A case of Nablus mask-like facial syndrome with autism spectrum disorders
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Letter to the Editor Source Type: research
No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population
In this study, we chose seven SNPs (two BRD1 SNPs, five ZBED4 SNPs) to carry out an association study between these two genes and schizophrenia in the Chinese population. However, no significant result was obtained, which was consistent with the Japanese population. Taken together, we could conclude that BRD1 and ZBED4 might be population specific in schizophrenia and may not account for a substantial proportion of genetic risk for schizophrenia in the Asian population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research
Associations between the brain-derived neurotrophic factor Val66Met polymorphisms and suicide in patients with cancer
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research
Shared genetic etiology between alcohol dependence and major depressive disorder
The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a (∼10 fold) larger discovery sample, we calculated PRS based on the second wave (PGC-MDD2) of results, in a severe AD case–control target sample. We found significant associations between AD disease status and MDD-PRS derived from both PG...
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research
Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets
Conclusion
The multiple SNP associations observed in schizophrenia may result from other mechanisms, including effects mediated indirectly through environmental risk factors. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Original Article Source Type: research
High-functioning autism in a Sri Lankan youth with Langer–Giedion syndrome
The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer–Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer–Giedion syndrome and high-functioning autism. The karyotype found a microdeletion of the long arm of chromosome 8 with mosaicism [46,XY/46,XY,del(8)(q24.1q24.3)]. This is probably the first report of Langer–Giedion Syndrome with autism and the first report of the genetic syndrome from Sri Lanka. Furthermo...
Source: Psychiatric Genetics - May 2, 2018 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research
Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia
Conclusion
Our findings suggest that the COMT gene polymorphisms may influence the response to antipsychotic treatment in Han Chinese patients with schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
MTHFR gene methylation is associated with perceived stress in healthy young adults
Conclusion
To our knowledge, this is the first study that reports an association between perceived stress and MTHFR methylation levels. This report adds evidence to the emerging role of epigenetic changes in endophenotypes related to affective disorders. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
No association of NR3C1 polymorphisms with major depressive disorder in the Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research
Integrated analysis of the genetic basis of suicidal behavior: what has been shown by structural genetic studies so far
Conclusion
Like other behavioral disorders, suicide has a complex and multifactorial basis and at present, the only approaches to the integrated study of such disorders are computer-based methods. The results of such studies, although subject to a degree of uncertainty, however, can pave the way for future basic and clinical studies. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Familial risk for psychiatric disorders in military veterans who have post-traumatic stress disorder with psychosis: a retrospective electronic record review
Aims/Objectives/Background
Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD.
Methods
Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder. PTSD...
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
No association between FOXP2 rs10447760 and schizophrenia in a replication study of the Chinese Han population
Conclusion
Thus, our results did not support the association between FOXP2 rs10447760 and schizophrenia in a Chinese Han population, and large-scale genetic replication studies with different racial and geographic origins are required in the future. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Lack of association between triggering receptor expressed on myeloid cells 2 polymorphism rs75932628 and late-onset Alzheimer’s disease in a Chinese Han population
We examined 786 patients and 803 controls in this study. The rs75932628 polymorphism was evaluated using high-resolution melting analysis and direct sequencing. rs75932628-T (predicted to cause an R47H substitution) was absent in our cohort. We did not find an association between the rs75932628 single nucleotide polymorphism of TREM2 and LOAD in this study. Thus, rs75932628 is unlikely to be related to LOAD in the Chinese Han population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 17, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
Investigation of differential HDAC4 methylation patterns in eating disorders
The objective of this study was to investigate the relationship between methylation patterns of the histone deacetylase 4 gene and eating disorders in a site previously associated with anorexia nervosa (AN). Women with AN (N=28) or bulimia nervosa (BN) (N=19) were age-matched and sex-matched to controls (N=45). We obtained saliva-derived DNA and use bisulfite pyrosequencing to examine region-specific methylation differences between cases and controls. The region assayed includes 15 CpGs. We found no significant association between the previously implicated CpG and either AN or BN. We found that three CpGs were nominally as...
Source: Psychiatric Genetics - January 17, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
Association study of FGF18 with developmental dyslexia in Chinese population
Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools. However, we did not observe any single nucleotide polymorphism exceed...
Source: Psychiatric Genetics - January 17, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
