Prevalence of nonaffective psychosis in intellectually disabled clients: systematic review and meta-analysis
Epidemiological studies report high rates of schizophrenia in individuals with intellectual disability (ID). However, this subject has not been reviewed systematically. We aim to review studies that report the prevalence of nonaffective psychosis in a population with ID and estimate the prevalence of schizophrenia in this population. We performed a literature search using the PsychINFO, MEDLINE and EMBASE (from inception to 2 October 2014). We performed a manual search of citations from relevant papers identified through the databases. We identified 887 titles and after screening abstracts, identified 60 full-text articles...
Source: Psychiatric Genetics - July 1, 2016 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Association study of rare nonsynonymous variants of FTO in bipolar disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Melatonin receptor 1B gene associated with hyperglycemia in bipolar disorder
This study reports that a functional genetic variant of MTNR1B, previously implicated in the impairment of glucose-stimulated insulin release also in schizophrenia, was associated with elevated fasting glucose levels in bipolar patients and controls. This finding suggests that the MTNR1B-dependent vulnerability for elevated fasting plasma glucose levels is shared between bipolar disorder and schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Association study of DISC1 genetic variants with the risk of schizophrenia
Our previous study confirmed that the ‘AA’ genotype carriers of DISC1 single nucleotide polymorphism (SNP) rs821616 had a significantly increased risk for schizophrenia (SCZ) in comparison with noncarriers. To further explore the relationship of DISC1 genetic variants with the risk of SCZ in Han Chinese, we designed the present two-step study. We sequenced the promoter and untranslated regions of the DISC1 gene using genomic DNA of 100 SCZ patients and identified 17 SNPs. All SNPs were then genotyped and analyzed through a case–control study with 1154 healthy controls and 1447 patients. In an association analysis, ne...
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China
Conclusion: In The Chinese Han population, APOE ε4 increased the risk of AD and MCI in a dose-dependent manner and ε2 decreased the risk of AD as reported previously. APOEε4 might increase risk in VaD and female patients with VCIND, but no effects of APOE on bvFTD, DLB, and SD were found. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents
Conclusion: Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood maltreatment experienced, among Chinese adolescents. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Long noncoding RNAs in psychiatric disorders
Long noncoding RNAs (lncRNAs) are nonprotein coding transcripts longer than 200 nucleotides. Many of these lncRNAs have regulatory functions and have recently emerged as major players in governing fundamental biological processes. Here, we review the definition, distribution, identification, databases, analysis, classification, and functions of lncRNAs. We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

IQSEC2 and X-linked syndromal intellectual disability
Despite the recent acceleration in the discovery of genetic risk factors for intellectual disability (ID), the genetic etiology of ID is unknown in approximately half of cases and remains a major frontier of genetics in medicine and psychiatry. The distinction between syndromal and nonsyndromal forms of ID is of great clinical importance, but the boundary between these clinical entities is difficult to ascertain for many genes of interest. ID is more common in men than in women, but the genetic explanation of this sex asymmetry is incompletely understood. This Review systematically examines the reported cases of X-linked I...
Source: Psychiatric Genetics - April 26, 2016 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Genetic variant analysis of the putative regulatory regions of the LRRC7 gene in bipolar disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2016 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

No association of GRIA1 polymorphisms with schizophrenia in the Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2016 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2016 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966
Patients with behavioral variant frontotemporal dementia (bvFTD) have many psychotic symptoms, especially at the onset of the disease. The C9ORF72 expansion is the most common genetic etiology observed with bvFTD and the prevalence of the expansion is notably high among Finnish bvFTD patients. The aim of this study was to evaluate the prevalence of the C9ORF72 expansion among the clearly characterized patients with psychosis, mainly schizophrenia, in early midlife. The C9ORF72 repeat sizes were analyzed in 130 (48% women) patients with psychosis from the Northern Finland Birth Cohort 1966 (N=11 017), the mean onset age b...
Source: Psychiatric Genetics - February 26, 2016 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Meta-analysis of the association between a serotonin transporter 5-HTTLPR polymorphism and smoking cessation
5-HTTLPR is one of the candidate genes influencing addiction. Recent studies have reported that the 5-HTTLPR genotype is associated with smoking behaviour, but its influence is still controversial. Thus, we reviewed the smoking-cessation outcomes among previously reported studies by comparing the 5-HTTLPR polymorphism. In total, eight studies including 3206 participants for the present meta-analysis were assessed and the S/S, S/L and L/L genotypes were compared with respect to smoking-cessation outcomes. The results of comparing 5-HTTLPR genotypes were as follows: odds ratio (OR)=1.044 and 95% confidence interval (CI)=0.75...
Source: Psychiatric Genetics - February 26, 2016 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior
Fatty acid desaturase genes (FADS1-FADS2) encode desaturases participating in the biosynthesis of long-chain polyunsaturated fatty acids. As long-chain polyunsaturated fatty acids are implicated in major depressive disorder (MDD) and suicide risk, and as both are partly heritable, we studied the association of FADS1-FADS2 polymorphisms with MDD (635 cases, 480 controls) and suicide attempt status (291 attempters, 344 MDD nonattempters). Eighteen FADS-related single-nucleotide polymorphisms were genotyped from Caucasians enrolled in Madrid (n=791) or New York City (n=324) and entered as predictors into logistic regression a...
Source: Psychiatric Genetics - February 26, 2016 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research