The ubiquitin codes in cellular stress responses
Protein Cell. 2023 Jul 20:pwad045. doi: 10.1093/procel/pwad045. Online ahead of print.ABSTRACTUbiquitination/ubiquitylation, one of the most fundamental post-translational modifications (PTMs), regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquit...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Xiangpeng Sheng Zhixiong Xia Hanting Yang Ronggui Hu Source Type: research

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Protein Cell. 2023 Jul 20:pwad040. doi: 10.1093/procel/pwad040. Online ahead of print.ABSTRACTContinual evolution of the SARS-CoV-2 virus has allowed for its gradual evasion of neutralizing antibodies (nAbs) produced in response to natural infection or vaccination. The rapid nature of these changes has incited a need for the development of superior broad nAbs and/or the rational design of an antibody cocktail that can protect against the mutated virus strain. Here, we report two ACE2 competing nAbs-8H12 and 3E2-with synergistic neutralization but evaded by some Omicron subvariants. Cryo-EM reveals the two nAbs synergistic ...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zh Source Type: research

Radiation injury and gut microbiota-based treatment
This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.PMID:37470727 | DOI:10.1093/procel/pwad044 (Source: Protein and Cell)
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Weihong Wang Bota Cui Yongzhan Nie Lijuan Sun Faming Zhang Source Type: research

The ubiquitin codes in cellular stress responses
Protein Cell. 2023 Jul 20:pwad045. doi: 10.1093/procel/pwad045. Online ahead of print.ABSTRACTUbiquitination/ubiquitylation, one of the most fundamental post-translational modifications (PTMs), regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquit...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Xiangpeng Sheng Zhixiong Xia Hanting Yang Ronggui Hu Source Type: research

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Protein Cell. 2023 Jul 20:pwad040. doi: 10.1093/procel/pwad040. Online ahead of print.ABSTRACTContinual evolution of the SARS-CoV-2 virus has allowed for its gradual evasion of neutralizing antibodies (nAbs) produced in response to natural infection or vaccination. The rapid nature of these changes has incited a need for the development of superior broad nAbs and/or the rational design of an antibody cocktail that can protect against the mutated virus strain. Here, we report two ACE2 competing nAbs-8H12 and 3E2-with synergistic neutralization but evaded by some Omicron subvariants. Cryo-EM reveals the two nAbs synergistic ...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zh Source Type: research

Radiation injury and gut microbiota-based treatment
This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.PMID:37470727 | DOI:10.1093/procel/pwad044 (Source: Protein and Cell)
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Weihong Wang Bota Cui Yongzhan Nie Lijuan Sun Faming Zhang Source Type: research

The ubiquitin codes in cellular stress responses
Protein Cell. 2023 Jul 20:pwad045. doi: 10.1093/procel/pwad045. Online ahead of print.ABSTRACTUbiquitination/ubiquitylation, one of the most fundamental post-translational modifications (PTMs), regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquit...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Xiangpeng Sheng Zhixiong Xia Hanting Yang Ronggui Hu Source Type: research

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Protein Cell. 2023 Jul 20:pwad040. doi: 10.1093/procel/pwad040. Online ahead of print.ABSTRACTContinual evolution of the SARS-CoV-2 virus has allowed for its gradual evasion of neutralizing antibodies (nAbs) produced in response to natural infection or vaccination. The rapid nature of these changes has incited a need for the development of superior broad nAbs and/or the rational design of an antibody cocktail that can protect against the mutated virus strain. Here, we report two ACE2 competing nAbs-8H12 and 3E2-with synergistic neutralization but evaded by some Omicron subvariants. Cryo-EM reveals the two nAbs synergistic ...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zh Source Type: research

Radiation injury and gut microbiota-based treatment
This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.PMID:37470727 | DOI:10.1093/procel/pwad044 (Source: Protein and Cell)
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Weihong Wang Bota Cui Yongzhan Nie Lijuan Sun Faming Zhang Source Type: research

The ubiquitin codes in cellular stress responses
Protein Cell. 2023 Jul 20:pwad045. doi: 10.1093/procel/pwad045. Online ahead of print.ABSTRACTUbiquitination/ubiquitylation, one of the most fundamental post-translational modifications (PTMs), regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquit...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Xiangpeng Sheng Zhixiong Xia Hanting Yang Ronggui Hu Source Type: research

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Protein Cell. 2023 Jul 20:pwad040. doi: 10.1093/procel/pwad040. Online ahead of print.ABSTRACTContinual evolution of the SARS-CoV-2 virus has allowed for its gradual evasion of neutralizing antibodies (nAbs) produced in response to natural infection or vaccination. The rapid nature of these changes has incited a need for the development of superior broad nAbs and/or the rational design of an antibody cocktail that can protect against the mutated virus strain. Here, we report two ACE2 competing nAbs-8H12 and 3E2-with synergistic neutralization but evaded by some Omicron subvariants. Cryo-EM reveals the two nAbs synergistic ...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zh Source Type: research

Radiation injury and gut microbiota-based treatment
This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.PMID:37470727 | DOI:10.1093/procel/pwad044 (Source: Protein and Cell)
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Weihong Wang Bota Cui Yongzhan Nie Lijuan Sun Faming Zhang Source Type: research

The ubiquitin codes in cellular stress responses
Protein Cell. 2023 Jul 20:pwad045. doi: 10.1093/procel/pwad045. Online ahead of print.ABSTRACTUbiquitination/ubiquitylation, one of the most fundamental post-translational modifications (PTMs), regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquit...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Xiangpeng Sheng Zhixiong Xia Hanting Yang Ronggui Hu Source Type: research

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Protein Cell. 2023 Jul 20:pwad040. doi: 10.1093/procel/pwad040. Online ahead of print.ABSTRACTContinual evolution of the SARS-CoV-2 virus has allowed for its gradual evasion of neutralizing antibodies (nAbs) produced in response to natural infection or vaccination. The rapid nature of these changes has incited a need for the development of superior broad nAbs and/or the rational design of an antibody cocktail that can protect against the mutated virus strain. Here, we report two ACE2 competing nAbs-8H12 and 3E2-with synergistic neutralization but evaded by some Omicron subvariants. Cryo-EM reveals the two nAbs synergistic ...
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zh Source Type: research

Radiation injury and gut microbiota-based treatment
This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.PMID:37470727 | DOI:10.1093/procel/pwad044 (Source: Protein and Cell)
Source: Protein and Cell - July 20, 2023 Category: Cytology Authors: Weihong Wang Bota Cui Yongzhan Nie Lijuan Sun Faming Zhang Source Type: research