Rectal Perivascular Epithelioid Cell Tumor With Partial CD117 Expression and Giant Cells
We present the case of a 62-year-old man with rectal PEComa with some unusual features, such as gastrointestinal stromal tumor–like CD117 positivity and HMB45 (human melanoma black-45)–positive multinucleated giant tumor cells. After 12 months' follow-up, the patient is alive with no radiologic, endoscopic, or histologic evidence of disease recurrence. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Congenital Benign Metastasizing Teratoma? A Case Report and Literature Review
A case is presented of a patient with completely resected congenital immature gastric teratoma containing yolk sac tumor, with locoregional recurrence and peritoneal seeding 25 months later as pure mature teratoma. To the knowledge of the author, this is the first case of its type to progress purely as mature teratoma. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Lights, Camera, CANCER: Principles of Macroscropic (Gross) Photography for Pathology Specimens
Gross photography is used both as a teaching tool for future health care workers and as a tool in a pathologist's diagnostic arsenal. Whereas gross descriptions can often be subjective and nonstandardized (and sometimes too convoluted in complex cases), photographs can play a final role in documentation. Where words might kindle an abstract imagination of a disease process, a photograph can capture both attention and understanding. There are 4 critical principles of good gross photography: (1) background surface, (2) photograph composition, (3) lighting, and (4) extra photography tools. As gross photography plays a pivotal...
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Reviews Source Type: research
Grossing Issues in Ovarian and Fallopian Tube Pathology
Ovaries and fallopian tubes are often removed for treatment of various benign and malignant gynecological conditions including prophylactic resections in high-risk patients. Meticulous grossing techniques are essential for staging, prognostication, and accurate diagnosis. We conducted a comprehensive review of published literature on methods for grossing pelvic adnexal specimens, including standard textbooks and grossing manuals, supplemented by a limited review of grossing protocols from academic institutions. This review addresses common issues encountered during the grossing of ovarian and fallopian tube specimens. (Sou...
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Reviews Source Type: research
Pancreatoduodenectomy: Perspectives on a Standardized Grossing Protocol for the Practicing Pathologist
The pancreatoduodenectomy or Whipple procedure is a complex oncologic surgical specimen with 2 dominant yet opposing standardized grossing protocols reported in the literature, the Leeds Pathology Protocol (LP) and the bivalving technique. The LP recommends the axial slicing of the pancreatic head perpendicular to the longitudinal axis of the duodenum, whereas the bivalving technique suggests sampling margins separately followed by bisecting the pancreas along the pancreatic and biliary ductal systems. An assessment can then be performed to determine which plane best serves to examine a particular tumor. This review provid...
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Reviews Source Type: research
The Head and Neck Oncology Specimen: The Gross Examination as an Essential Component to Diagnosis and Optimal Patient Outcomes
This article presents a review of recent publications and guidelines of general grossing principles and recent updates to optimize cancer-free surgical margins and to emphasize the limitation issues encountered in routine practice. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Reviews Source Type: research
Go Gross or Go Home: The Importance of Gross Examination in Lung Cancer Staging and Diagnosis of Nonneoplastic Diseases
Gross examination is fundamental to the practice of surgical pathology. Accurate diagnosis can often be made based on the classic gross appearance of a lung lesion. On the other hand, inaccurate diagnosis or wrong tumor staging is unavoidable if lesions are missed, unrecognized, or inadequately sampled. Different grossing techniques should be used for grossing neoplastic and nonneoplastic lung specimens. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Reviews Source Type: research
Grossing Breast Cancer Specimens: A Comprehensive Review
This article will provide a comprehensive source for grossing commonly received breast specimens, ranging from surgical biopsies to modified radical mastectomies and will describe the proper care of preanalytical measures to avoid compromise of biomarkers, methods to ensure adequate sampling of tissue for diagnosis, and assessment of tumor burden following neoadjuvant treatment. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Reviews Source Type: research
Evolving Grossing Techniques in Surgical Pathology
No abstract available (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - July 1, 2020 Category: Pathology Tags: Editorial Source Type: research
Blue Nevus of the Prostate: A Report of Two Cases and Review of the Literature
Pigmented lesions of the prostate are very rare and include melanosis, blue nevus, and malignant melanoma. Of these lesions, blue nevus (also known as pigmented melanocytosis or pigmentary nevohyperplasia) is the most frequently reported one. It is morphologically similar to its much more common cutaneous counterpart and composed mainly of heavily pigmented spindle cells within the prostatic stroma. It is often discovered incidentally in needle biopsies, transurethral resection of the prostate, or prostatectomy specimens performed for prostatic cancer or benign prostatic hyperplasia. It is a benign lesion with no potential...
Source: Pathology Case Reviews - May 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Prostatic Malakoplakia: Case Report and Review of the Literature
A 69-year-old Asian man with a history of overactive bladder presented with postvoid dribbling and urinary incontinence in the past three years. He had cervical spinal stenosis surgery one month ago and two episodes of urinary tract infections with multidrug-resistant Escherichia coli species in urine culture in the last three months. Digital rectal examination revealed a 1-cm hard nontender nodule within the right side of his prostate, concerning for possible prostatic malignancy. Ultrasound study identified a hypoechoic area in the right lateral prostate. Serum prostate-specific antigen level was 2.03 ng/mL (reference ra...
Source: Pathology Case Reviews - May 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Rhabdomyosarcoma of the Adult Prostate: Two Cases With Molecular and Cytogenetic Analyses
Primary rhabdomyosarcoma (RMS) of the adult prostate is a very rare tumor with only 45 cases published to date. The clinical course of RMS of the prostate is very aggressive, and prognosis is very poor. Here we describe two cases of primary RMS of the prostate of adult patients and discuss the differential diagnosis of RMS with other mesenchymal tumors of prostate. The first patient was a 50-year-old man who clinically presented with urinary retention and hematuria, low serum prostate-specific antigen, moderate prostatomegaly, and multiple metastases as shown by computed tomography. Histological examination revealed a diff...
Source: Pathology Case Reviews - May 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Prostatic Carcinoma With Aberrant Expression of p63: A Case Report and Review of the Literature
We report a case of prostatic carcinoma with aberrant expression of p63 with a review of the literature and helpful features in the differential diagnosis of this entity. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - May 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Histopathologic Changes in a Hypogonadal Male on Exogenous Testosterone Diagnosed With Prostatic Adenocarcinoma: A Case Report
In the United States, prostatic adenocarcinoma is the most common nonskin cancer and second leading cause of cancer death. Pathologic diagnostics are paramount to guiding treatment but require an awareness that hormonal treatments have the capacity to alter the histological appearance of prostate cancer. This case highlights the importance of accurate diagnostics and grading through a discussion of histological findings in an unusual case of a male patient with hypogonadism on long-term exogenous testosterone who was diagnosed with prostatic adenocarcinoma. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - May 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
Adenosquamous Carcinoma of the Prostate: A Unique Presentation of a Rare Entity and Review of the Literature
We describe a rare case of de novo metastatic adenosquamous carcinoma in a patient presenting with a markedly elevated serum prostate-specific antigen and multiple osteoblastic lesions. The prognosis for patients with adenosquamous carcinoma of the prostate has historically been dismal, with death occurring within 12 to 24 months of diagnosis. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - May 1, 2020 Category: Pathology Tags: Case Reviews Source Type: research
