Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing
Protein Cell. 2023 Dec 8:pwad058. doi: 10.1093/procel/pwad058. Online ahead of print.NO ABSTRACTPMID:38066594 | DOI:10.1093/procel/pwad058 (Source: Protein and Cell)
Source: Protein and Cell - December 9, 2023 Category: Cytology Authors: Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S Chepurwar Regina C élia Mingroni Netto Karina Lezirovitz Alfredo Tabith Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobi Source Type: research
Long way up: rethink diseases in light of phase separation and phase transition
Protein Cell. 2023 Dec 9:pwad057. doi: 10.1093/procel/pwad057. Online ahead of print.ABSTRACTBiomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a trans...
Source: Protein and Cell - December 9, 2023 Category: Cytology Authors: Mingrui Ding Weifan Xu Gaofeng Pei Pilong Li Source Type: research
Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing
Protein Cell. 2023 Dec 8:pwad058. doi: 10.1093/procel/pwad058. Online ahead of print.NO ABSTRACTPMID:38066594 | DOI:10.1093/procel/pwad058 (Source: Protein and Cell)
Source: Protein and Cell - December 9, 2023 Category: Cytology Authors: Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S Chepurwar Regina C élia Mingroni Netto Karina Lezirovitz Alfredo Tabith Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobi Source Type: research
Long way up: rethink diseases in light of phase separation and phase transition
Protein Cell. 2023 Dec 9:pwad057. doi: 10.1093/procel/pwad057. Online ahead of print.ABSTRACTBiomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a trans...
Source: Protein and Cell - December 9, 2023 Category: Cytology Authors: Mingrui Ding Weifan Xu Gaofeng Pei Pilong Li Source Type: research
Correction to: Low-dose chloroquine treatment extends the lifespan of aged rats
Protein Cell. 2023 Dec 4:pwad053. doi: 10.1093/procel/pwad053. Online ahead of print.NO ABSTRACTPMID:38048445 | DOI:10.1093/procel/pwad053 (Source: Protein and Cell)
Source: Protein and Cell - December 4, 2023 Category: Cytology Source Type: research
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice
Protein Cell. 2023 Nov 27:pwad056. doi: 10.1093/procel/pwad056. Online ahead of print.ABSTRACTSporadic or late-onset Alzheimer's disease (LOAD) accounts for more than 95% of AD cases without any family history. Although genome-wide association studies (GWAS) have identified associated risk genes and loci for LOAD, numerous studies suggest that many adverse environmental factors, such as social isolation, are associated with an increased risk of dementia. However, the underlying mechanisms of social isolation in AD progression remain elusive. In the current study, we found that 7 days of social isolation could trigger patte...
Source: Protein and Cell - November 27, 2023 Category: Cytology Authors: He-Zhou Huang Wen-Qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu Chao-Wen Zhou Man-Fei Deng Wen-Tao Zhang Jia-Chen Zhang Chun-Qing Yang Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan Guo Yo Source Type: research
ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader
Protein Cell. 2023 Nov 22:pwad054. doi: 10.1093/procel/pwad054. Online ahead of print.ABSTRACTTelomeres are specialized structures at the ends of linear chromosomes that protect genome stability. The telomeric repeat-containing RNA (TERRA) that is transcribed from subtelomeric regions can invade into double-stranded DNA regions and form RNA:DNA hybrid-containing structure called R-loop. In tumor cells, R-loop formation is closely linked to gene expression and the alternative lengthening of telomeres (ALT) pathway. Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are re...
Source: Protein and Cell - November 22, 2023 Category: Cytology Authors: Chuanle Wang Yan Huang Yue Yang Ruofei Li Yingying Li Hongxin Qiu Jiali Wu Guang Shi Wenbin Ma Zhou Songyang Source Type: research
