Ethnicity-dependent effects of Zinc finger 804A variant on schizophrenia: a systematic review and meta-analysis
Conclusions Our findings suggested that the risk of single nucleotide polymorphism rs1344706 A-allele may increase the risk of schizophrenia worldwide. Also, this ethnicity-dependent effects of ZNF804A variant on schizophrenia may be related to the opposite allele direction. But to elucidate the underlying biological mechanism, further studies with large participant populations are needed. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 27, 2021 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses
Conclusion Further exploitation of the use of qualitative trait analysis in GWAS in ADS is warranted. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 27, 2021 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Epigenetics in bipolar disorder: a critical review of the literature
Conclusion Epigenetic is a growing and promising field in BD that may shed light on its pathophysiology or be useful as biomarkers of response to mood-stabilizer. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 27, 2021 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

A genetic window to auditory-verbal problems in bipolar disorder
Bipolar disorder is a high prevalent psychiatric condition entailing recurrent episodes of elevated mood and depression, but also diverse cognitive problems. One deficit observed in patients concerns to auditory-verbal processing. Being a hereditary condition with a complex genetic architecture, it is not clear which genes contribute to this deficit. We show that candidates for bipolar disorder significantly overlap with candidates for clinical conditions resulting from a deficit in the phonological loop of working memory, particularly, developmental dyslexia and specific language impairment. The overlapping genes are invo...
Source: Psychiatric Genetics - November 14, 2020 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Genetic impact of ZNF804A on cognitive function in patients with bipolar I disorder
Our previous genetic study identified a variant rs1344706 in the zinc finger protein 804A (ZNF804A) gene conferring susceptibility to bipolar disorder subtype I (BD-I) in Han Chinese. Literature documented that this variant may affect brain structure and function. As such, we attempted to identify whether the rs1344706 polymorphism influences cognitive function in patients with bipolar disorder I. We recruited 177 patients with bipolar disorder in remission period. Cognitive function was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The single nucleotide polymorphisms (SNP)...
Source: Psychiatric Genetics - November 14, 2020 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

LRP8 (rs5177) and CEP85L (rs11756438) are contributed to schizophrenia susceptibility in Iranian population
Conclusion In rs11756438, the AA genotype was associated with disease susceptibility, while allele A did not have a significant association with the disease. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - November 14, 2020 Category: Genetics & Stem Cells Tags: Original Article Source Type: research

The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review
Succinic semialdehyde dehydrogenase (SSADH) deficiency is an ultra-rare inborn error of metabolism that results in disrupted gamma-amino butyric acid (GABA) catabolism. In addition to developmental delay, intellectual disability, hypotonia, ataxia, and seizures, a variety of neuropsychiatric symptoms may occur, including psychosis. By highlighting all available and relevant case reports/series, this qualitative review seeks to characterize the prevalence, clinical manifestation, pathophysiology, and treatment of psychotic symptoms in this population. Psychosis occurs in a minority of SSADH-deficient individuals, and most c...
Source: Psychiatric Genetics - November 14, 2020 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

Do damaging variants of SLC6A9, the gene for the glycine transporter 1 (GlyT-1), protect against schizophrenia?
The aim of the investigation was to test whether genetic variants predicted to impair the functionality of SLC6A9, which codes for the GlyT-1 glycine transporter, are protective against schizophrenia. In an exome sequenced sample of 4225 schizophrenia cases and 5834 controls, variants occurring in SLC6A9 were annotated and weights were assigned using GENEVARASSOC. Genotype counts were compared using SCOREASSOC. Variants predicted to be deleterious by SIFT and damaging by PolyPhen were examined. Genotypes at 1:44466494-G/A seemed likely to be erroneous. If these were ignored then there were 15 damaging variants in controls ...
Source: Psychiatric Genetics - September 14, 2020 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population
In this study, we aimed to investigate the association between PTN polymorphisms and schizophrenia in an independent case-control sample-set including 738 schizophrenia patients and 1085 healthy controls. Of the 13 selected single nucleotide polymorphisms (SNPs), five showed significant differences in allele or/and genotype frequencies between patients and controls: rs3959914 (genotype: χ2 = 11.5217, P = 0.0032); rs11765480 (genotype: χ2 = 10.6620, P = 0.0049); rs1473355 (genotype: χ2 = 8.3902, P = 0.0151); rs322246 (allele: χ2 = 5.5954, P = 0.0180); rs322240 (genotype: χ2 = 8.8429, P = 0.0121; allele: χ2 = 8.7802, P...
Source: Psychiatric Genetics - September 14, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Understanding the clinical manifestations of 16p11.2 deletion syndrome: a series of developmental case reports in children
Conclusion This variation in clinical phenotype renders correct clinical interpretation and diagnosis challenging. Therefore, it is critical to elucidate the variable clinical phenotypes of rare CNVs, including 16p11.2 deletions, to help guide clinical monitoring and counselling of patients and families. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - September 14, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects
Objective The aim of the study is to test the association of a functional variant each in DRD2 and COMT genes with schizophrenia and its endophenotypes. Basic methods Effect of two functional variants rs1076560 in DRD2 and rs4680 in COMT on (1) schizophrenia (502 cases, 448 controls) diagnosed by Diagnostic and Statistical Manual of Mental Disorders-IV criteria and in subsets with (2) tardive dyskinesia (80 positive, 103 negative), assessed by Abnormal Involuntary Movement Scale (AIMS), positive and negative symptoms assessed by Positive and Negative Syndrome Scale (PANSS) and (3) cognition (299 cases, 245 controls), ...
Source: Psychiatric Genetics - September 14, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Paroxysmal oculogyric dystonia associated with a de novo 3q29 microdeletion
This report describes a young adult female with 3q29 deletion syndrome, autism spectrum disorder, intellectual disability, and anxiety who experienced a sustained, non-medication induced paroxysmal oculogyric dystonia which responded to anticholinergic and antihistaminic medications. This is the first report of paroxysmal oculogyric dystonia associated with this deletion, possibly expanding the phenotypic features of this microdeletion syndrome. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 30, 2020 Category: Genetics & Stem Cells Tags: Brief Report Source Type: research

The genetic variations in SAP97 gene and the risk of schizophrenia in the Chinese Han population: a further study
Conclusion Our data are further to indicate that the SAP97 gene polymorphisms may affect neurocognitive function especially verbal memory and the first to suggest that the SAP97 rs9843659 polymorphism may influence abstract thinking of schizophrenic patients in the southern Han Chinese population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 30, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis
Conclusions: NET G1287A polymorphisms are involved in the etiology of MDD and antidepressant response. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - July 30, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The role of the gut microbiota in the pathophysiology of mental and neurological disorders
In recent decades, the concept of the gut microbiota as a potential novel therapeutic strategy for mental health has emerged. The tiny microbes inhabiting our gut communicate through a bidirectional communication signaling with the brain that influences gut physiology, brain function and behavior. Accumulating evidence suggests that perturbation of the gut microbiota contributes to the pathophysiology of mental illnesses including autism, depression and anxiety as well as neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. This review will highlight recent findings in both human and animal studies...
Source: Psychiatric Genetics - July 30, 2020 Category: Genetics & Stem Cells Tags: Review Article Source Type: research