GRIN2B mediates susceptibility to intelligence quotient and cognitive impairments in developmental dyslexia
Conclusion: Our results add further evidence in support of GRIN2B contributing toward DD and deficits in DD. More specifically, our data support the view that GRIN2B influences DD as a categorical trait and its related quantitative phenotypes, thus shedding further light on the etiologic basis and the phenotypic complexity of this disorder. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 6, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Association between the TPH1 A218C polymorphism and antidepressant response: evidence from an updated ethnicity, antidepressant-specific, and ethnicity–antidepressant interaction meta-analysis
Conclusion: The TPH1 A218C polymorphism may not be associated with antidepressant response either in an ethnicity, antidepressant-specific population or in an ethnicity–antidepressant interaction model. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 6, 2015 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

In memoriam: Hugh Malcolm Douglas Gurling
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Obituary Source Type: research

Association study of fibroblast growth factor genes and brain volumes in schizophrenic patients and healthy controls
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Lack of association between the GRM7 gene and attention deficit hyperactivity disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Smoking behaviour: investigation of the coaction of environmental and genetic risk factors
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea
The use of clozapine, an effective antipsychotic drug used in treatment-resistant schizophrenia, is associated with adverse effects. Sialorrhea is one such effect, which can be distressing for many patients. Studies on the pharmacogenetics of the adverse effects of clozapine are limited. The aim of the present study was to determine whether clozapine-induced sialorrhea is associated with a 120 base-pairs (bp) tandem duplication polymorphism in the dopamine receptor subtype D4 (DRD4) gene. Ninety-five patients, mean age 35.43±9.43 years, with treatment-resistant schizophrenia and on clozapine were included in the study. De...
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes
Velocardiofacial (VCFS; 22q11.2 deletion) syndrome is a genetic disorder that results from a hemizygous deletion of the q11.2 region on chromosome 22, and is associated with greatly increased risk for psychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia. There is emerging evidence for the involvement of catechol-O-methyltransferase (COMT) and proline dehydrogenase (oxidase) 1 (PRODH) in the psychiatric phenotype of individuals with VCFS. Here, we tested the hypothesis that PRODH and COMT are associated with ASD in youths with VCFS. We found that individuals with VCFS and the low-activity allele...
Source: Psychiatric Genetics - November 3, 2014 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research