Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy
Protein Cell. 2024 Mar 5:pwae006. doi: 10.1093/procel/pwae006. Online ahead of print.ABSTRACTThe current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) remains a threat to pregnant women. However, the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood. Here, we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy. Compared to control placentas, SARS-CoV-2 infection elicited immune responses at the maternal-fe...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiao Xiao Han Li Wu Xiaohui Shi Zhiyi Hu Ming Tang Zhongqu Su Yingdong Liu Binya Liu Jiqing Yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu Source Type: research

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
Protein Cell. 2024 Mar 5:pwae007. doi: 10.1093/procel/pwae007. Online ahead of print.ABSTRACTIntensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within the receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein lead to the functional alteration in both receptor engagement and monoclonal antibody (mAb) recognition. Here, we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune evasio...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Song Xue Yuru Han Fan Wu Qiao Wang Source Type: research

Skeletal stem cells in bone development, homeostasis and disease
Protein Cell. 2024 Mar 5:pwae008. doi: 10.1093/procel/pwae008. Online ahead of print.ABSTRACTTissue-resident stem cells are essential for development and repair, and in the skeleton this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells. Recent studies have utilized techniques such as fluorescence-activated cell sorting (FACS), lineage tracing and single-cell sequencing to investigate the involvement of SSCs in bone development, homeostasis and disea...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Guixin Yuan Xixi Lin Ying Liu Matthew B Greenblatt Ren Xu Source Type: research

Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy
Protein Cell. 2024 Mar 5:pwae006. doi: 10.1093/procel/pwae006. Online ahead of print.ABSTRACTThe current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) remains a threat to pregnant women. However, the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood. Here, we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy. Compared to control placentas, SARS-CoV-2 infection elicited immune responses at the maternal-fe...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiao Xiao Han Li Wu Xiaohui Shi Zhiyi Hu Ming Tang Zhongqu Su Yingdong Liu Binya Liu Jiqing Yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu Source Type: research

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
Protein Cell. 2024 Mar 5:pwae007. doi: 10.1093/procel/pwae007. Online ahead of print.ABSTRACTIntensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within the receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein lead to the functional alteration in both receptor engagement and monoclonal antibody (mAb) recognition. Here, we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune evasio...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Song Xue Yuru Han Fan Wu Qiao Wang Source Type: research

Skeletal stem cells in bone development, homeostasis and disease
Protein Cell. 2024 Mar 5:pwae008. doi: 10.1093/procel/pwae008. Online ahead of print.ABSTRACTTissue-resident stem cells are essential for development and repair, and in the skeleton this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells. Recent studies have utilized techniques such as fluorescence-activated cell sorting (FACS), lineage tracing and single-cell sequencing to investigate the involvement of SSCs in bone development, homeostasis and disea...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Guixin Yuan Xixi Lin Ying Liu Matthew B Greenblatt Ren Xu Source Type: research

Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy
Protein Cell. 2024 Mar 5:pwae006. doi: 10.1093/procel/pwae006. Online ahead of print.ABSTRACTThe current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) remains a threat to pregnant women. However, the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood. Here, we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy. Compared to control placentas, SARS-CoV-2 infection elicited immune responses at the maternal-fe...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiao Xiao Han Li Wu Xiaohui Shi Zhiyi Hu Ming Tang Zhongqu Su Yingdong Liu Binya Liu Jiqing Yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu Source Type: research

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
Protein Cell. 2024 Mar 5:pwae007. doi: 10.1093/procel/pwae007. Online ahead of print.ABSTRACTIntensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within the receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein lead to the functional alteration in both receptor engagement and monoclonal antibody (mAb) recognition. Here, we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune evasio...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Song Xue Yuru Han Fan Wu Qiao Wang Source Type: research

Skeletal stem cells in bone development, homeostasis and disease
Protein Cell. 2024 Mar 5:pwae008. doi: 10.1093/procel/pwae008. Online ahead of print.ABSTRACTTissue-resident stem cells are essential for development and repair, and in the skeleton this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells. Recent studies have utilized techniques such as fluorescence-activated cell sorting (FACS), lineage tracing and single-cell sequencing to investigate the involvement of SSCs in bone development, homeostasis and disea...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Guixin Yuan Xixi Lin Ying Liu Matthew B Greenblatt Ren Xu Source Type: research

Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy
Protein Cell. 2024 Mar 5:pwae006. doi: 10.1093/procel/pwae006. Online ahead of print.ABSTRACTThe current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) remains a threat to pregnant women. However, the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood. Here, we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy. Compared to control placentas, SARS-CoV-2 infection elicited immune responses at the maternal-fe...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiao Xiao Han Li Wu Xiaohui Shi Zhiyi Hu Ming Tang Zhongqu Su Yingdong Liu Binya Liu Jiqing Yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu Source Type: research

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
Protein Cell. 2024 Mar 5:pwae007. doi: 10.1093/procel/pwae007. Online ahead of print.ABSTRACTIntensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within the receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein lead to the functional alteration in both receptor engagement and monoclonal antibody (mAb) recognition. Here, we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune evasio...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Song Xue Yuru Han Fan Wu Qiao Wang Source Type: research

Skeletal stem cells in bone development, homeostasis and disease
Protein Cell. 2024 Mar 5:pwae008. doi: 10.1093/procel/pwae008. Online ahead of print.ABSTRACTTissue-resident stem cells are essential for development and repair, and in the skeleton this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells. Recent studies have utilized techniques such as fluorescence-activated cell sorting (FACS), lineage tracing and single-cell sequencing to investigate the involvement of SSCs in bone development, homeostasis and disea...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Guixin Yuan Xixi Lin Ying Liu Matthew B Greenblatt Ren Xu Source Type: research

Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy
Protein Cell. 2024 Mar 5:pwae006. doi: 10.1093/procel/pwae006. Online ahead of print.ABSTRACTThe current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) remains a threat to pregnant women. However, the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood. Here, we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy. Compared to control placentas, SARS-CoV-2 infection elicited immune responses at the maternal-fe...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiao Xiao Han Li Wu Xiaohui Shi Zhiyi Hu Ming Tang Zhongqu Su Yingdong Liu Binya Liu Jiqing Yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu Source Type: research

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
Protein Cell. 2024 Mar 5:pwae007. doi: 10.1093/procel/pwae007. Online ahead of print.ABSTRACTIntensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within the receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein lead to the functional alteration in both receptor engagement and monoclonal antibody (mAb) recognition. Here, we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune evasio...
Source: Protein and Cell - March 5, 2024 Category: Cytology Authors: Song Xue Yuru Han Fan Wu Qiao Wang Source Type: research