Adenocarcinoma of the Uterine Cervix: Measuring, Staging, and Synoptic Reporting
Adenocarcinoma of the cervix is increasing in incidence in relative and real terms given the reduction in cervical squamous carcinomas in many developed countries. In this review, various aspects relating to the pathological staging of cervical carcinomas are discussed with emphasis on adenocarcinomas. These include the distinction between adenocarcinoma in situ and invasive lesions and the measurement of invasive adenocarcinomas; both of these issues are often more difficult than with the corresponding squamous lesions. The measurement of multifocal cervical carcinomas is covered with discussion of the International Colla...
Source: Pathology Case Reviews - March 1, 2018 Category: Pathology Tags: Reviews Source Type: research
Glandular Lesions of the Uterine Cervix: Cytology and Histology Updates
No abstract available (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - March 1, 2018 Category: Pathology Tags: Editorial Source Type: research
Benign Mixed Epithelial and Stromal Tumor of the Kidney With Cytogenetic Alterations—Advances and Controversies in Classification of Biphasic Cystic Renal Tumors
We present a case of benign mixed epithelial and stromal tumor of the kidney (MEST) with some unusual features, such as a partially exophytic growth, relatively solid tumor architecture, and negative stains for estrogen/progesterone receptors. We also report the results of cytogenetic studies and discuss the differential diagnosis of the MEST family of tumors in the context of other biphasic cystic renal lesions.
Based on the molecular studies thus far published, MEST and adult cystic nephroma are similar to each other but different from other kidney lesions, including morphologically similar cystic and biphasic pediatric...
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
Intra-Ampullary Papillary-Tubular Neoplasm: An Update on the Ampullary Counterparts of Pancreatobiliary Intraductal Neoplasms
Intra-ampullary papillary tubular neoplasms (IAPNs) are papillary or polypoid lesions that originate from and grow predominantly within the ampulla. They are fundamentally “adenoma-carcinoma sequence” and as such represent intra-ampullary counterparts of other tumoral intraepithelial neoplasms of the pancreatobiliary tract, namely, intraductal papillary mucinous neoplasms (of pancreas), intraductal papillary neoplasms (of bile ducts), intraductal tubulopapillary neoplasms (ITPNs) (of bile ducts and pancreas), and intracholecystic papillary tubular neoplasms (of gallbladder). Intra-ampullary papillary tubular neoplasm...
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
Ciliated Muconodular Papillary Tumor of the Lung: A New Entity Formerly Regarded as a Well-Differentiated Adenocarcinoma
We present a case of CMPT incidentally identified in a lung explant with emphysema; review the clinical, histopathologic, and molecular features of CMPT and its differential diagnosis; and explore the controversial aspects regarding diagnosis, origin, and classification of these neoplasms. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
NUT Midline Carcinoma: An Underdiagnosed and Often Misunderstood Entity
We present a case of presumed metastatic NUT midline carcinoma from our institution, as well as a review of NMC, focusing on clinical, histopathologic, and immunohistochemical features, and a brief discussion of the molecular aberrations characteristic of this entity. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
Clinicopathologic Features of Secretory Carcinoma of Salivary Gland: An Updated Review
We present a case of secretory carcinoma that was reclassified from cystadenocarcinoma using immunohistochemical and molecular testing and present an updated review of the clinicopathologic features with discussion of differential diagnosis. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
A Protein Lost, a Diagnosis Gained: A Review of SMARCB1-Deficient Sinonasal Carcinomas
In recent years, improved molecular techniques have allowed for extensive reclassification of sinonasal tumors, particularly those previously diagnosed as sinonasal undifferentiated carcinomas. SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1-deficient sinonasal carcinoma is one such recently described entity defined by loss of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1 (INI1) protein expression by immunohistochemistry. This review characterizes the clinical, histologic, molecular, and immunohistochemical features of thi...
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Review Source Type: research
Molecular Testing Uncovers an Adamantinoma-Like Ewing Family of Tumors in the Thyroid: Case Report and Review of Literature
We present a case of a malignant neoplasm of the thyroid showing epithelioid and basaloid nests with metastases to cervical lymph nodes and pancreas. This case was initially classified as a poorly differentiated thyroid carcinoma. Following an extended molecular analysis of the tumor, reverse transcriptase–polymerase chain reaction detected the hallmark EWSR:FLI1 gene fusion. This case was subsequently reclassified as adamantinoma-like EFT. In cases of basaloid or undifferentiated epithelioid tumors, the possibility of adamantinoma-like EFT should be included in a working differential diagnosis. Testing for CD99 and EWSR...
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
Noninvasive Follicular Neoplasm of Thyroid With Papillary Like Nuclear Features: A Redefined Indolent Neoplasm of the Thyroid Gland
Follicular variant of papillary thyroid carcinoma (FVPC) represents approximately 30% of all papillary thyroid carcinomas and includes encapsulated, both invasive and noninvasive forms (E-FVPC), and infiltrative FVPCs with different biological behaviors and molecular profiles. The E-FVPC exhibits very low regional recurrence and metastatic potential with a biological behavior similar to that of follicular adenomas.
In 2015, a panel of endocrine pathologists, endocrinologists, surgeons, and patient advocates recommended the revision of the diagnostic terminology for cases of noninvasive E-FVPC to rename them as “noninvas...
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Case Reviews Source Type: research
New Names for Old Entities—A Potpouri of Newly Defined Tumors
No abstract available (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2018 Category: Pathology Tags: Editorial Source Type: research
Benign Mixed Epithelial and Stromal Tumor of the Kidney With Cytogenetic Alterations—Advances and Controversies in Classification of Biphasic Cystic Renal Tumors
We present a case of benign mixed epithelial and stromal tumor of the kidney (MEST) with some unusual features, such as a partially exophytic growth, relatively solid tumor architecture, and negative stains for estrogen/progesterone receptors. We also report the results of cytogenetic studies and discuss the differential diagnosis of the MEST family of tumors in the context of other biphasic cystic renal lesions.
Based on the molecular studies thus far published, MEST and adult cystic nephroma are similar to each other but different from other kidney lesions, including morphologically similar cystic and biphasic pediatric...
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
Intra-Ampullary Papillary-Tubular Neoplasm: An Update on the Ampullary Counterparts of Pancreatobiliary Intraductal Neoplasms
Intra-ampullary papillary tubular neoplasms (IAPNs) are papillary or polypoid lesions that originate from and grow predominantly within the ampulla. They are fundamentally “adenoma-carcinoma sequence” and as such represent intra-ampullary counterparts of other tumoral intraepithelial neoplasms of the pancreatobiliary tract, namely, intraductal papillary mucinous neoplasms (of pancreas), intraductal papillary neoplasms (of bile ducts), intraductal tubulopapillary neoplasms (ITPNs) (of bile ducts and pancreas), and intracholecystic papillary tubular neoplasms (of gallbladder). Intra-ampullary papillary tubular neoplasm...
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
Ciliated Muconodular Papillary Tumor of the Lung: A New Entity Formerly Regarded as a Well-Differentiated Adenocarcinoma
We present a case of CMPT incidentally identified in a lung explant with emphysema; review the clinical, histopathologic, and molecular features of CMPT and its differential diagnosis; and explore the controversial aspects regarding diagnosis, origin, and classification of these neoplasms. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
NUT Midline Carcinoma: An Underdiagnosed and Often Misunderstood Entity
We present a case of presumed metastatic NUT midline carcinoma from our institution, as well as a review of NMC, focusing on clinical, histopathologic, and immunohistochemical features, and a brief discussion of the molecular aberrations characteristic of this entity. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
