Long-term in vivo chimeric cells tracking in non-human primate
Protein Cell. 2023 Sep 27:pwad049. doi: 10.1093/procel/pwad049. Online ahead of print.ABSTRACTNon-human primates (NHP) are increasingly used in preclinical trials to test the safety and efficacy of biotechnology therapies. Nonetheless, given the ethical issues and costs associated with this model, it would be highly advantageous to use NHP cellular models in clinical studies. However, developing and maintaining the naïve state of primate pluripotent stem cells (PSCs) remains difficult as does in vivo detection of PSCs, thus limiting biotechnology application in the cynomolgus monkey. Here, we report a chemically defined, ...
Source: Protein and Cell - September 27, 2023 Category: Cytology Authors: Junmo Wu Yu Kang Xiang Luo Shaoxing Dai Yuxi Shi Zhuoyao Li Zengli Tang Zhenzhen Chen Ran Zhu Pengpeng Yang Zifan Li Hong Wang Xinglong Chen Ziyi Zhao Weizhi Ji Yuyu Niu Source Type: research
