DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines
Protein Cell. 2023 Jun 28;14(7):532-537. doi: 10.1093/procel/pwac028.NO ABSTRACTPMID:37378658 | DOI:10.1093/procel/pwac028 (Source: Protein and Cell)
Source: Protein and Cell - June 28, 2023 Category: Cytology Authors: Ya-Hui Zhao Wei Jiang Hai Gao Guo-Zheng Pang Yu-Shuang Wu Yuan-Xian Wang Meng-Yao Sheng Jia-Ying Xie Wan-Ling Wu Zhi-Jian Ji Ya-Rui Du Lei Zhang Xiao-Qin Wang Colum P Walsh Hai Jiang Guo-Liang Xu Dan Zhou Source Type: research
An engineered xCas12i with high activity, high specificity, and broad PAM range
Protein Cell. 2023 Jun 28;14(7):538-543. doi: 10.1093/procel/pwac052.NO ABSTRACTPMID:37378659 | DOI:10.1093/procel/pwac052 (Source: Protein and Cell)
Source: Protein and Cell - June 28, 2023 Category: Cytology Authors: Hainan Zhang Xiangfeng Kong Mingxing Xue Jing Hu Zikang Wang Yinghui Wei Haoqiang Wang Jingxing Zhou Weihong Zhang Mengqiu Xu Xiaowen Shen Fengcai Yin Zhiyuan Ai Guangyan Huang Junhui Xia Xueqiong Song Hengbin Li Yuan Yuan Jinhui Li Na Zhong Meiling Zhang Source Type: research
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
This study expands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases.PMID:37378670 | DOI:10.1093/procel/pwad039 (Source: Protein and Cell)
Source: Protein and Cell - June 28, 2023 Category: Cytology Authors: Shanshan Yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng Yiyuan Zhang Shuhui Sun Kang Wang Jian Yin Shuai Ma Si Wang Juan Carlos Izpisua Belmonte Weiqi Zhang Jing Qu Guang-Hui Liu Source Type: research
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids
Protein Cell. 2023 Jun 22:pwad038. doi: 10.1093/procel/pwad038. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be addressed. Here, we established human CRC tumor-derived organoids that well represent both morphological and molecular heterogeneities of original tumors. To efficiently identify repurposed drugs for CRC, we developed a robust organoid-based drug screening system. By combining the repurposed drug library and computation-based drug prediction, 335 drugs were tested and 34 drugs with anti-CRC effects ...
Source: Protein and Cell - June 22, 2023 Category: Cytology Authors: Yunuo Mao Wei Wang Jingwei Yang Xin Zhou Yongqu Lu Junpeng Gao Xiao Wang Lu Wen Wei Fu Fuchou Tang Source Type: research
