One-dimensional proteomic profiling of Danio rerio embryo vitellogenin to estimate quantum dot toxicity
Conclusion:
This study demonstrates the possible utility of Vtg profiling in D. rerio embryos as a sensitive diagnostic tool to estimate nanoparticle toxicity. (Source: Proteome Science)
Source: Proteome Science - May 2, 2015 Category: Bioinformatics Authors: Natalia PetushkovaGalina KuznetsovaOlesya LarinaYulia KisrievaNatalia SamenkovaOxana TrifonovaYuliana MiroshnichenkoKonstantin ZolotarevIrina KaruzinaOlga IpatovaAndrey Lisitsa Source Type: research
Label-free quantitative phosphorylation analysis of human transgelin2 in Jurkat T cells reveals distinct phosphorylation patterns under PKA and PKC activation conditions
Conclusions:
Multiple actin-binding regions of transgelin2 participate to accomplish its full actin-binding capability, and the actin-binding affinity of each actin-binding region appears to be modulated by specific kinase-dependent phosphorylation changes. Accordingly, different actin-binding properties or cellular functions of transgelin2 may result from distinct intracellular signalling events under immune response activation or homeostasis conditions. (Source: Proteome Science)
Source: Proteome Science - March 26, 2015 Category: Bioinformatics Authors: Se JangChang-Duk JunZee-Yong Park Source Type: research
Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain
Conclusions:
Dopamine signalling modes via D1/D5 receptors in the auditory cortex differentially impact protein profiles related to rearrangement of cytomatrices, energy metabolism, and synaptic neurotransmission in cortical, hippocampal, and basal brain structures. Altered dopamine neurotransmission in α-synuclein-deficient mice revealed that distinct D1/D5 receptor signalling modes may control different aspects of memory consolidation. (Source: Proteome Science)
Source: Proteome Science - March 18, 2015 Category: Bioinformatics Authors: Nicole ReichenbachUlrike HerrmannThilo KähneHorst SchicknickRainer PielotMichael NaumannDaniela DieterichEckart GundelfingerKarl-Heinz SmallaWolfgang Tischmeyer Source Type: research
A preliminary quantitative proteomic analysis of glioblastoma pseudoprogression
Conclusions:
The results of the present study both revealed the biological signatures of PsPD from a proteomics perspective and indicated that CDH2 alone or combined with ELAVL1 could be potential biomarkers with high accuracy in the diagnosis of PsPD. (Source: Proteome Science)
Source: Proteome Science - March 12, 2015 Category: Bioinformatics Authors: Peng ZhangZhengguang GuoYang ZhangZhixian GaoNan JiDanqi WangLili ZouWei SunLiwei Zhang Source Type: research
New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing
Conclusions:
This study provides new insights into Nek4 functions, identifying new interaction partners and further suggests an interesting difference between isoform 1 and isoform 2 of this kinase. Nek4 isoform 1 may have similar roles compared to other Neks and these roles are not all preserved in isoform 2. Besides, in some processes, both isoforms showed opposite effects, indicating a possible fine controlled regulation. (Source: Proteome Science)
Source: Proteome Science - February 26, 2015 Category: Bioinformatics Authors: Fernanda BaseiGabriela MeirellesGermanna RighettoDeivid dos Santos MigueletiJuliana SmetanaJörg Kobarg Source Type: research
Towards further defining the proteome of mouse saliva
Conclusions:
The present study is the most comprehensive list to date of the proteins that constitute the mouse salivary proteome. The data presented can serve as a useful resource for identifying potentially useful biomarkers of human health and disease. (Source: Proteome Science)
Source: Proteome Science - February 25, 2015 Category: Bioinformatics Authors: Anne BlanchardPeyman EzzatiDmitry ShamshurinAndreea NistorEtienne LeygueJohn WilkinsYvonne Myal Source Type: research
Proteome changes in the small intestinal mucosa of broilers ( Gallus gallus ) induced by high concentrations of atmospheric ammonia
Conclusions:
These findings have important implications for understanding the toxic mechanisms of ammonia on intestine of broilers, which provides new information that can be used for intervention using nutritional strategies in the future. (Source: Proteome Science)
Source: Proteome Science - February 21, 2015 Category: Bioinformatics Authors: Jize ZhangCong LiXiangfang TangQingping LuRenna SaHongfu Zhang Source Type: research
The proteome profiles of the olfactory bulb of juvenile, adult and aged rats - an ontogenetic study
Conclusion:
In this study, quantitative changes in the expression of proteins in the oB at different developmental stages (postnatal days (P) 7, 90 and 637) could be observed. Furthermore, the expression of many proteins was found at specific developmental stages. It was possible to identify these proteins which are involved in processes like support of cell migration and differentiation. (Source: Proteome Science)
Source: Proteome Science - February 15, 2015 Category: Bioinformatics Authors: Michael WilleAntje SchümannMichael KreutzerMichael GlockerAndreas WreeGrit MutzbauerOliver Schmitt Source Type: research
Proteomic characterization of adrenal gland embryonic development reveals early initiation of steroid metabolism and reduction of the retinoic acid pathway
Conclusions:
This study presents the first comprehensive wide proteome analysis of three different stages of embryonic adrenal gland development. The identified proteins, which were expressed in early stages of development, will shed light on the molecular mechanisms underlying embryonic development of the adrenal gland. (Source: Proteome Science)
Source: Proteome Science - February 7, 2015 Category: Bioinformatics Authors: Gry DihaziGerhard MuellerAbdul AsifMarwa EltoweissyJohannes WesselsHassan Dihazi Source Type: research
Examination of the skeletal proteome of the brittle star Ophiocoma wendtii reveals overall conservation of proteins but variation in spicule matrix proteins
Conclusions:
Our results show an overall conservation of the types of proteins found in the mineralized tissues of two divergent groups of echinoderms, as well as in mineralized tissues in general. However, the extensive gene duplication and concerted evolution seen in the spicule matrix proteins found in the sea urchin skeleton was not observed in the brittle star. (Source: Proteome Science)
Source: Proteome Science - February 7, 2015 Category: Bioinformatics Authors: Ryan SeaverBrian Livingston Source Type: research
Proteome changes induced by Pyrenophora tritici-repentis ToxA in both insensitive and sensitive wheat indicate senescence-like signaling
Conclusion:
This is the first report of a biochemical response in an insensitive cultivar in this plant-pathogen interaction. Findings support the involvement of ethylene, and the activation of complementary pathways in sensitive versus insensitive wheat cultivars responding to Ptr ToxA. The nature of the system permits using purified toxin to mimic disease, which eliminates the pathogen proteome and ensures a synchronous response in inoculated leaves. (Source: Proteome Science)
Source: Proteome Science - February 5, 2015 Category: Bioinformatics Authors: Jacqueline DayRoman GietzChristof Rampitsch Source Type: research
Interaction of peroxiredoxin V with dihydrolipoamide branched chain transacylase E2 (DBT) in mouse kidney under hypoxia
Conclusions:
We identified several proteins interacting with Prdx V under hypoxic condition known to induce renal oxidative stress. In hypoxic condition, we observed an enhanced interaction of Prdx V and DBT protein as well as increased DBT enzymatic activity. The results from this study will contribute to enhance our understanding of Prdx V?s role in hypoxic stress and may suggest new directions for future research. (Source: Proteome Science)
Source: Proteome Science - February 5, 2015 Category: Bioinformatics Authors: Sun AhnHee-Young YangGia TranJoseph KwonKyu-Yeol SonSuhee KimQuoc DinhSeunggon JungHa-Mi LeeKyoung-Oh ChoTae-Hoon Lee Source Type: research
Selection of a protein solubilization method suitable for phytopathogenic bacteria: a proteomics approach
Conclusions:
These results attest to the adequacy of these proteins extraction methods for proteomic studies. (Source: Proteome Science)
Source: Proteome Science - February 5, 2015 Category: Bioinformatics Authors: Carolina MalafaiaMyrzânia GuerraTúlio SilvaPatrícia PaivaElineide SouzaMaria CorreiaMárcia Silva Source Type: research
Proteomics analysis of urine reveals acute phase response proteins as candidate diagnostic biomarkers for prostate cancer
In this study, we focused on identification of non-invasive biomarkers in urine with higher specificity than PSA. We tested urine samples from PCa and benign prostatic hyperplasia (BPH) patients by 2-D DIGE coupled with MS and bioinformatics analysis. Statistically significant (p? (Source: Proteome Science)
Source: Proteome Science - January 29, 2015 Category: Bioinformatics Authors: Katarina DavalievaSanja KiprijanovskaSelim KominaGordana PetrusevskaNatasha ZografskaMomir Polenakovic Source Type: research
Comparative proteomics analysis of differential proteins in respond to doxorubicin resistance in myelogenous leukemia cell lines
Conclusions:
As a whole, under the chemical stress, the doxorubicin-resistant myelogenous leukemia cells may employ various protective strategies to survive. These include: (i) pumping the cytotoxic drug out of the cells by P-glycoprotein, (ii) increased storage of fermentable fuel, (iii) sophisticated cellular protection by molecular chaperones, (iv) improved handling of intracellular calcium, (v) increased glucose utilization via increased rates of glycolysis. In the present study, proteomic analysis of leukemia cells and their drug resistant variants revealed multiple alterations in protein expression. Our results indic...
Source: Proteome Science - January 22, 2015 Category: Bioinformatics Authors: Shi QinghongGao ShenSong LinaZhao YuemingLi XiaoouWu JianlinHe ChengyanLi HongjunZhao Haifeng Source Type: research
