Analysis of differential membrane proteins related to matrix stiffness-mediated metformin resistance in hepatocellular carcinoma cells
Our previous work shows that increased matrix stiffness not only alters malignant characteristics of hepatocellular carcinoma (HCC) cells, but also attenuates metformin efficacy in treating HCC cells. Here, we... (Source: Proteome Science)
Source: Proteome Science - September 22, 2023 Category: Bioinformatics Authors: Xiangyu Gao, Jiali Qian, Yang Zhang, Heming Wang, Jiefeng Cui and Yehong Yang Tags: Research Source Type: research
PRM-based quantitative proteomics analysis of altered HSP abundance in villi and decidua of patients with early missed abortion
In this study, we aimed to identify differentially expressed heat shock protein (HSP) profiles in the villi and decidua from patients with early missed abortion (EMA). (Source: Proteome Science)
Source: Proteome Science - August 16, 2023 Category: Bioinformatics Authors: Xiao-Fang Chen, Xiao-Qing Chen, Hai-Lian Luo, Li-Na Xia, Shu-Hui Huang and Qi Chen Tags: Research Source Type: research
Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D
Effective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and rupture risk assessment of AA can provide insights into medical therapy and ... (Source: Proteome Science)
Source: Proteome Science - August 5, 2023 Category: Bioinformatics Authors: Yusuke Murakami, Mitsuhiro Nishigori, Hiroaki Yagi, Tsukasa Osaki, Masaki Wakabayashi, Manabu Shirai, Cheol Son, Yutaka Iba, Kenji Minatoya, Kengo Kusano, Tsutomu Tomita, Hatsue Ishibashi-Ueda, Hitoshi Matsuda and Naoto Minamino Tags: Research Source Type: research
Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study
Subarachnoid haemorrhage (SAH) is one of the most severe forms of stroke in which delayed cerebral ischemia is one of the major complications. Neurointensive care aims at preventing and treating such complicat... (Source: Proteome Science)
Source: Proteome Science - July 7, 2023 Category: Bioinformatics Authors: Fredrik Ginstman, Bijar Ghafouri and Peter Zsigmond Tags: Research Source Type: research
Data-independent acquisition-based mass spectrometry(DIA-MS) for quantitative analysis of patients with chronic hepatitis B
Chronic hepatitis B is a significant public health problem and complex pathologic process, and unraveling the underlying mechanisms and pathophysiology is of great significance. Data independent acquisition ma... (Source: Proteome Science)
Source: Proteome Science - June 6, 2023 Category: Bioinformatics Authors: Bo Wang, Qian Zhang, Lili Wu, Cunliang Deng, Meiyan Luo, Yu Xie, Gang Wu, Wen Chen, Yunjian Sheng, Peng Zhu and Gang Qin Tags: Research Source Type: research
Purification and proteomic analysis of potent fibrinolytic enzymes extracted from Lumbricus rubellus
Lumbrokinase derived from earthworms, Lumbricus rubellus is known to have fibrinolytic enzymes that have potential as therapeutic drugs due to its ability to dissolve fibrin. The current study is aimed to purify ... (Source: Proteome Science)
Source: Proteome Science - May 8, 2023 Category: Bioinformatics Authors: Laurentia Stephani, Puji Rahayu, Debbie Retnoningrum, Maggy Thenawidjaja Suhartono, Heni Rachmawati and Raymond R. Tjandrawinata Tags: Research Source Type: research
Proteomics identifies differentially expressed proteins in glioblastoma U87 cells treated with hederagenin
We investigated differentially expressed proteins (DEPs) in human glioblastoma U87 cells after treatment with hederagenin as a therapeutic screening mechanism and provided a theoretical basis for hederagenin i... (Source: Proteome Science)
Source: Proteome Science - April 29, 2023 Category: Bioinformatics Authors: Yesen Zhang, Yi Han, Yuchun Shang, Xiangyu Wang and Jiwei Sun Tags: Research Source Type: research
Proteomics profiling for the global and acetylated proteins of papillary thyroid cancers
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy cancer among the malignancies of thyroid. Despite of wide usages of proteomics in PTC, the profile of acetylated proteins in PTC remain... (Source: Proteome Science)
Source: Proteome Science - April 26, 2023 Category: Bioinformatics Authors: Wei Wei, Yuezhang Wu, Dong-Dong Chen, Yuntao Song, Guohui Xu, Qi Shi and Xiao-Ping Dong Tags: Research Source Type: research
Effects of Atractylodes lancea extracts on intestinal flora and serum metabolites in mice with intestinal dysbacteriosis
This study aims to explore the effect of an extract of Atractylodes lancea (A. lancea) on antibiotics-induced intestinal tract disorder and the probable therapeutic mechanisms employed by this extract to ameliora... (Source: Proteome Science)
Source: Proteome Science - April 15, 2023 Category: Bioinformatics Authors: BaiNian Zhang, Lan Bu, Hui Tian, ZhangQiang You, MingHai Zhao, Jie Tian, YuanYuan Zhang, Qian Wang, ChengJia Tan, Yu Cao, DaRen Feng and ZhenPeng Xi Tags: Research Source Type: research
Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus
Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses. Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating... (Source: Proteome Science)
Source: Proteome Science - April 11, 2023 Category: Bioinformatics Authors: Wenrui Fu, Zifeng Xie, Mei Bai, Zhen Zhang, Yuanlong Zhao and Jing Tian Tags: Research Source Type: research
Isolation and proteomic profiling of urinary exosomes from patients with colorectal cancer
Exosomes in the body fluid are effective cell-derived membranous structures transferring various molecules to mediate intercellular communication. The expression of protein in the urinary exosomes from the col... (Source: Proteome Science)
Source: Proteome Science - February 9, 2023 Category: Bioinformatics Authors: Ling Ma, Haijiao Yu, Yubing Zhu, Kaiyu Xu, Aimin Zhao, Lei Ding, Hong Gao and Man Zhang Tags: Research Source Type: research
Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
This study aims to decode the proteomic signature of cardiomyocytes in response to lncRNA Ftx knockdown and overexpression via proteomic analysis, and to study the biological role of lncRNA Ftx in cardiomyocyt... (Source: Proteome Science)
Source: Proteome Science - January 5, 2023 Category: Bioinformatics Authors: Xiangfei Sun, Ying Jiang, Qingbao Li, Qi Tan, Mingliang Dong, Bi ’e Cai, Di Zhang and Qi Zhao Tags: Research Source Type: research
Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells
Dl-3-n-butylphthalide (NBP) is an important medial therapy for acute ischemic stroke in China. Recent studied have revealed that NBP not only rescued the loss of dopaminergic neurons in cellular and animal mod... (Source: Proteome Science)
Source: Proteome Science - January 3, 2023 Category: Bioinformatics Authors: Yuan Zhao, Jian Zhang, Yidan Zhang, Shuyue Li, Ya Gao, Cui Chang, Xiang Liu, Lei Xu and Guofeng Yang Tags: Research Source Type: research
Responses of the tree peony (Paeonia suffruticosa, Paeoniaceae) cultivar ‘Yu Hong’ to heat stress revealed by iTRAQ-based quantitative proteomics
Horticulture productivity has been increasingly restricted by heat stress from growing global warming, making it far below the optimum production capacity. As a popular ornamental cultivar of tree peony, Paeonia ... (Source: Proteome Science)
Source: Proteome Science - December 29, 2022 Category: Bioinformatics Authors: Jin Ma, Qun Wang, Ling-Ling Wei, Yu Zhao, Guo-Zhe Zhang, Jie Wang and Cui-Hua Gu Tags: Research Source Type: research
TMT-based quantitative proteomics analysis of the effects of Jiawei Danshen decoction myocardial ischemia-reperfusion injury
Every year, approximately 17 million people worldwide die due to coronary heart disease, with China ranking second in terms of the death toll. Myocardial ischemia-reperfusion injury (MIRI) significantly influe... (Source: Proteome Science)
Source: Proteome Science - December 14, 2022 Category: Bioinformatics Authors: Xiang-Mei Zhu, Yang Tan, Yu-He Shi, Qing Li, Jue Zhu, Xiang-Dan Liu and Qiao-Zhen Tong Tags: Research Source Type: research
