Effects of mycophenolate mofetil on kidney function and phosphorylation status of renal proteins in Alport COL4A3-deficient mice
Conclusions:
These data suggest that the MMF treatment in this murine model moderately improved kidney function and reversed the phosphorylation status of six renal phosphoprotein spots to that seen in WT mice. (Source: Proteome Science)
Source: Proteome Science - December 10, 2014 Category: Bioinformatics Authors: Darinka PetrovaFrank SchultzeGunnar BrandhorstKlaus-Dieter LuchsChristof LenzHenning UrlaubDiana RubelOliver GrossPhilip WalsonMichael Oellerich Source Type: research
Proteomic analysis of seed storage proteins in wild rice species of the Oryza genus
Conclusion:
This was the first report on proteomic analysis of the three wild rice species. Overall results suggest that there were many new types of glutelin subunits and precursor in the three wild rice species. Hence, wild rice species are important genetic resources for improving nutritional quality to rice. (Source: Proteome Science)
Source: Proteome Science - November 30, 2014 Category: Bioinformatics Authors: Chunmiao JiangZaiquan ChengCheng ZhangTengqiong YuQiaofang ZhongJ ShenXingqi Huang Source Type: research
New insights in the composition of extracellular vesicles from pancreatic cancer cells: implications for biomarkers and functions
Conclusion:
The data deepen the knowledge of extracellular vesicle composition by hundreds of proteins that have not been previously described as vesicle components released by pancreatic cancer cells. Extracellular vesicles derived from pancreatic cancer cells show common proteins shared with other vesicles as well as cell type specific proteins indicating biomarker candidates and suggesting functional roles in cancer cell stroma interactions. (Source: Proteome Science)
Source: Proteome Science - November 18, 2014 Category: Bioinformatics Authors: Susanne Klein-ScoryMahnaz TehraniChristina Eilert-MicusKamila AdamczykNathalie WojtalewiczMartina SchnölzerStephan HahnWolff SchmiegelIrmgard Schwarte-Waldhoff Source Type: research
Promoter trapping method: transcription factor purification using human telomerase reverse transcriptase promoter
Conclusion:
Here we focus on verifying the ability and versatility of Promoter Trapping coupled with additional well-characterized methods to identify already known factors responsible for telomerase transcriptional regulation. (Source: Proteome Science)
Source: Proteome Science - November 18, 2014 Category: Bioinformatics Authors: Linda NagoreYanWen ZhouRobert NadeauYinShan JiaHarry Jarrett Source Type: research
Unravelling associations between unassigned mass spectrometry peaks with frequent itemset mining techniques
Conclusions:
This simple approach offers opportunities to monitor accumulating unexplained mass spectrometry data for emerging new patterns, with possible applications for the development of mass exclusion lists, for the refinement of quality control strategies and for a further interpretation of unexplained spectral peaks in mass spectrometry and tandem mass spectrometry. (Source: Proteome Science)
Source: Proteome Science - November 18, 2014 Category: Bioinformatics Authors: Trung VuAida MrzicDirk ValkenborgEvelyne MaesFilip LemièreBart GoethalsKris Laukens Source Type: research
Proteomic analysis of rat cartilage: the identification of differentially expressed proteins in the early stages of osteoarthritis
Conclusions:
The proteins that we identified indicate that energy metabolism, cartilage matrix remodelling, and protective cellular mechanisms are associated with early OA. In addition, latexin expression during the early stages of OA is implicated in cartilage repair. (Source: Proteome Science)
Source: Proteome Science - November 18, 2014 Category: Bioinformatics Authors: Nancy Parra-TorresFebe Cázares-RagaJuan Kouri Source Type: research
Mass Spectrometric Immunoassay for the qualitative and quantitative analysis of the cytokine Macrophage Migration Inhibitory Factor (MIF)
Conclusions:
The quantitative MIF MSIA assay provides a sensitive, precise and high throughput method to delineate and quantify MIF proteoforms in biological samples. (Source: Proteome Science)
Source: Proteome Science - October 14, 2014 Category: Bioinformatics Authors: Nisha ShermaChad BorgesOlgica TrenchevskaJason JarvisDouglas RehderPaul OranRandall NelsonDobrin Nedelkov Source Type: research
The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome
Conclusions:
We purpose the severity of hypoxia as the cornerstone for explaining the differences observed between both groups. (Source: Proteome Science)
Source: Proteome Science - October 10, 2014 Category: Bioinformatics Authors: Carlos LabordeSergio Alonso-OrgazLaura Mourino-AlvarezJosé MoreuFernando VivancoLuis PadialMaría Barderas Source Type: research
Impact of three commercial feed formulations on farmed gilthead sea bream ( Sparus aurata, L. ) metabolism as inferred from liver and blood serum proteomics
Conclusions:
This study highlights the contribution of proteomics for understanding and improving the metabolic compatibility of feeds for marine aquaculture, and opens new perspectives for its monitoring with serological tests. (Source: Proteome Science)
Source: Proteome Science - September 24, 2014 Category: Bioinformatics Authors: Stefania GhisauraRoberto AneddaDaniela PagnozziGrazia BiosaSimona SpadaElia BonagliniRoberto CappuccinelliTonina RoggioSergio UzzauMaria Addis Source Type: research
Potential serum biomarkers for glioblastoma diagnostic assessed by proteomic approaches
Conclusions:
Proteomic technologies have been used to investigate the protein profile of glioblastoma patients and established several potential diagnostic biomarkers. While it is unlikely for a single biomarker to be highly effective for glioblastoma diagnostic, our data proposed an alternative and efficient approach by using a novel combination of multiple biomarkers. (Source: Proteome Science)
Source: Proteome Science - September 24, 2014 Category: Bioinformatics Authors: Ionela PopescuElena CodriciLucian AlbulescuSimona MihaiAna-Maria EnciuRadu AlbulescuCristiana Tanase Source Type: research
Comparative proteomics and glycoproteomics of plasma proteins in Indian visceral leishmaniasis
Conclusions:
These proteins may be involved in the survival of parasites, resisting neutrophil elastase, and in their multiplication in macrophages, potentially maintaining endogenous anti-inflammatory and immunosuppressive conditions. Consequently, the results of this study may help in understanding the host response against L.donovani, which could help in the discovery of new drugs and disease management. Finally, these alterations on protein levels might be beneficial in improving early diagnosis considering those as biomarkers in Indian VL. (Source: Proteome Science)
Source: Proteome Science - September 22, 2014 Category: Bioinformatics Authors: Arup BagSutapa SahaShyam SundarBibhuti SahaAbhijit ChakrabartiChitra Mandal Source Type: research
Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia
Conclusions:
We speculate the five peptides, FGA, isoform 1 of fibrinogen alpha chain precursor, GSTP1, PF4 and connective tissue active peptide III would be potential biomarkers for forecasting relapse, monitoring MRD and evaluating therapeutic response in adult ALL. (Source: Proteome Science)
Source: Proteome Science - September 16, 2014 Category: Bioinformatics Authors: Ju BaiAili HeChen HuangJuan YangWanggang ZhangJianli WangYun YangPengyu ZhangYang ZhangFuling Zhou Source Type: research
Proteomic study of sporadic inclusion body myositis
Conclusions:
Our study reveals a unique pattern of protein expression in s-IBM, which should be further investigated in a wider cohort of IBM patients to fully realize the potential diagnostic or therapeutic benefits. (Source: Proteome Science)
Source: Proteome Science - September 12, 2014 Category: Bioinformatics Authors: Ke LiChuanqiang PuXusheng HuangJiexiao LiuYanling MaoXianghui Lu Source Type: research
Two dimensional gel phosphoproteome of peripheral blood mononuclear cells: comparison between two enrichment methods
Conclusion:
Our results describe the differences and the validity of phosphoprotein enrichment methods and provide two successful and complementary approaches for the 2DE phosphoproteome analysis of PBMCs. (Source: Proteome Science)
Source: Proteome Science - September 9, 2014 Category: Bioinformatics Authors: Maria RocchettiMichela AlfaranoLeonarda VarrasoSalvatore Di PaoloMassimo PapaleElena RanieriGiuseppe GrandalianoLoreto Gesualdo Source Type: research
Probing SH2-domains using Inhibitor Affinity Purification (IAP)
Conclusion:
The results make this probe a promising starting point for the development of a mixed affinity resin with complete SH2 protein coverage. Moreover, the additional findings render it a valuable tool for the evaluation of PI3K complex interrupting inhibitors. (Source: Proteome Science)
Source: Proteome Science - July 16, 2014 Category: Bioinformatics Authors: Michael HöfenerStephanie HeinzlmeirBernhard KusterNorbert Sewald Source Type: research
