Buspirone for the treatment of anxiety-related symptoms in Angelman syndrome: a case series
Conclusion
The findings of this study suggest that buspirone may be effective for the amelioration of behaviors related to anxiety in patients with AS, and well tolerated. Limitations include the open-label nature of these treatments, the small sample size and the absence of a control group. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research
In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia
Conclusion
The numbers of variants involved are too small for firm conclusions to be drawn. The results are consistent with the hypothesis that ∼0.5% of patients with schizophrenia have disruptive or damaging genetic variants, which could plausibly impair functioning of NMDAR directly or indirectly through impairing Fyn function. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research
Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion
Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research
Missing a beat: assessment of circadian rhythm abnormalities in bipolar disorder in the genomic era
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of ‘clock genes’, robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. In recent years, very large genome-wide association studies (GWAS) have been conducted and the genetic underpinnings of BD are beginning to emerge. However, these genetic studies in BD do not match ...
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research
Genetic association of the human MAP3K5 gene with schizophrenia in a Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: BRIEF ASSOCIATION LETTER Source Type: research
Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals
Conclusion
Our results propose that genetic variants located in the genomic region of the CamK2A gene may be involved in transition time from occasional to regular heroin use. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research
Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from: CNTNAP2: ,: ADGRL3: , and: PARK2
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients – CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system. By bringing together behavioral and neurobiological data, we demonstrate how a cross-species approach can provide ...
Source: Psychiatric Genetics - January 7, 2019 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research
No association of GRIN2A polymorphisms with the major depressive disorder in the Chinese Han origin
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: BRIEF ASSOCIATION LETTER Source Type: research
Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia: a meta-analysis
Conclusion
This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research
Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met
Conclusion
Our results provide evidence of association between the DRD4 exon III VNTR polymorphism and novelty-seeking, which is inconsistent with the results of previous meta-analysis. Furthermore, several direct and indirect moderators are also identified to explain contradictory results in the existing literature. However, our results regarding COMT are consistent with those of previous meta-analysis. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Tags: REVIEW ARTICLE Source Type: research
Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research
Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia
In this study, we focused on the association between rare genetic variants of GLO1 and schizophrenia. First, we identified one heterozygous frameshift variant, p.P122fs, in 370 Japanese schizophrenia cases with allele frequencies of up to 1% by exon-targeted mutation screening of GLO1. We then performed an association analysis on 1282 cases and 1764 controls with this variant. The variant was found in three cases and eight controls. There was no statistically significant association between p.P122fs in GLO1 and schizophrenia (P=0.25). This frameshift variant in GLO1 might occur at near-polymorphic frequencies in the Japane...
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia
This study aims to explore the distribution of the schizophrenia PRS in subjects of different ancestry.
Methods
The schizophrenia PRS derived from the large genome-wide association study carried out by the Psychiatric Genetics Consortium was calculated using the downloaded genotypes of HapMap subjects from 11 different ancestral groups. It was also calculated using downloaded genotypes of European schizophrenia cases and controls from the CommonMind Consortium.
Results
The PRS for schizophrenia varied significantly between ancestral groups (P (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder
Conclusion
Our results provide genetic evidence supporting associations between hippocampal volume and MDD, which may reflect underlying cellular stress responses. Our study provides evidence of biological mechanisms that should be further explored in the search for disease-modifying therapeutic targets for depression. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?: Erratum
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Erratum Source Type: research
