Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets
We describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers respectively. In addition, we highlight the relationship between microbiota and the therapeutic efficacy, toxicity, or side effects of commonly utilized treatments for cancer, including chemotherapy, radiotherapy, and immunotherapy. Given that microbial factors influence the cancer treatment outcome, we further summarize some dominating microbial interventions and discuss the hidden risks of these strategies. This review aims to provide an overview of the application and advancements of microbes in cancer clinical rel...
Source: Protein and Cell - November 10, 2023 Category: Cytology Authors: Jia-Hao Dai Xi-Rong Tan Han Qiao Na Liu Source Type: research
Anthrax lethal toxin and tumor necrosis factor- α synergize on intestinal epithelia to induce mouse death
Protein Cell. 2023 Oct 19:pwad050. doi: 10.1093/procel/pwad050. Online ahead of print.ABSTRACTBacillus anthracis (B. anthracis) lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system. The interplay between LT and the host responses is important in the pathogenesis, but our knowledge on this interplay remains limited. Tumor necrosis factor-α (TNF) is a pleiotropic pro-inflammatory cytokine induced by bacterial infections. Since LT accumulates and cytokines, predominantly TNF, ama...
Source: Protein and Cell - October 19, 2023 Category: Cytology Authors: Xinhe Gao Teng Teng Yifei Liu Tingting Ai Rui Zhao Yilong Fu Peipei Zhang Jiahuai Han Yingying Zhang Source Type: research
