Measuring how genetic and epigenetic variants can filter emotion perception
Emotion perception has been extensively studied in cognitive neurosciences and stands as a promising intermediate phenotype of social cognitive processes and psychopathologies. Exciting imaging genetic studies have recently identified genetic and epigenetic variants affecting brain responses during emotion perception tasks, but characterizing how these variants interact and relate to higher-order cognitive processes remains a challenge. Here, we integrate works in parallel fields and propose a new psychophysical conceptualization to address this issue. This approach proposes to consider genetic variants as ‘filters’ of...
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Commentary Source Type: research

Low-activity alleles of the MAOA gene are associated with measures of hostility
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Genetic association of the oxytocin receptor genes with panic, major depressive disorder, and social anxiety disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Association study between reward dependence and a functional BDNF polymorphism in adult women offspring of alcohol-dependent probands
Thirty-five healthy adult women offspring of alcohol-dependent probands (AWOA) were compared with 63 healthy controls to test whether personality dimensions on the Temperament and Character Inventory questionnaire were associated with the brain-derived neurotrophic factor Val66Met polymorphism in offspring. We found a significantly lower reward dependence score in AWOA compared with the controls. The brain-derived neurotrophic factor Val66Met polymorphism may be involved in this difference as the lower reward dependence score was found only in AWOA carrying the Val allele. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

The Met allele of BDNF Val66Met polymorphism is associated with increased BDNF levels in generalized anxiety disorder
Conclusion: These results suggest that BDNF could be involved in the neurobiology of GAD and might represent a useful marker associated with the disease. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Increases in multiple psychiatric disorders in parents and grandparents of patients with bipolar disorder from the USA compared with The Netherlands and Germany
Conclusion: The increased complexity of psychiatric illness and its occurrence over several generations in the families of patients with bipolar disorder from the USA versus Europe could be contributing to the higher incidence of childhood onsets and greater virulence of illness in the USA compared with Europe. These data are convergent with others suggesting increased both genetic and environmental risk in the USA, but require replication in epidemiologically-derived populations with data based on interviews of the family members. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system
Substance use disorders have significant personal, familial, and societal consequences. Despite the serious consequences of substance use, only a few therapies are effective in treating substance use disorders, thus highlighting a need for improved treatment practices. Substance use treatment response depends on multiple factors such as genetic, biological, and social factors. It is essential that each component is represented in treatment plans. The dopaminergic system plays a critical role in the pharmacotherapy for addictions, and an understanding of the role of variation of genes involved in this system is essential fo...
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

Promoter polymorphism of the serotonin transporter gene influences the number of sexual partners and smoking habits in a Mexican Mestizo population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 26, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research

Association of the HTR2A 102T/C polymorphism with attempted suicide: a meta-analysis
An association between the serotonin 2A receptor (5-HT2A receptor) gene and suicidal behavior has been reported in many studies. However, no consistent conclusion has been reached. One potential reason for this is heterogeneity in the studies analyzed, which may have been caused by the selection of different types of cases and controls. In the present study, we pooled data from the previous published papers to clarify the association between HTR2A 102T/C and attempted suicide. All case–control studies written in English and published up until 20 November 2013 were selected. The history of suicide attempts and other relev...
Source: Psychiatric Genetics - June 26, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

CACNA1C gene and schizophrenia: a case–control and pharmacogenetic study
Conclusions: Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ. Further, five SNPs were associated with improvement in PANSS subscales, suggesting a role for this gene in antipsychotic response as well. However, taking into account the limitations of the present study, further research is needed to confirm our findings. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 26, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Different genetic factors underlie fear conditioning and episodic memory
Conclusion: Individual differences in fear conditioning and episodic memory reflect distinct genetically influenced processes, suggesting that the genetic risk for learning-induced anxiety disorders includes at least two memory-related genetic factors. These findings are consistent with the facts that the two separate learning forms are distant in their evolutionary development, involve different brain mechanisms, and support that genetically independent memory systems are pivotal in the development and maintenance of syndromes related to fear learning. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 26, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Effects of genetic variations in NRG1 on cognitive domains in patients with schizophrenia and healthy individuals
Conclusion: This study suggests the involvement of NRG1 in the susceptibility for developing cognitive deficits in schizophrenic patients. For some cognitive domains, its genetic effect was also significant in generating interindividual variability within the normal functional range. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 26, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

A genome-wide association study of late-onset Alzheimer’s disease in a Japanese population
Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - June 26, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Sex, age and smoking, but not genetic variation in LEPR (rs1137101), are associated with depressive symptoms
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research