Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder
Conclusion Our results provide genetic evidence supporting associations between hippocampal volume and MDD, which may reflect underlying cellular stress responses. Our study provides evidence of biological mechanisms that should be further explored in the search for disease-modifying therapeutic targets for depression. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 31, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?: Erratum
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Erratum Source Type: research

A case of Nablus mask-like facial syndrome with autism spectrum disorders
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Letter to the Editor Source Type: research

No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population
In this study, we chose seven SNPs (two BRD1 SNPs, five ZBED4 SNPs) to carry out an association study between these two genes and schizophrenia in the Chinese population. However, no significant result was obtained, which was consistent with the Japanese population. Taken together, we could conclude that BRD1 and ZBED4 might be population specific in schizophrenia and may not account for a substantial proportion of genetic risk for schizophrenia in the Asian population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Associations between the brain-derived neurotrophic factor Val66Met polymorphisms and suicide in patients with cancer
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Shared genetic etiology between alcohol dependence and major depressive disorder
The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a (∼10 fold) larger discovery sample, we calculated PRS based on the second wave (PGC-MDD2) of results, in a severe AD case–control target sample. We found significant associations between AD disease status and MDD-PRS derived from both PG...
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets
Conclusion The multiple SNP associations observed in schizophrenia may result from other mechanisms, including effects mediated indirectly through environmental risk factors. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 30, 2018 Category: Genetics & Stem Cells Tags: Original Article Source Type: research

High-functioning autism in a Sri Lankan youth with Langer–Giedion syndrome
The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer–Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer–Giedion syndrome and high-functioning autism. The karyotype found a microdeletion of the long arm of chromosome 8 with mosaicism [46,XY/46,XY,del(8)(q24.1q24.3)]. This is probably the first report of Langer–Giedion Syndrome with autism and the first report of the genetic syndrome from Sri Lanka. Furthermo...
Source: Psychiatric Genetics - May 2, 2018 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia
Conclusion Our findings suggest that the COMT gene polymorphisms may influence the response to antipsychotic treatment in Han Chinese patients with schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

MTHFR gene methylation is associated with perceived stress in healthy young adults
Conclusion To our knowledge, this is the first study that reports an association between perceived stress and MTHFR methylation levels. This report adds evidence to the emerging role of epigenetic changes in endophenotypes related to affective disorders. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

No association of NR3C1 polymorphisms with major depressive disorder in the Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research

Integrated analysis of the genetic basis of suicidal behavior: what has been shown by structural genetic studies so far
Conclusion Like other behavioral disorders, suicide has a complex and multifactorial basis and at present, the only approaches to the integrated study of such disorders are computer-based methods. The results of such studies, although subject to a degree of uncertainty, however, can pave the way for future basic and clinical studies. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Familial risk for psychiatric disorders in military veterans who have post-traumatic stress disorder with psychosis: a retrospective electronic record review
Aims/Objectives/Background Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. Methods Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder. PTSD...
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

No association between FOXP2 rs10447760 and schizophrenia in a replication study of the Chinese Han population
Conclusion Thus, our results did not support the association between FOXP2 rs10447760 and schizophrenia in a Chinese Han population, and large-scale genetic replication studies with different racial and geographic origins are required in the future. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 2, 2018 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Lack of association between triggering receptor expressed on myeloid cells 2 polymorphism rs75932628 and late-onset Alzheimer’s disease in a Chinese Han population
We examined 786 patients and 803 controls in this study. The rs75932628 polymorphism was evaluated using high-resolution melting analysis and direct sequencing. rs75932628-T (predicted to cause an R47H substitution) was absent in our cohort. We did not find an association between the rs75932628 single nucleotide polymorphism of TREM2 and LOAD in this study. Thus, rs75932628 is unlikely to be related to LOAD in the Chinese Han population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 17, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research