Genotype-phenotype feasibility studies on khat abuse, traumatic experiences and psychosis in Ethiopia
Studying the relationship between mental illnesses and their environmental and genetic risk factors in low-income countries holds excellent promises. These studies will improve our understanding of how risk factors identified predominantly in high-income countries also apply to other settings and will identify new, sometimes population-specific risk factors. Here we report the successful completion of two intertwined pilot studies on khat abuse, trauma, and psychosis at the Gilgel Gibe Field Research Center in Ethiopia. We found that the Gilgel Gibe Field Research Center offers a unique opportunity to collect well-characte...
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

No association between CYP2C19 genetic polymorphism with treatment remission to antidepressant venlafaxine in Han Chinese population
Conclusion: CYP2C19 genetic polymorphism may not have association with SNRI venlafaxine treatment remission in the Han Chinese population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Modification of the association between paroxetine serum concentration and SERT-occupancy by ABCB1 (P-glycoprotein) polymorphisms in major depressive disorder
Conclusion Pharmacokinetic influences of the ABCB1 rs1128503 and rs2032582 represent a potentially relevant pharmacogenetic mechanism to consider when evaluating paroxetine efficacy. Future studies are needed to support the role of ABCB1 genotyping for individualizing SSRI pharmacotherapy. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Catechol-O-methyltransferase gene expression in stress-induced and non-stress induced schizophrenia
Conclusion This data supports that reduced blood catechol-O-methyltransferase expression, which may be associated with higher dopamine level, is involved both in stress-induced and non-stress–induced schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights
Schizophrenia is a common multigenic and debilitating neurological disorder characterized by chronic psychotic symptoms and psychosocial impairment. Complex interactions of genetics and environmental factors have been implicated in etiology of schizophrenia. There is no central pathophysiology mechanism, diagnostic neuropathology, or biological markers have been defined for schizophrenia. However, a number of different hypotheses including neurodevelopmental and neurochemical hypotheses have been proposed to explain the neuropathology of schizophrenia. This review provides an overview of pathogenesis, genetic and environme...
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

A case of intellectual disability reveals a novel mutation in IQSEC2 gene by whole exome sequencing
Intellectual disability refers to significantly subaverage intellectual function (intelligence quotient (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 4, 2019 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Corpus callosum metrics predict severity of visuospatial and neuromotor dysfunctions in ARID1B mutations with Coffin–Siris syndrome
ARID1B mutations in Coffin–Siris syndrome are a cause of intellectual disability (0.5–1%), with various degrees of autism and agenesis of the corpus callosum (10%). Little is known regarding the cognitive and motor consequences of ARID1B mutations in humans and no link has been made between corpus callosum anomalies and visuospatial and neuromotor dysfunctions. We have investigated the visuospatial and neuromotor phenotype in eight patients with ARID1B mutations. A paramedian sagittal section of the brain MRI was selected, and corpus callosum was measured in anteroposterior length, genu and trunk width. Spearma...
Source: Psychiatric Genetics - November 4, 2019 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Association between RELN polymorphisms and schizophrenia in a Han population from Northeast China
Conclusion Our study provides and supports the evidence that RELN is a candidate gene for schizophrenia. Replication studies conducted in different populations are required, and the sex-specific association of this gene with schizophrenia warrants further exploration. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 4, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Association study of the PDE4D gene and obsessive-compulsive disorder in a Chinese Han population
Objective Multiple evidence suggests an involvement of the PDE4D in mental disorders. Therefore we investigate the association between obsessive-compulsive disorder and a polymorphism of the single nucleotide polymorphisms of PDE4D gene in the Chinese Han population. Methods We genotyped and performed a case-control association analysis of the PDE4D polymorphism rs1838733 in 400 obsessive-compulsive disorder patients and 459 healthy control subjects. Results The site conformed to Hardy–Weinberg (P> 0.05), three genotypes (AA, AG, GG) of PDE4D gene rs1838733 were detected. We demonstrated three principal re...
Source: Psychiatric Genetics - November 4, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Clinical association to FKBP5 rs1360780 in patients with depression
The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater...
Source: Psychiatric Genetics - November 4, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Endophenotypes of executive functions in obsessive compulsive disorder? A meta-analysis in unaffected relatives
Endophenotypes are mediator traits between genetic influences and clinical phenotypes. Meta-analyses have consistently shown modest impairments of executive functioning in obsessive compulsive disorder (OCD) patients compared to healthy controls. Similar deficits have also been reported in unaffected relatives of OCD patients, but have not been quantified. We conducted the first meta-analysis combining all studies investigating executive functioning in unaffected relatives of individuals with OCD to quantify any deficits. A search of Pubmed, Medline and PsychInfo databases identified 21 suitable papers comprising 707 unaff...
Source: Psychiatric Genetics - November 4, 2019 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

Brain-derived neurotrophic factor and schizophrenia
The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. Brain-derived neurotrophic factor biosynthesis and secretion are chrono-topically regulated processes at the cellular level, accounting for specific localizations and functions. Given its role in regulating brain development and activity, BDNF represents a potentially relevant gene for schizophrenia, and indeed BDNF and its non-synonymous functional variant, rs6265 (C → T, Val → Met) have been widely studied in ps...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Gene knockout animal models of depression, anxiety and obsessive compulsive disorders
In the past decades, the improving knowledge of genes implicated in the pathogenesis of psychiatric disorders together with the advancements in genetic engineering has led to the creation of mice in which one or more genes are inactivated or ‘knocked out’. Knockout mice are extensively used to better investigate the molecular and cellular mechanisms underlying these diseases as well as the biological role of specific genes. Moreover, they are also useful tools for developing new therapeutic strategies. The success of using knockout mice is possible due to availability of several models used to mimic some clinic...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool
There are substantial differences, or variation, between humans in aggression, with its molecular genetic basis mostly unknown. This review summarizes knowledge on the genetic contribution to variation in aggression with the following three foci: (1) a comprehensive overview of reviews on the genetics of human aggression, (2) a systematic review of genome-wide association studies (GWASs), and (3) an automated tool for the selection of literature based on supervised machine learning. The phenotype definition ‘aggression’ (or ‘aggressive behaviour’, or ‘aggression-related traits’) included...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Offspring of parents with schizophrenia, bipolar disorder, and depression: a review of familial high-risk and molecular genetics studies
Offspring of parents with severe mental illness, including schizophrenia, bipolar disorder, and major depressive disorder, have a one-in-three risk of developing severe mental illness themselves. Over the last 60 years, three waves of familial high-risk studies examined the development of severe mental illness in offspring of affected parents. The first two waves established familial nature of schizophrenia, and demonstrated early impairment in offspring of affected parents. The most recent wave has added a focus on mood disorders and examined the transdiagnostic nature of familial risk. A synthesis of current knowledge on...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges
Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a large number of common variants each with a small effect and many genetic variants influence more than one phenotype, suggesting shared genetic etiology. These concepts have the potential to revolutionize the current classification system with diagnostic categories and facilitate development of better treatments. However, to reach clinical impact, we need larger samples and better analytical tools, as mos...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

New insights and perspectives on the genetics of obsessive-compulsive disorder
Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Zinc finger proteins in psychiatric disorders and response to psychotropic medications
Zinc finger proteins are a large family of abundantly expressed small motifs that play a crucial role in a wide range of physiological and pathophysiological mechanisms. Findings published so far support an involvement of zinc fingers in psychiatric disorders. Most of the evidence has been provided for the zinc finger protein 804A (ZNF804A) gene, which has been suggested to be implicated in schizophrenia and bipolar disorder. This evidence has been corroborated by a wide range of functional studies showing that ZNF804A regulates the expression of genes involved in cell adhesion and plays a crucial role in neurite formation...
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Review Articles Source Type: research

Psychiatric Genetics, where we have been and where we are going
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - September 5, 2019 Category: Genetics & Stem Cells Tags: Editorial Source Type: research

Decreased serum complement component 4 levels in patients with schizophrenia
This study investigated the association between the level of serum component 4 and schizophrenia. Data were derived from a case-control association study of 40 unrelated adult patients with schizophrenia and 40 matched healthy controls. The component 4 level in serum was measured for comparative analysis by a component 4 enzyme-linked immunosorbent assay kit. Our findings suggest that the serum component 4 level is lower in patients with schizophrenia than in the controls, and the results apply to both males and females. Our results will lay an important foundation for establishing diagnostic methods and provide feasible a...
Source: Psychiatric Genetics - June 27, 2019 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

Common variants in SATB2 are associated with schizophrenia in Uygur Chinese population
Conclusion Our results suggest that SATB2 is also a susceptibility gene for schizophrenia in Uygur Chinese population, and subsequent functional experiments are necessary to reveal its role in the pathogenesis. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 27, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Determining population stratification and subgroup effects in association studies of rare genetic variants for nicotine dependence
Background Rare variants (minor allele frequency (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 27, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Anorexia nervosa is associated with Neuronatin variants
Conclusion Our data suggest that NNAT variants and NNAT expression changes may be associated with susceptibility to eating disorders such as anorexia nervosa. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 27, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The interaction between estradiol change and the serotonin transporter gene (5-HTTLPR) polymorphism is associated with postpartum depressive symptoms
Although estrogenic fluctuation is considered a major risk factor for postpartum depression (PPD), the effects of the interactions between the genetic background and estradiol (E2) change on PPD are not well understood. Here, a cohort study with 437 postpartum women was carried out to evaluate the role of a serotonin transporter gene polymorphism (5-HTTLPR) and E2 change on the risk of PPD symptoms. The participants were assessed using the Edinburgh Postnatal Depression Scale and the Self-Rating Depression Scale at 1 and 6 weeks after delivery. The PCR-based restriction fragment length polymorphism method was utilized to e...
Source: Psychiatric Genetics - June 27, 2019 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

In memoriam: Ting-Kai Li (1934–2018)
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 19, 2019 Category: Genetics & Stem Cells Tags: Commentary Source Type: research

Understanding the schizophrenia phenotype in the first patient with the full SCN2A phenotypic spectrum
We report on a 38-year-old patient with adult-onset psychotic symptoms on a background of infantile-onset seizures, autistic features and episodic ataxia. Whole-exome sequencing revealed a de-novo novel SCN2A mutation (c.4966T > C, p.Ser1656Pro). This and other SCN2A mutations associated with the schizophrenia phenotype overlap those seen in neurodevelopmental disorders, suggesting a common underlying mechanism. This is the first report of a patient with the entire known SCN2A phenotypic spectrum. We highlight the importance of recognizing the psychiatric phenotypes associated with SCN2A mutations and that...
Source: Psychiatric Genetics - April 19, 2019 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Autism spectrum disorder in a patient with a genomic rearrangement that only involves the EPHA5 gene
In this report, we describe the case of a 14-year-old female Italian proband affected by ASD, carrying a novel ~ 270 kb interstitial microduplication, localized at the distal portion of the 4q13.1 region. The rearrangement was inherited from a mild symptomatic father and included a large part of the single EPHA5 gene, a receptor tyrosine kinase involved in the neural development, already indicated to be linked to ASD by previous Genome Wide Association Studies. This imbalance represents, to the best of our knowledge, the smallest duplication identified to date that only impacts the EPHA5 gene. We hypothesize ...
Source: Psychiatric Genetics - April 19, 2019 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China
Conclusion This study did not support the effect of these seven serotonergic gene polymorphisms on attempted suicide in rural China. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - April 19, 2019 Category: Genetics & Stem Cells Tags: Original Article Source Type: research

Genetic risk factors and gene–environment interactions in adult and childhood attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, genetic studies have revealed several risk gene variants associated with ADHD; however, these variants could only be partly replicated and are responsible for only a fraction of the whole heritability of ADHD estimated from family and twin studies. One factor that could potentially explain the ‘missing heritability’ of ADHD is that childhood and adult or persistent ADHD could be genetically distinct subtypes, which therefore need to be analyzed separately. Another approach to identify t...
Source: Psychiatric Genetics - April 19, 2019 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

Schizophrenia in microcephalic osteodysplastic primordial dwarfism type II syndrome: supporting evidence for an association between the: PCNT: gene and schizophrenia
In this report, we discuss the possible association between the PCNT gene and schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: BRIEF REPORT Source Type: research

Buspirone for the treatment of anxiety-related symptoms in Angelman syndrome: a case series
Conclusion The findings of this study suggest that buspirone may be effective for the amelioration of behaviors related to anxiety in patients with AS, and well tolerated. Limitations include the open-label nature of these treatments, the small sample size and the absence of a control group. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia
Conclusion The numbers of variants involved are too small for firm conclusions to be drawn. The results are consistent with the hypothesis that ∼0.5% of patients with schizophrenia have disruptive or damaging genetic variants, which could plausibly impair functioning of NMDAR directly or indirectly through impairing Fyn function. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Missing a beat: assessment of circadian rhythm abnormalities in bipolar disorder in the genomic era
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of ‘clock genes’, robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. In recent years, very large genome-wide association studies (GWAS) have been conducted and the genetic underpinnings of BD are beginning to emerge. However, these genetic studies in BD do no...
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

Schizophrenia in microcephalic osteodysplastic primordial dwarfism type II syndrome: supporting evidence for an association between the: PCNT: gene and schizophrenia
In this report, we discuss the possible association between the PCNT gene and schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: BRIEF REPORT Source Type: research

Buspirone for the treatment of anxiety-related symptoms in Angelman syndrome: a case series
Conclusion The findings of this study suggest that buspirone may be effective for the amelioration of behaviors related to anxiety in patients with AS, and well tolerated. Limitations include the open-label nature of these treatments, the small sample size and the absence of a control group. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia
Conclusion The numbers of variants involved are too small for firm conclusions to be drawn. The results are consistent with the hypothesis that ∼0.5% of patients with schizophrenia have disruptive or damaging genetic variants, which could plausibly impair functioning of NMDAR directly or indirectly through impairing Fyn function. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Missing a beat: assessment of circadian rhythm abnormalities in bipolar disorder in the genomic era
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of ‘clock genes’, robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. In recent years, very large genome-wide association studies (GWAS) have been conducted and the genetic underpinnings of BD are beginning to emerge. However, these genetic studies in BD do no...
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

Genetic association of the human MAP3K5 gene with schizophrenia in a Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: BRIEF ASSOCIATION LETTER Source Type: research

Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals
Conclusion Our results propose that genetic variants located in the genomic region of the CamK2A gene may be involved in transition time from occasional to regular heroin use. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research

Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from: CNTNAP2: ,: ADGRL3: , and: PARK2
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients – CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system. By bringing together behavioral and neurobiological data, we demonstrate how a cross-species approach can prov...
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

No association of GRIN2A polymorphisms with the major depressive disorder in the Chinese Han origin
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: BRIEF ASSOCIATION LETTER Source Type: research

Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia: a meta-analysis
Conclusion This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research

Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met
Conclusion Our results provide evidence of association between the DRD4 exon III VNTR polymorphism and novelty-seeking, which is inconsistent with the results of previous meta-analysis. Furthermore, several direct and indirect moderators are also identified to explain contradictory results in the existing literature. However, our results regarding COMT are consistent with those of previous meta-analysis. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research

Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia
In this study, we focused on the association between rare genetic variants of GLO1 and schizophrenia. First, we identified one heterozygous frameshift variant, p.P122fs, in 370 Japanese schizophrenia cases with allele frequencies of up to 1% by exon-targeted mutation screening of GLO1. We then performed an association analysis on 1282 cases and 1764 controls with this variant. The variant was found in three cases and eight controls. There was no statistically significant association between p.P122fs in GLO1 and schizophrenia (P=0.25). This frameshift variant in GLO1 might occur at near-polymorphic frequencies in the Japane...
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia
This study aims to explore the distribution of the schizophrenia PRS in subjects of different ancestry. Methods The schizophrenia PRS derived from the large genome-wide association study carried out by the Psychiatric Genetics Consortium was calculated using the downloaded genotypes of HapMap subjects from 11 different ancestral groups. It was also calculated using downloaded genotypes of European schizophrenia cases and controls from the CommonMind Consortium. Results The PRS for schizophrenia varied significantly between ancestral groups (P (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder
Conclusion Our results provide genetic evidence supporting associations between hippocampal volume and MDD, which may reflect underlying cellular stress responses. Our study provides evidence of biological mechanisms that should be further explored in the search for disease-modifying therapeutic targets for depression. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?: Erratum
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Erratum Source Type: research