Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist
Major depression disorder (MDD) is a complex neuropsychiatric disorder and an increasing number of genetic risk variants are being identified. Investigation of their influence in the general population requires accurate and efficient assessment of depressive symptoms. Here, clinical interviews conducted by clinicians are the gold standard. We investigated whether valid and reliable clinical phenotypes can be obtained efficiently using self-administered instruments. Lifetime depressive symptoms and lifetime MDD diagnosis were assessed in 464 population-based individuals using a clinical interview and a structured, self-admi...
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes
Conclusion: These findings indicate that TPH1, TPH2, and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred
Conclusion: Our findings add to the growing evidence of genetic risk factors that act pleiotropically to increase the risk for several neuropsychiatric disorders, including depression and SA, irrespective of ancestry. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Longitudinal changes of associations between the preproghrelin Leu72Met polymorphism with depression in Chinese Han adolescents after the Wenchuan earthquake
Conclusion: These results suggest that the 72Met allele of the preproghrelin Leu72Met polymorphism may be associated with rehabilitation of depression in male Chinese Han adolescents after the natural disaster. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 6, 2017 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research

Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa
Anorexia nervosa (AN) is a serious and heritable psychiatric disorder. To date, studies of copy number variants (CNVs) have been limited and inconclusive because of small sample sizes. We conducted a case-only genome-wide CNV survey in 1983 female AN cases included in the Genetic Consortium for Anorexia Nervosa. Following stringent quality control procedures, we investigated whether pathogenic CNVs in regions previously implicated in psychiatric and neurodevelopmental disorders were present in AN cases. We observed two instances of the well-established pathogenic CNVs in AN cases. In addition, one case had a deletion in th...
Source: Psychiatric Genetics - July 6, 2017 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

The role of microRNAs in the therapeutic action of D-cycloserine in a post-traumatic stress disorder animal model: an exploratory study
Conclusion: These differentially expressed miRNAs may be mediators of gene expression changes that facilitated decreased neuronal inflammation, optimum learning and memory and contributed towards effective fear extinction and reduction of anxiety following the co-administration of DCS and behavioural fear extinction. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 6, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Analysis of shared homozygosity regions in Saudi siblings with attention deficit hyperactivity disorder
Conclusion: The candidate regions identified in this study highlight the genetic diversity of ADHD. Upon further investigation, these loci may reveal candidate genes that enclose variants associated with ADHD. Although most ADHD studies were conducted in other populations, our study provides insight from an understudied, ethnically interesting population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 6, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Apolipoprotein E variants and genetic susceptibility to combat-related post-traumatic stress disorder: a meta-analysis
Conclusion: The current meta-analysis provides corroborating evidence that supports the fact that the presence of the APOE e4 polymorphism confers greater susceptibility to combat-related PTSD. Future studies with a larger sample size and better consistency in reporting standards are warranted to further evaluate these associations. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 6, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

L-Methylfolate supplementation in a child with autism and methyltetrahydrofolate reductase, enzyme gene C677TT allele
We report a case where L-methylfolate supplementation improved symptoms of aggression and disruptive behavior in a child with autism who tested positive for the C677TT allele of the methyltetrahydrofolate reductase enzyme gene. To our knowledge, this is the first report of L-methylfolate administration in this situation. Further controlled studies of L-methylfolate in this population are warranted. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 3, 2017 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Genetic variation in GABRβ1 and the risk for developing alcohol dependence
Associations between the γ-aminobutyric acid type-A receptors (GABAA) and alcohol dependence risk have been reported, although the receptor subunit driving the association is unclear. Recent work in mice has highlighted a possible role for variants in the Gabr β1 subunit (Gabrβ1) in alcohol dependence risk, although this gene does not contain any common nonsynonymous variants in humans. However, the GABAA receptor is a heteropentamer so multiple potential variants within the gene complex could generate the alcohol dependence phenotype. The association between GABRβ1 variants and alcohol dependence risk was explored in ...
Source: Psychiatric Genetics - May 3, 2017 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant
We report on two dizygotic twins with an MECP2-related psychiatric disorder without intellectual disability. Neuropsychological and psychiatric phenotype assessments were performed, and a genetic analysis was carried out. Both patients fulfilled the Pervasive Developmental Disorder criteria on Autism Diagnostic Observation Schedule and Asperger syndrome criteria on Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV). One patient developed early-onset schizophrenia (DSM-IV criteria) with two acute psychotic episodes, the latest one following corticosteroids and sodium valproate intake, with major hyperam...
Source: Psychiatric Genetics - May 3, 2017 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Common variants in SLC6A2, SLC6A3, DRD2, and major depressive disorder: an association study in the Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 3, 2017 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research

Further evidence for genetic variation at the serotonin transporter gene SLC6A4 contributing toward anxiety
Conclusion: Our results provide further evidence for an involvement of the serotonin transporter gene SLC6A4 in the etiology of anxiety-related traits. Furthermore, our study implicates that genetic variation at the genome-wide associated bipolar disorder locus ANK3 might influence anxiety-related personality traits. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 3, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls
Conclusion: Our study suggests that the potential of progranulin as a biomarker for bipolar disorder is genotype dependent. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 3, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research