Buspirone for the treatment of anxiety-related symptoms in Angelman syndrome: a case series
Conclusion The findings of this study suggest that buspirone may be effective for the amelioration of behaviors related to anxiety in patients with AS, and well tolerated. Limitations include the open-label nature of these treatments, the small sample size and the absence of a control group. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia
Conclusion The numbers of variants involved are too small for firm conclusions to be drawn. The results are consistent with the hypothesis that ∼0.5% of patients with schizophrenia have disruptive or damaging genetic variants, which could plausibly impair functioning of NMDAR directly or indirectly through impairing Fyn function. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Missing a beat: assessment of circadian rhythm abnormalities in bipolar disorder in the genomic era
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of ‘clock genes’, robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. In recent years, very large genome-wide association studies (GWAS) have been conducted and the genetic underpinnings of BD are beginning to emerge. However, these genetic studies in BD do not match ...
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

Schizophrenia in microcephalic osteodysplastic primordial dwarfism type II syndrome: supporting evidence for an association between the: PCNT: gene and schizophrenia
In this report, we discuss the possible association between the PCNT gene and schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: BRIEF REPORT Source Type: research

Buspirone for the treatment of anxiety-related symptoms in Angelman syndrome: a case series
Conclusion The findings of this study suggest that buspirone may be effective for the amelioration of behaviors related to anxiety in patients with AS, and well tolerated. Limitations include the open-label nature of these treatments, the small sample size and the absence of a control group. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia
Conclusion The numbers of variants involved are too small for firm conclusions to be drawn. The results are consistent with the hypothesis that ∼0.5% of patients with schizophrenia have disruptive or damaging genetic variants, which could plausibly impair functioning of NMDAR directly or indirectly through impairing Fyn function. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Missing a beat: assessment of circadian rhythm abnormalities in bipolar disorder in the genomic era
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of ‘clock genes’, robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. In recent years, very large genome-wide association studies (GWAS) have been conducted and the genetic underpinnings of BD are beginning to emerge. However, these genetic studies in BD do not match ...
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

Genetic association of the human MAP3K5 gene with schizophrenia in a Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: BRIEF ASSOCIATION LETTER Source Type: research

Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals
Conclusion Our results propose that genetic variants located in the genomic region of the CamK2A gene may be involved in transition time from occasional to regular heroin use. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research

Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from: CNTNAP2: ,: ADGRL3: , and: PARK2
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients – CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system. By bringing together behavioral and neurobiological data, we demonstrate how a cross-species approach can provide ...
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

No association of GRIN2A polymorphisms with the major depressive disorder in the Chinese Han origin
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: BRIEF ASSOCIATION LETTER Source Type: research

Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia: a meta-analysis
Conclusion This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research

Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met
Conclusion Our results provide evidence of association between the DRD4 exon III VNTR polymorphism and novelty-seeking, which is inconsistent with the results of previous meta-analysis. Furthermore, several direct and indirect moderators are also identified to explain contradictory results in the existing literature. However, our results regarding COMT are consistent with those of previous meta-analysis. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research