Genetic analysis of common variants in the ZNF804A gene with schizophrenia and major depressive disorder
Conclusions
We found that rs12476147 (P=0.0078) was associated significantly with schizophrenia, but no SNPs showed statistically significant associations with major depressive disorder after Bonferroni correction. Moreover, we also found that haplotype block 2, which included rs12476147 and rs1344706, was associated significantly with schizophrenia and major depressive disorder. Nevertheless, we could not replicate the association of rs1344706 with schizophrenia. In conclusion, the common variant rs12476147 and the related haplotype block in ZNF804A were associated significantly with schizophrenia in the Han Chinese pop...
Source: Psychiatric Genetics - January 17, 2018 Category: Genetics & Stem Cells Tags: Original Article Source Type: research
Lack of association between triggering receptor expressed on myeloid cells 2 polymorphism rs75932628 and late-onset Alzheimer’s disease in a Chinese Han population
We examined 786 patients and 803 controls in this study. The rs75932628 polymorphism was evaluated using high-resolution melting analysis and direct sequencing. rs75932628-T (predicted to cause an R47H substitution) was absent in our cohort. We did not find an association between the rs75932628 single nucleotide polymorphism of TREM2 and LOAD in this study. Thus, rs75932628 is unlikely to be related to LOAD in the Chinese Han population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 2, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
Investigation of differential HDAC4 methylation patterns in eating disorders
The objective of this study was to investigate the relationship between methylation patterns of the histone deacetylase 4 gene and eating disorders in a site previously associated with anorexia nervosa (AN). Women with AN (N=28) or bulimia nervosa (BN) (N=19) were age-matched and sex-matched to controls (N=45). We obtained saliva-derived DNA and use bisulfite pyrosequencing to examine region-specific methylation differences between cases and controls. The region assayed includes 15 CpGs. We found no significant association between the previously implicated CpG and either AN or BN. We found that three CpGs were nominally as...
Source: Psychiatric Genetics - January 2, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
Association study of FGF18 with developmental dyslexia in Chinese population
Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools. However, we did not observe any single nucleotide polymorphism exceed...
Source: Psychiatric Genetics - January 2, 2018 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
Genetic analysis of common variants in the ZNF804A gene with schizophrenia and major depressive disorder
Conclusions
We found that rs12476147 (P=0.0078) was associated significantly with schizophrenia, but no SNPs showed statistically significant associations with major depressive disorder after Bonferroni correction. Moreover, we also found that haplotype block 2, which included rs12476147 and rs1344706, was associated significantly with schizophrenia and major depressive disorder. Nevertheless, we could not replicate the association of rs1344706 with schizophrenia. In conclusion, the common variant rs12476147 and the related haplotype block in ZNF804A were associated significantly with schizophrenia in the Han Chinese pop...
Source: Psychiatric Genetics - January 2, 2018 Category: Genetics & Stem Cells Tags: Original Article Source Type: research
ANK3 gene polymorphisms and bipolar disorder: a meta-analysis
Conclusion: The current meta-analysis provides corroborating evidence suggesting two ANK3 SNPs are associated with an increased susceptibility for developing BD. However, broader coverage is needed on less explored SNPs to further elucidate the genetic effect of other ANK3 variants that may harbor potential BD risk. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 27, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Multiple tissue methylation analysis of HTR2A exon I in suicidal behavior
Objective: The main aim of the current study was to investigate epigenetic alterations in serotonin 2A receptor (HTR2A) exon I CpG sites as possible risk factors for suicidal behavior. We also aimed to analyze the epigenetic alterations in two different tissues as epigenetic mechanisms are tissue specific. These epigenetic changes may lead to a better prediction of suicidal behavior.
Methods: Direct CpG methylation analysis was carried out on genomic DNA from the saliva of 20 schizophrenia suicide attempters and 27 non-attempters, and from post-mortem brain tissues of nine suicide victims and 11 controls. We used bisulfit...
Source: Psychiatric Genetics - October 27, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Genetic variants of increased waist circumference in psychosis
We examined whether established metabolic risk genetic variants in the population confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders and also an association with schizophrenia spectrum disorders irrespective of waist circumference.
Patients and methods: We analyzed the association in (i) a case–case model in which patients with schizophrenia spectrum disorder with increased waist circumference (≥80 cm for women and ≥94 cm for men) (n=534) were compared with patients with normal waist circumference ( (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - October 27, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
The role of the Cys23Ser (rs6318) polymorphism of the HTR2C gene in suicidal behavior: systematic review and meta-analysis
The polymorphisms of the serotonin receptor 2C (HTR2C) gene have been proposed to influence suicidal behavior. The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. The search was performed using EBSCO and PubMed databases. To be included in the analysis, the studies had to evaluate suicidal behavior (attempted, ideation, or completed suicide). The results of the meta-analysis were expressed as odds ratios (ORs). Because HTR2C lies on chromosome X, pooled ORs were calculated, respectively, for each of ...
Source: Psychiatric Genetics - October 27, 2017 Category: Genetics & Stem Cells Tags: Review Article Source Type: research
Lack of association between COMT Val158Met and ZDHHC8 rs175174 polymorphisms and susceptibility to schizophrenia in a Brazilian population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research
Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist
Major depression disorder (MDD) is a complex neuropsychiatric disorder and an increasing number of genetic risk variants are being identified. Investigation of their influence in the general population requires accurate and efficient assessment of depressive symptoms. Here, clinical interviews conducted by clinicians are the gold standard. We investigated whether valid and reliable clinical phenotypes can be obtained efficiently using self-administered instruments. Lifetime depressive symptoms and lifetime MDD diagnosis were assessed in 464 population-based individuals using a clinical interview and a structured, self-admi...
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes
Conclusion: These findings indicate that TPH1, TPH2, and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred
Conclusion: Our findings add to the growing evidence of genetic risk factors that act pleiotropically to increase the risk for several neuropsychiatric disorders, including depression and SA, irrespective of ancestry. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Longitudinal changes of associations between the preproghrelin Leu72Met polymorphism with depression in Chinese Han adolescents after the Wenchuan earthquake
Conclusion: These results suggest that the 72Met allele of the preproghrelin Leu72Met polymorphism may be associated with rehabilitation of depression in male Chinese Han adolescents after the natural disaster. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 30, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 6, 2017 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research
