Hot Topics in Appendiceal and Peritoneal Pathology
No abstract available (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - April 26, 2019 Category: Pathology Tags: Editorial Source Type: research
Ectopic Thymoma of the Right Atrium: A Case Report
We report a rare case of a right atrial ectopic thymoma. A 61-year-old woman presented with puffiness of face and shortness of breath. Cardiac computed tomography revealed a large right atrial mass with near-total occlusion of the chamber and extension into the superior vena cava and inflow tract of the right ventricle. She underwent resection of the right atrial mass. The final pathological diagnosis was intracardiac ectopic thymoma. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Case Reports Source Type: research
Endometrial Stromal Sarcoma With High-Grade Morphology and a JAZF1 Gene Rearrangement Presenting as Colonic and Cardiac Metastases: A Case Report and Review of the Literature
We report a case of an endometrial stromal sarcoma with a JAZF1 gene rearrangement by fluorescence in situ hybridization and high-grade cytology presenting as cardiac and colonic metastases, in a patient with a remote history of hysterectomy for to “leiomyomas.” (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Case Reports Source Type: research
Sarcomatoid Hepatocellular Carcinoma: A Case Report and Review of the Differential Diagnosis of Malignant Spindle Cell Lesions of the Liver
Sarcomatoid hepatocellular carcinoma is a rare aggressive variant of hepatocellular carcinoma that typically shows a conventional component of hepatocellular carcinoma admixed with a malignant spindle cell proliferation. In small biopsy specimens, the conventional component may not always be present; therefore, knowledge of the differential diagnosis of malignant spindle cell lesion presenting in the liver is necessary to ensure accurate diagnosis. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Case Reports Source Type: research
A Case of Small Cell Carcinoma With Adenocarcinoma Found in a Rectal Fissure
We present the case of a 51-year-old man with a history of pain with bowel movements and recent weight loss. Colonoscopy was performed, which revealed a rectal fissure with a lesion involving the rectum and anal canal. Biopsy of the lesion revealed invasive carcinoma with 2 distinct morphologies, a poorly differentiated small cell component and a minor adenocarcinoma component. We discuss the differential diagnosis of small cell carcinoma that includes mixed adenoneuroendocrine carcinomas and other neuroendocrine neoplasms. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Case Reports Source Type: research
Incidental Collision Tumor: Two Common Metastases Meet in the Neck
We present a case of intranodal collision between HPV-positive oropharyngeal squamous cell carcinoma and incidental papillary thyroid carcinoma. These two common lesions of the head and neck highlight an emergent area of complicated histology and raise interesting questions about tumor biology. We briefly review the variations of composite lesions described in the head and neck, as well as the potential prognostic implications between different types and role of ancillary testing and molecular diagnostics in their separation. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Case Reports Source Type: research
RET/PTC1 Rearrangement in Hashimoto Thyroiditis: Canonical WNT Expression Up-regulation for Neoplastic Promotion
Conclusions
The expression of RET/PTC1 highlights the link between inflammatory processes such as HT and neoplastic conditions such as HTA and PTC. The limited expression of TCF4, AKT, ERK1, and β-catenin supports the notion that the canonical WNT/β-catenin pathway plays a pivotal role in the development of this neoplasm. It is important to note that at this time, gene expression alone is not sufficient to make a distinction between benign and malignant thyroid lesions. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Case Reports Source Type: research
Role of Dynamic Markers in the Molecular Testing of Indeterminate Thyroid Nodules
Molecular testing of fine-needle aspirates of indeterminate thyroid nodules is now standard and consists mainly of mutational analysis of the most frequent point mutations and chromosomal rearrangements occurring in advanced thyroid tumors with the goal of determining these genetic alterations early in the neoplastic process. However, mutation panels, even extended ones, face challenges; namely, genetic alterations in cytologically indeterminate categories are represented at relatively low percentage, and with the exception of strong driver mutations, the mere presence of a mutation does not reliably predict malignancy.
C...
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Reviews Source Type: research
Cytology Slides for Molecular Analysis Can Address Both Interobserver Variability and Sample Heterogeneity: Overview of Thyroid Molecular Testing
Studies have shown that a high degree of inter and intraobserver variability, in addition to the heterogeneity of the sample itself, can inhibit the accuracy of cytopathological assessment of thyroid nodules. Guidelines have recommended the use of molecular analysis, used in conjunction with cytology, to assist in the guidance of patient management. Currently, there are several commercially available molecular tests offered to better assess overall malignancy risk, each now with updated and expanded capability. The collaboration between molecular pathology and cytopathology is critical to better understand the biology of t...
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Reviews Source Type: research
Editorial
No abstract available (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - January 1, 2019 Category: Pathology Tags: Editorial Source Type: research
Poorly Differentiated/Anaplastic Chordoma in a Child—Case Report and Review of the Literature
We present the case of a 3-year-old girl with a 5.0-cm sacrococcygeal mass. Magnetic resonance imaging showed a lobulated, heterogeneous mass attached to S5. Chordomas are very rare at this age; therefore, it is very important to distinguish this tumor from other more common neoplasms that occur in this location and age range because when they are identified their immunogenetic profile may suggest a worse prognosis. Histological, immunohistochemical, molecular characteristics, and differential diagnosis of this variant of chordoma are discussed. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - November 1, 2018 Category: Pathology Tags: Call for Papers 2017 Source Type: research
Phosphaturic Mesenchymal Tumor: A Single Case Report Discussing Diagnostic and Therapeutic Challenges of Tumor-Induced Osteomalacia
This report highlights the need for multidisciplinary diagnostic effort, effectiveness, of early surgical intervention, and emphasizes the importance of including this rare but damaging disease process in the differential diagnosis of osteomalacia. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - November 1, 2018 Category: Pathology Tags: Call for Papers 2017 Source Type: research
A Case Report of Pediatric Clear Cell Carcinoma of the Urinary Bladder Associated With Polyomavirus
We describe a urinary bladder tumor in an 8-year-old girl, which demonstrated similar features to clear cell carcinoma of the female genital tract with additional strong expression of SV40 large T antigen by immunohistochemistry. The patient had a history of severe infantile Crohn’s disease refractory to medical therapy, necessitating eventual stem cell transplant, complicated by graft-versus-host disease. Subsequent magnetic resonance enterography showed an incidental mass arising from the bladder dome, for which a partial cystectomy was performed. Histologically, the tumor demonstrated high-grade cytologic features wit...
Source: Pathology Case Reviews - November 1, 2018 Category: Pathology Tags: Case Review Source Type: research
Primary Renal Well-differentiated Neuroendocrine Tumor—Report of a Case With Cytological-Histopathologic Correlation and Review of Literature
Renal well-differentiated neuroendocrine tumor (WDNET; also known as carcinoid), although considered as a distinct entity in the World Health Organization classification, continues to be an enigma to the pathologists and clinicians because of its rarity. In this case report, we describe a case of primary renal WDNET in a 54-year-old man. The tumor was initially diagnosed as a urothelial carcinoma. After a second review and a broad-spectrum immunopanel, a revised diagnosis of WDNET was rendered. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - November 1, 2018 Category: Pathology Tags: Case Report Source Type: research
Renal Cell Carcinoma With (Angio)Leiomyomatous Stroma in a Patient With TSC2 Mutation: A Case Report
This report describes a unique presentation of a rare entity and brings attention to an evolving diagnostic field. We discuss problems and controversy surrounding the diagnosis of renal cell carcinoma with (angio)leiomyomatous stroma, its relationship to clear cell papillary renal cell carcinoma and other tumors, and how it correlates with newly discovered genetic mutations. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - November 1, 2018 Category: Pathology Tags: Call for Papers 2017 Source Type: research
