Lungs
Am J Respir Crit Care Med. 2024 Mar 28. doi: 10.1164/rccm.202402-0326ED. Online ahead of print.NO ABSTRACTPMID:38546274 | DOI:10.1164/rccm.202402-0326ED (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Elena Spinelli Tommaso Mauri Source Type: research
Significant Airway Obstruction by Carbonaceous Fibrin Casts in a Child with Smoke Inhalation Injury
Am J Respir Crit Care Med. 2024 Mar 28. doi: 10.1164/rccm.202212-2289IM. Online ahead of print.NO ABSTRACTPMID:38546283 | DOI:10.1164/rccm.202212-2289IM (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Annemarie G Wolfe Paul C Stillwell Livia A Veress Source Type: research
Application of Metabolomics Across the Spectrum of Pulmonary and Critical Care Medicine
We present several examples of metabolomics applied to pulmonary and critical care medicine in order to illustrate the potential of this avenue of research to deepen our understanding of pathophysiology. We conclude by reviewing recent advances in the field and future research directions that stand to further the goal of personalizing medicine in order to improve patient care.PMID:38547373 | DOI:10.1165/rcmb.2024-0080PS (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Catherine E Simpson Julie G Ledford Gang Liu Source Type: research
Contemporary Strategies: Incorporating Immunotherapy into Stage III Non-Small Cell Lung Cancer Treatment
Tuberc Respir Dis (Seoul). 2024 Mar 28. doi: 10.4046/trd.2023.0162. Online ahead of print.ABSTRACTStage III non-small cell lung cancer (NSCLC) exhibits significant diversity, making it challenging to define an optimal treatment. A collaborative multidisciplinary approach is essential in crafting individualized treatments. Previously, targeted therapies and immunotherapies were commonly used to treat patients with advanced and metastatic lung cancer. Such treatments are now being extended to individuals considered surgery, as well as patients once considered unsuitable for surgery. These changes have increased surgical succ...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Da Hyun Kang Chaeuk Chung Source Type: research
Systemic Lupus Erythematosus-related Lung Disease
Semin Respir Crit Care Med. 2024 Mar 28. doi: 10.1055/s-0044-1782653. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) is a multifaceted, multisystem autoimmune disorder with diverse clinical expressions. While prevalence reports vary widely, pulmonary involvement accounts for significant morbidity and mortality in SLE. This comprehensive review explores the spectrum of pulmonary disease in SLE, including upper airway manifestations (e.g., laryngeal affection), lower airway conditions (e.g., bronchitis, bronchiolitis, bronchiectasis), parenchymal diseases (e.g., interstitial lung disease, acute lupus pneumo...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Elisabeth Bendstrup Evelyn Lynn Anne Troldborg Source Type: research
Approach to Pulmonary Nodules in Connective Tissue Disease
Semin Respir Crit Care Med. 2024 Mar 28. doi: 10.1055/s-0044-1782656. Online ahead of print.ABSTRACTThe assessment of pulmonary nodules is a common and often challenging clinical scenario. This evaluation becomes even more complex in patients with connective tissue diseases (CTDs), as a range of disease-related factors must also be taken into account. These diseases are characterized by immune-mediated chronic inflammation, leading to tissue damage, collagen deposition, and subsequent organ dysfunction. A thorough examination of nodule features in these patients is required, incorporating anatomic and functional informatio...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Brian Gaffney David J Murphy Source Type: research
Pleural Diseases in Connective Tissue Diseases
Semin Respir Crit Care Med. 2024 Mar 28. doi: 10.1055/s-0044-1782612. Online ahead of print.ABSTRACTConnective tissue diseases (CTD) are heterogeneous, immune-mediated inflammatory disorders often presenting with multiorgan involvement. With the advent of high-resolution computed tomography, CTD-related pleuritis-pleural thickening and effusion-is now increasingly recognized early in the disease trajectory. The natural history of CTD-related pleural effusions varies from spontaneous resolution to progressive fibrothorax with ventilatory impairment. Treatment of the underlying CTD is necessary to manage the pleural disease....
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Hui Guo Beenish Iqbal Najib M Rahman Source Type: research
Latent class analysis of chest CT abnormalities to define subphenotypes in patients with MPO-ANCA-positive microscopic polyangiitis
CONCLUSIONS: These findings suggest that bronchiectasis may represent a unique pattern of pulmonary involvement in MPO-MPA, highlighting the importance of screening for bronchiectasis in MPO-MPA and identifying optimal management strategies.PMID:38548141 | DOI:10.1016/j.rmed.2024.107613 (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Yu Gu Ting Zhang Min Peng Yang Han Weihong Zhang Juhong Shi Source Type: research
A comprehensive evaluation of online inhaler use techniques for obstructive airway disease
CONCLUSIONS: This study highlights gaps in online resources describing inhaler technique, particularly related to preparation/first use and post-usage/device care steps. Clinically relevant factors were rarely addressed across websites. Improvements in these areas could lead to enhanced inhaler technique and clinical outcomes.PMID:38548142 | DOI:10.1016/j.rmed.2024.107607 (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Brandon Luu Anu Chinnadurai Omer Choudhary Nikki Breede Lee Fidler Clodagh Ryan Hashim Khan Ambrose Lau Alina Blazer Kirsten Wentlandt Dmitry Rozenberg Source Type: research
Therapeutic improvement of CFTR function and reversibility of bronchiectasis in cystic fibrosis
Eur Respir J. 2024 Mar 28;63(3):2400234. doi: 10.1183/13993003.00234-2024. Print 2024 Mar.NO ABSTRACTPMID:38548272 | DOI:10.1183/13993003.00234-2024 (Source: Respiratory Care)
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Mark O Wielp ütz Marcus A Mall Source Type: research
Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study
This study is registered with ClinicalTrials.gov, number NCT02021292.FINDINGS: Between April 3, 2014, and March 17, 2016, we screened 186 patients for eligibility at 48 hospitals across 20 countries. Of these, 80 patients in 36 hospitals were randomly assigned to treatment (40 patients to macitentan, 40 patients to placebo). At week 16, geometric mean PVR decreased to 71·5% of baseline in the macitentan group and to 87·6% in the placebo group (geometric means ratio 0·81, 95% CI 0·70-0·95, p=0·0098). The most common adverse events in the macitentan group were peripheral oedema (9 [23%] of 40 patients) and decreased ha...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Hossein-Ardeschir Ghofrani G érald Simonneau Andrea M D'Armini Peter Fedullo Luke S Howard Xavier Ja ïs David P Jenkins Zhi-Cheng Jing Michael M Madani Nicolas Martin Eckhard Mayer Kelly Papadakis Dominik Richard Nick H Kim MERIT study investigators Source Type: research
Combined allergic bronchopulmonary mycosis and eosinophilic granulomatosis with polyangiitis: A case report and literature review
Respir Med Case Rep. 2024 Mar 19;48:102012. doi: 10.1016/j.rmcr.2024.102012. eCollection 2024.ABSTRACTA 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases co...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Ning Cui Jingluan Wang Yanmei Shao Jingming Zhao Zhaozhong Cheng Source Type: research
