Association of GRIN1, ABCB1, and DRD4 genes and response to antipsychotic drug treatment in schizophrenia
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letters Source Type: research

Catechol-O-methyltransferase genotype and response to Compensatory Cognitive Training in outpatients with schizophrenia
This study aimed to explore the contribution of COMT genotype in predicting improvement following Compensatory Cognitive Training (CCT). We conducted mixed factorial analysis of variance to examine COMT genotype as a predictor of response to CCT (i.e. improved cognitive performance) in 41 participants with schizophrenia-spectrum disorders. We also explored the effect of CCT treatment and COMT genotype on psychiatric symptom severity, functional capacity, and subjective quality of life. Met carrier status did not predict CCT treatment outcomes. COMT genotype may exert only modest effects on cognitive training response. Furt...
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Adolescent perspectives on the return of individual results in genomic addiction research
This study surveyed all adolescents who were enrolled in behavioral genomic research and provided DNA to a biobank, including 320 patients undergoing treatment for substance and conduct problems (SCPs) and 109 non-SCP controls. Participants selected from three options on the return of individual genomic results (RIR) and rated eight methods of re-contact. Most individuals with SCPs (77.8%) and non-SCP controls (72.5%) wanted RIR involving health or behavioral implications. The majority of individuals with SCPs (67.2%) and non-SCP controls (69.7%) indicated that phone re-contact was ‘best’, with e-mail (22.5% SCPs, 33.9...
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research

Association between the dopamine transporter gene (DAT1) and attention deficit hyperactivity disorder-related traits in healthy adults
Conclusion: Our study results suggest that DAT1 polymorphisms may modulate mood instability traits in the normal population. Considering that mood instability tends to persist through the entire course of ADHD and is highly prevalent in many diseases that are comorbid with ADHD, this trait may be a core endophenotype that defines the role of the DAT1 gene in various psychiatric conditions. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Tic symptom dimensions and their heritabilities in Tourette’s syndrome
Conclusion: These findings suggest that (i) three tic factors can be discerned with a distinct underlying genetic architecture and that (ii) considering the low tic heritabilities found, only focusing on the narrow-sense TS phenotype and leaving out comorbidities that are part of the broader sense tic phenotype may lead to missing heritability. Although these findings need replication in larger independent samples, they might have consequences for future genetic studies in TS. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder
Conclusion: Our findings suggest that further work and larger sample sizes are required to elucidate the link between early childhood abuse and the HPA axis in suicidal behavior. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias
Conclusion: An association of the NR3C2 gene and childhood trauma with negative memory bias was found in depressed patients in remission, which extends previous findings in a healthy population. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Lack of genetic association between the MYO9B locus and schizophrenia in a Chinese population
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Letter to the Editor Source Type: research

Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Brief Association Letter Source Type: research

Olanzapine-induced DNA methylation in the hippocampus and cerebellum in genes mapped to human 22q11 and implicated in schizophrenia
Background: Although there is indirect evidence that the effects of antipsychotic drugs may involve modulation of dopamine transmission, their mechanism of action is poorly understood. We hypothesized that antipsychotic drugs mediate their effects by epigenetic modulation. Here, we tested the effect of an antipsychotic, olanzapine, on the DNA methylation status of genes following chronic treatment using rat-specific methylation arrays. Methods: Forty-eight hours after the last dose of olanzapine/vehicle, rats were habituated to an open-field activity-monitoring chamber for 30 min to verify whether stress-induced locomoto...
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Active ribosomal genes, translational homeostasis and oxidative stress in the pathogenesis of schizophrenia and autism
Discussion: Our findings confirm the hypothesis of disturbance of the ‘translational homeostasis’ in the pathogeneses of autism and schizophrenia, and would help explain why oxidative stress markers are discovered in most autism studies, whereas similar reports related to schizophrenia are far less consistent. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes
Conclusion: This study provides novel insight into the relationship between anxiety, epigenetics and IL-6. Moreover, our findings support the hypothesis that changes in DNA methylation profiles may contribute to the biology of anxiety. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Copy number variants in attention-deficit hyperactive disorder: identification of the 15q13 deletion and its functional role
Conclusion: Our findings are consistent with the presence of 15q13 deletions in Italian ADHD patients. More interestingly, we show that pathways related to immune/inflammatory response and oxidative stress signaling are affected by the deletion of KFL13 and CHRNA7. Because the phenotypic effects of 15q13 are pleiotropic, our findings suggest that there are shared biologic pathways among multiple neuropsychiatric conditions. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

A meta-analysis of the associations between the SLC6A4 promoter polymorphism (5HTTLPR) and the risk for alcohol dependence
Serotonin reuptake variation is linked to a functional polymorphism in the promoter region of the SLC6A4 gene on chromosome 17. It is plausible that variations in genetically determined SLC6A4 activity may modify the risk for alcohol dependence. To determine whether this allele is associated with alcohol dependence, the authors conducted a systematic review and meta-analysis. Twenty-five studies including 8885 participants were reviewed and analyzed. The meta-analysis was carried out using a random-effects model. Overall, the results did not support an association between alcohol dependence and the SLC6A4 promoter polymorp...
Source: Psychiatric Genetics - February 27, 2015 Category: Genetics & Stem Cells Tags: Review Article Source Type: research

Summaries of oral sessions at the XXI World Congress of Psychiatric Genetics, Boston, Massachusetts, 17–21 October 2013: state of the field: Erratum
No abstract available (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - January 6, 2015 Category: Genetics & Stem Cells Tags: Erratum Source Type: research