Impact of sensory impairments on dementia incidence and symptoms among Japanese older adults
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2020 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

The effect of masticatory behaviour on generalized attention in heathy volunteers
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2020 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

A retrospective study on the diagnosis and treatment of dementia in patients referred to the Sagamihara Municipal Medical Center for Dementia for consultation
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2020 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Anxiety symptoms are quantitatively and qualitatively different in dementia with Lewy bodies than in Alzheimer's disease in the years preceding clinical diagnosis
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2020 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Message from the New Editor‐in‐Chief
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2020 Category: Genetics & Stem Cells Tags: EDITORIAL Source Type: research

Issue Information
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2020 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION: PDF Only Source Type: research

Whole-exome sequencing in a family with a monozygotic twin pair concordant for schizophrenia and a follow-up case-control study of identified de-novo variants
Whole-exome sequencing (WES) studies have shown that de-novo variants contribute to the genetic etiology of schizophrenia. WES studies of families with a monozygotic twin pair concordant or discordant for a disease may be fruitful for identifying de-novo pathogenic variants. Here, we performed WES in six individuals from one family (affected monozygotic twins, their unaffected parents, and two siblings) and identified three de-novo missense variants (CPT2 Ala283Thr, CPSF3 Val584Ile, and RNF148 Val210Ile) in the monozygotic twin pair concordant for schizophrenia. These three missense variants were not found in 1760 patients...
Source: Psychiatric Genetics - March 14, 2020 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

A preliminary exome sequence in three patients with tardive dystonia
Tardive dystonia is one of the most serious adverse events that can be caused by antipsychotic treatment, but few studies have examined the etiology of tardive dystonia, and no genetic study using a next-generation sequencing technique has been performed to date. We conducted exome sequencing in three subjects with severe tardive dystonia. We analyzed the results focusing on candidate genes of primary dystonia, for example, TOR1A, GCH1, TH, THAP1, and SGCE. There were no single-nucleotide polymorphisms of these dystonia genes that were commonly shared among our subjects. Instead, the results revealed the presence of rare m...
Source: Psychiatric Genetics - March 14, 2020 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Does 5-HTTLPR moderate the effect of the quality of environmental context on maternal sensitivity? Testing the differential susceptibility hypothesis
Evidence documenting associations between 5-HTTLPR and parenting behavior led to testing the hypothesis that this polymorphism moderates the effect of the quality of environmental context on maternal sensitivity. Participants were 210 Portuguese mothers and their preschool children, recruited from the community. An index reflecting the quality of the environmental context was derived based on nine markers (e.g. single parenthood; parental education, economic difficulties, family conflict, maternal psychopathology). Maternal sensitivity was measured observationally. Maternal saliva was collected with OraGene kits for geneti...
Source: Psychiatric Genetics - March 14, 2020 Category: Genetics & Stem Cells Tags: Original Article Source Type: research

Transient receptor potential vanilloid 1 antagonism in neuroinflammation, neuroprotection and epigenetic regulation: potential therapeutic implications for severe psychiatric disorders treatment
Transient receptor potential vanilloid 1 (TRPV1) is a polymodal cation channel gated by a large array of chemical and physical stimuli and distributed across different brain regions on neuronal and glial cells. Preclinical studies indicate that TRPV1 might be a target for the treatment of anxiety, depression and addictive disorders. The aim of this narrative review is to focus on studies examining the effects of TRPV1 antagonism on neuroinflammation, neuroprotection and epigenetic regulation. Results suggest that TRPV1 modulation leads to pro- or anti-inflammatory effects depending on the cytokine environment and that the ...
Source: Psychiatric Genetics - March 14, 2020 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

Genotype-phenotype feasibility studies on khat abuse, traumatic experiences and psychosis in Ethiopia
Studying the relationship between mental illnesses and their environmental and genetic risk factors in low-income countries holds excellent promises. These studies will improve our understanding of how risk factors identified predominantly in high-income countries also apply to other settings and will identify new, sometimes population-specific risk factors. Here we report the successful completion of two intertwined pilot studies on khat abuse, trauma, and psychosis at the Gilgel Gibe Field Research Center in Ethiopia. We found that the Gilgel Gibe Field Research Center offers a unique opportunity to collect well-characte...
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

No association between CYP2C19 genetic polymorphism with treatment remission to antidepressant venlafaxine in Han Chinese population
Conclusion: CYP2C19 genetic polymorphism may not have association with SNRI venlafaxine treatment remission in the Han Chinese population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Modification of the association between paroxetine serum concentration and SERT-occupancy by ABCB1 (P-glycoprotein) polymorphisms in major depressive disorder
Conclusion Pharmacokinetic influences of the ABCB1 rs1128503 and rs2032582 represent a potentially relevant pharmacogenetic mechanism to consider when evaluating paroxetine efficacy. Future studies are needed to support the role of ABCB1 genotyping for individualizing SSRI pharmacotherapy. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Catechol-O-methyltransferase gene expression in stress-induced and non-stress induced schizophrenia
Conclusion This data supports that reduced blood catechol-O-methyltransferase expression, which may be associated with higher dopamine level, is involved both in stress-induced and non-stress–induced schizophrenia. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights
Schizophrenia is a common multigenic and debilitating neurological disorder characterized by chronic psychotic symptoms and psychosocial impairment. Complex interactions of genetics and environmental factors have been implicated in etiology of schizophrenia. There is no central pathophysiology mechanism, diagnostic neuropathology, or biological markers have been defined for schizophrenia. However, a number of different hypotheses including neurodevelopmental and neurochemical hypotheses have been proposed to explain the neuropathology of schizophrenia. This review provides an overview of pathogenesis, genetic and environme...
Source: Psychiatric Genetics - January 10, 2020 Category: Genetics & Stem Cells Tags: Review Article Source Type: research