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Applications of genetic code expansion technology in eukaryotes
Protein Cell. 2023 Oct 17:pwad051. doi: 10.1093/procel/pwad051. Online ahead of print.ABSTRACTUnnatural amino acids (UAAs) have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to proteins. In eukaryotes, genetic code expansion (GCE) enables the incorporation of UAAs and facilitates posttranscriptional modification (PTM), which is not feasible in prokaryotic systems. GCE is also a powerful tool for cell or animal imaging, the monitoring of protein interactions in target cells, drug development, and switch regulation. Therefore, there i...
Source: Protein and Cell - October 17, 2023 Category: Cytology Authors: Qiao-Ru Guo Yu J Cao Source Type: research